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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Intestinal Immunity"”.
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Study of intestinal immunity against Vibrio cholerae
xiii, 161, xxxiii leaves : ill., tables ; 26 cm
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THE ROLE OF GUT METABOLITES ON REGULATION OF INTESTINAL IMMUNITY
The gastrointestinal tract contains multiple types of immune cells that induce various immune responses to dietary antigens, commensal bacteria, and pathogens. Maintaining homeostasis at this mucosal barrier requires stringent regulation of the immune responses, including mechanisms to convey …
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Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23
… our laboratory has demonstrated increased intestinal tissue damage, leakiness and bacterial translocation as well as intestinal T lymphocyte suppression following EtOH intoxication and burn injury.</p> <p>Th17 cells are implicated in gut homeostasis and in the containment of gut pathogens. …
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Epithelial Retinoic Acid Receptor Beta Regulates Serum Amyloid A Expression and Vitamin A-Dependent Intestinal Immunity
… that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here I …
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Interactions Between Gut Microbial Composition, Mucosal Immunity and Metabolism
While evidence that the intestinal microbiome contributes to host health and disease has rapidly developed, the causal mechanisms that link these microbes to disease are largely elusive. The goal of this project was to explore the complex crosstalk between the microbiome and the immune system using …
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The Complex Interactions between Genetics and Environment: Diet, Inflammation and Intestinal Tumorigenesis
… fatty acids. Using the ApcMin/+ model of intestinal neoplasia and diets constructed from 58% coconut, corn or olive oils, we demonstrate that high amounts of dietary fats can have differential effects on DIO and MetS, as well as on intestinal tumorigenesis when compared to ApcMin/+ fed …
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Limiting host-microbiota interactions to control intestinal inflammation
The host intestinal tract lives in constant balance with the commensal microbiota residing in the intestinal lumen and immune responses must be tightly controlled. A strong intestinal barrier separates the immune system from resident microflora, and multiple mechanisms exist to reinforce the …
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… are reported to beneficially affect the host intestinal immunity. However so far, the biological pathways modulated by these nutrients in intestinal inflammation at the level of intestinal epithelial layer (IEL) remains elusive. To bridge this knowledge gap, the aim of our present study was …
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Investigation of mechanisms underpinning host-microbial interactions in the gastrointestinal tract
… in shaping the development and function of both intestinal and extra-intestinal immunity as reviewed in the introductory chapter (Chapter I) to this thesis. However in comparison to the vast numbers and diversity of bacteria that constitute the microbiota of a host, only the role of some of the …
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Human intestinal cells across space and time
Cells of the human intestinal tract undergo dynamic changes from development to adulthood and in response to environmental stimuli. Recent advances in high-throughput profiling of cells using transcriptomic approaches have vastly expanded the catalogue of cells that are found across the human body. …
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Intestinal CD4+T Cell Responses to Food
… polypeptides pass through the intestine. The intestinal immune system must maintain tolerance to these dietary antigens while still protecting against pathogens and noxious agents. Oral tolerance, a robust mechanism whereby oral administration of antigen results in both local and systemic …
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Molecular Mechanisms and Antigen Receptor Requirements for Lymphocyte Adaptation to Intestinal Tissues
… by just a single layer of epithelial cells. The intestinal immune system is thus tasked with being able to tolerate innocuous stimuli while mounting an effective response against potential pathogens in a controlled manner. To ensure appropriate balance between tolerance and resistance, T cells …
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The role of probiotics, prebiotics, and human milk oligosaccharides in infant formulae
… milk oligosaccharides have been shown to enhance intestinal maturation in vitro. Thus, we aimed to assess 1) the effects of the probiotic Bifidobacterium animalis subspecies lactis, 2) the prebiotics galacto- and fructo-oligosaccharides, and 3) the individual and combined effects of specific human …