Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Intestinal Homeostasis"”.
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Spatiotemporal dynamics of cell division in intestinal homeostasis
Intestinal homeostasis is governed by fate choices of stem cells residing in the intestinal crypt base. This must involve niche-specific co-ordination of cell division to guarantee that epithelial cells divide at the right time and place. These mechanisms operate to ensure precise control of the …
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Paneth Cell-Dependent Intestinal Homeostasis During T. Gondii Infection
The intestinal epithelial barrier faces the arduous task of constantly monitoring and controlling the diverse bacteria which colonize the gut. Key for this balance are the Paneth cells, highly specialized secretory epithelial cells in the intestinal crypts which secrete anti-microbial peptides to …
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Notch activation and clone fate in intestinal homeostasis and inflammation
… and functions depending on the tissue. In the intestinal epithelium Notch signals are important for determining cell fate between the absorptive and secretory lineage and regulating the proliferation of intestinal stem cells (ISCs). As a result, Notch is also an important pathway during disease …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… ligands and antigens from foods and microbiota. Intestinal homeostasis involves a balance between anti-inflammatory and pro-inflammatory signals. Intestinal epithelial barrier, commensal bacteria, and immune cells, along with the interactions between the three players maintain a toleranic …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… ligands and antigens from foods and microbiota. Intestinal homeostasis involves a balance between anti-inflammatory and pro-inflammatory signals. Intestinal epithelial barrier, commensal bacteria, and immune cells, along with the interactions between the three players maintain a toleranic …
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The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis
A key function of the gastrointestinal tract is to break down ingested food and absorb the contained nutrients and water. Within the intestinal tract are a number of specialised epithelial cells that aid in this process as well as maintaining immune homeostasis through their functioning as a …
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A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
… membrane of enterocytes and functions in the intestinal epithelium to protect against colitis. SMCR8, along with C9ORF72 and WDR41, is a member of a tripartite complex that functions as a guanine exchange factor. SMCR8 localizes to the lysosome, and its absence results in perturbations to …
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Novel effects of Prefoldin Pathway on Intestinal Homeostasis via Dietary Restriction in Drosophila melanogaster
… maintenance of the intestines of the organism. Homeostasis of the intestines is controlled by the regulation of intestine cell apoptosis and intestine cell proliferation. My research explores the role of two protein subunits found in a complex which may have possible functions in the regulation …
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Rac1 and IRE1 are Required to Prevent Early Loss of Intestinal Homeostasis in Drosophila melanogaster
<p>No abstract available</p>
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EPIGENETIC MECHANISMS OF POLYCOMB REPRESSIVE COMPLEX 1 IN INTESTINAL LINEAGE COMMITMENT
… development and cell identity maintenance during homeostasis (1). Polycomb group proteins primarily assemble into two different complexes: Polycomb repressive complex 2 (PRC2) with the catalytic subunit EZH1/2 which can mono, di, and tri- methylase the histone H3 at lysine 27 (H3K27); and Polycomb …
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Outlining a balance-point model of homeostasis in the small intestine of broiler chickens
… is to propose a novel model to understanding intestinal homeostasis in the face of various disturbance events. Chapter 2 investigated the effects of Runting Stunting Syndrome on broiler chickens in four different groups of chicks displaying clinical symptoms. The major finding in this study …
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Role of cytokine IL-15 in the homeostasis of the intestinal epithelium and inflammatory bowel diseases
… Crohn’s disease, are characterized by increased intestinal permeability caused by intestinal mucosal barrier dysfunction, a critical factor in the pathogenesis of IBD. The immune system is the major effector of this tissue damage, through the action of multiple cell types as well as soluble …
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Neutrophil Regulation of Colitis
The delicate intestinal homeostasis is regulated by interactions between microbiota, intestinal epithelial cells (IECs), and the intestinal immune system. As a crucial component of the innate immune system, neutrophils are the first responders to sites of inflammation when the intestinal epithelial …
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CROSSTALK BETWEEN PRC1 AND PRC2 IN INTESTINAL LINEAGE COMMITMENT AND CELL IDENTITY
… targeting distinct Polycomb activities in the intestinal epithelium, the present work proposes to characterize the interplay among the PRC1 subcomplexes and their relationship with PRC2 activity. In particular, it functionally dissects how PRC1 and PRC2 cooperate or have independent roles to …
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The role of mucus in the cross talk between gut bacteria and the host
Abstract The mammalian gastrointestinal tract is home to a complex microbial community engaged in a dynamic interaction with the immune system. Mucus is the first point of contact of the microbiota with the host, acting as a first line of defence. Furthermore γδ intraepithelial lymphocytes (IELs) …
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Activation and Maintenance of Intestinal Intraepithelial Lymphocytes (IELs)
The intestinal tissue is charged with a delicate immunological task. The intestinal immune system needs to be tolerant towards nutrients and microbiota present in the intestinal lumen, while simultaneously detecting and responding to dangers such as pathogens. A single-cell layer of intestinal …
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Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
… of bile acids have been shown to promote intestinal tumorigenesis in rodent models. Since high fat diet is considered a major risk factor for colorectal cancer (CRC), and is associated with increased bile acid concentrations in the colon, it has been proposed that bile acids contribute to …
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Development of Novel Methods to Study Host-Microbe Interactions In The Larval Zebrafish Gastrointestinal Tract
… pose significant challenges to the study of intestinal physiology and pathology. Zebrafish larvae, possessing optical transparency and genetic tractability, offer an accessible and clinically relevant model for investigating dynamic events in the intestine via time-lapse imaging. In the first …
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Intestinal Inflammation Model Inducing Gut Leakage by Different Methods in Broiler Chickens Using FITC-d as a Marker
… to reduce enteric inflammation and maintain intestinal homeostasis, thus improving performance. Due to increasing restrictions regarding the use of AGP, precise and high throughput enteric inflammation models and markers to search for effective alternatives are urgently needed. Oral …
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INKT CELLS CONTRIBUTE TO COLORECTAL CANCER PROGRESSION INDUCING NEUTROPHILS PRO-TUMORIGENIC FUNCTIONS
… immunity is involved in the patrolling of intestinal tissues and in the maintenance of homeostasis. Disruption of intestinal homeostasis leads to different pathologies, among which CRC. Invariant Natural Killer T (iNKT) cells are a lipid-specific, CD1d-restricted population of …
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