Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Intestinal Cancer"”.
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Intestinal cancer : linking infection, inflammation and neoplasia
Cancer is a leading cause of death in the world. Much work has been done to study the role of inflammation in carcinogenesis. One hypothesis suggests that inflammation causes oxidative stress that induces damage to cellular targets, including DNA. The multistep model of cancer proposes that cancer …
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Characterisation of the role of Fas in intestinal inflammation and cancer
… cross-talk between TLRs and Fas/FasL system in intestinal cancer cells. Results: Treatment with TLR4 and TLR5 ligands, but not ligands for TLR2 and TLR9 increased the expression of Fas and FasL in intestinal cancer cells in vitro. Consistent with this, expression of Fas and FasL was reduced in …
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Somatic mutagenesis in humans with deficient DNA repair
… in normal cells causes the development of cancer and is implicated as a potential mechanism in the physiological process of ageing. In recent years our ability to interrogate the genome of human cancers and the normal tissues from which they arise has expanded greatly. These studies have …
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Telomeric Regulation of Chromosomal Instability In Colorectal Cancer
… While CIN provides a mutator mechanism for cancer-relevant genomic events, its role in shaping tumor biology during carcinogenesis is not well understood. Here, we explored the molecular and biological impact of telomere dysfunction and associated CIN <em>in vivo</em> in a faithful model of …
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Elucidating the biology of G-protein coupled receptor 35
… (UC). GPR35 is also upregulated in numerous cancers. Multiple studies of GPR35 have so far fallen short of revealing its core biology. In this project we set out to gain further understanding of the biology of GPR35. Starting with unbiased protein interaction studies, we showed that GPR35 …
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Mucin expression in normal and diseased states of the stomach : a histochemical and immunohistochemical study
… chronic active gastritis, low grade dysplasia, intestinal metaplasia (associated with gastritis, benign ulcers, dysplasia and cancer), early and advanced intestinal type adenocarcinoma, and diffuse adenocarcinoma]. MUCJ-7 antibodies were used in the study, this being the first study to all …
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The Complex Interactions between Genetics and Environment: Diet, Inflammation and Intestinal Tumorigenesis
… contribute to the development and progression of cancer, especially colon cancer. DIO and MetS have reached epidemic proportions in the United States and are heavily influenced by diets high in saturated and omega-6 polyunsaturated fatty acids. Using the ApcMin/+ model of intestinal neoplasia and …
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Behavioral and genetic characteristics of intestinal cell lineages in health and disease
The intestinal crypt is a highly dynamic system, as the entire epithelium is constantly turned over and renewed by the proliferative stem cells located at the bottom of the crypt. While this system is crucial for nutrient absorption, any derangements in the proliferative cells can quickly lead to …
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Optimierung der prophylaktischen Wirkung von Phospholipiden auf die Adhäsion von freien Kolonkarzinomzellen
… carcinosis based for instance on colorectal cancer, is a serious diagnosis with very poor prognosis. Therapeutic options are limited, and even radical operations are mostly not curative but palliative by nature. Therefore, the goal in every treatment of a cancer in the peritoneal cavity …
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The origin and properties of pro-oncogenic fields in the intestinal epithelium
Abstract: The intestinal epithelium is maintained by intestinal stem cells that replace each other stochastically over time. Stem cells that are excluded from the stem cell pool will differentiate into the absorptive or secretory cell lineages. However, intestinal cell-fate specification is not …