Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Intervertebral Disc Degeneration"”.
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Development of translational models for intervertebral disc degeneration using a comparative approach for canine and human patients
Intervertebral discs (IVDs) are unique musculoskeletal tissues within functional spinal unit organs comprising the spinal column that distribute loads and allow complex movements for vertebrates. IVD degeneration has been closely associated with manifestations of symptomatic IVD disease (IVDD). …
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Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration
Intervertebral discs (IVDs) are the cartilaginous structures in the spine that connect adjacent vertebrae, absorb shock from daily activities, and allow for articulation of the spine. Unfortunately, IVDs are prone to degeneration and have little to no capacity for self-repair. IVD degeneration is …
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Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis
Intervertebral disc degeneration has been identified as a main cause for low back pain, a large health problem in the Western world today with 60%-80% of people affected at some point during their lives. Current treatments alleviate the symptoms rather than repair the tissue, but tissue engineering …
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Ο ρόλος της αναστολής της ιντερλευκίνης 1β (IL-1β) στην εκφυλιστική νόσο του μεσοσπονδύλιου δίσκου
Η εκφύλιση του μεσοσπονδύλιου δίσκου (Intervertebral Disc Degeneration - IDD) είναι μια ευρέως διαδεδομένη παθογόνος κατάσταση που επηρεάζει το 12% με 35% του πληθυσμού παγκοσμίως. Πληθώρα ερευνών έχουν αναδείξει ότι ο εκφυλισμός του μεσοσπονδύλιου δίσκου είναι απόρροια διαφόρων παραγόντων όπως η …
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MRI Assessments of Adjacent Disc Degeneration of Lumbar Fusion Group versus Discectomy Group
OBJECTIVE: Using MRI to assess intervertebral disc degeneration at adjacent levels in a group of patients who underwent spinal fusion compared to a group of patients who underwent discectomy. MATERIALS AND METHODS: Fifty-six patients who underwent spinal surgery for lumbar degenerative disease by …
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Numerical Techniques for the Noninvasive Assessment of Material Properties and Stresses in Soft Biomaterials
… of the body such as articular cartilage or the intervertebral disc. Such methods will allow for non-contact and patient-specific modeling in a manner not currently possible with traditional mechanical testing or finite element techniques. Therefore, the objective of this thesis was to develop …
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An in Vitro Microenvironment for Nucleus Pulposus Regeneration
Intervertebral disc degeneration begins early in life, increases with age, and can ultimately result in disc failure. At the center of the disc, the nucleus pulposus (NP) resides in a hypoxic environment where degeneration is thought to begin. Initially, nucleus pulposus cells (NPCs) display …
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In Vitro Assessment of Bone and Cartilage Stimulating Peptides
… one of the most commonly used surgeries to treat intervertebral disc degeneration (IDD) related low back pain. However, non-fusion still occurs in about 10-15% of the clinical cases. The global objective of this project is to develop a synthetic bone graft for the spinal fusion, combined with bone …
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Influence of mitochondrial and nuclear genomic dysfunction on lipid homeostasis in lipidemic diseases
Intervertebral disc degeneration (DDD) is a multifactorial, age-related disorder and a major contributor to chronic low back pain (LBP) and disability. Its pathogenesis involves extracellular matrix degradation and inflammation, augmented by mitochondrial dysfunction and dysregulated lipid …
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Extracellular Matrix Degradation and Mechanical Integrity of Degenerated Human Annulus Fibrosus from Surgical Specimens
Intervertebral disc (IVD) degeneration is a leading cause of low back pain, yet the mechanistic link between biochemical matrix degradation and functional mechanical failure of the annulus fibrosus (AF) remains poorly defined in human tissue. The interlamellar matrix (ILM), which binds adjacent …
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From Protein Structure to Clinical Strategy: An In silico Investigation of Mitochondrial DNA Mutations in Type 2 Diabetes and Degenerative Disc Disease for Targeted Nutritional Interventions
… Type 2 Diabetes Mellitus (T2DM) and Degenerative Disc Disease (DDD), represent major contributors to global morbidity and mortality, particularly within low- and middle-income countries where aging populations and chronic metabolic stress intersect. Increasing evidence identifies mitochondrial …
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Molecular studies of aggrecan : experiments and simulations
… (ECM) of the cartilaginous tissues such as human intervertebral disc, the large self-assembling proteoglycans, aggrecan, are essential for the disc in resisting multiaxial compressive loads. Aggrecan degradation, a combinational result of abnormal and/or reduced cellular synthesis and proteolytic …
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A Novel Role for HAPLN1 in Skeletal Development
Adolescent idiopathic scoliosis (AIS) is a potentially progressive spinal curvature that occurs during rapid growth and has a multi-factorial genetic etiology. Prior genetic studies in humans and animal models support differences in cartilage development in the pathogenesis of AIS. Here, we …
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Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc
… of extracellular gene expression in murine intervertebral disc (IVD) cells in response to mechanical load. We investigated the role of TRPV4 in age associated IVD degeneration and spine development using novel knockout mice. Spine samples were harvested from NotoCre;Trpv4fl/fl and WT mice at …