Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"Intervertebral Disc"”.
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The effect of position on the lumbar intervertebral disc.
… investigate the effect of position on the lumbar intervertebral disc (IVD). The effect of position on the lumbar IVD in asymptomatic subjects and subjects with discogenic low back pain (DLBP) was explored using positional Magnetic Resonance Imaging (pMRI). Convenience samples of 11 asymptomatic …
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Effects of high intensity focused ultrasound on the intervertebral disc
… intensity focused ultrasound treatment of the intervertebral disc. We demonstrated that it was possible to heat intervertebral discs with HIFU delivered by 50 or 5 mm diameter ultrasound transducers. Finite element studies indicated that it would be possible to heat the disc to a temperature of …
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The investigation of the structural behavior of the intervertebral disc
Thesis (M.S.) Massachusetts Institute of Technology. Dept. of Civil Engineering, 1956.
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Mechanisms for regenerative intervertebral disc healing during early growth in mice
<p>Annulus Fibrosus (AF) defects of intervertebral discs (IVDs) cause painful disability, for example when herniated tissue compresses against adjacent nerves. Discectomy, the current standard of treatment to address herniation, does not repair AF defects and can result in re-herniation and …
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Mechanics of biomimetic materials for tissue engineering of the intervertebral disc
… shift in the treatment of back pain. Engineered intervertebral discs could replace degenerated tissue and overcome the limitations of current treatments that disrupt the biomechanics of the spine. New materials, which exhibit sophisticated mechanical responses, are needed to provide templates for …
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A collagen-GAG matrix for the growth of intervertebral disc tissue
Intervertebral disc (IVD) degeneration and herniation is a significant problem, more so in the aviation field. The IVD also changes during spaceflight. Current treatments for IVD problems can have unfavorable long-term consequences. This thesis investigated a porous, biodegradable …
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Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc
… of extracellular gene expression in murine intervertebral disc (IVD) cells in response to mechanical load. We investigated the role of TRPV4 in age associated IVD degeneration and spine development using novel knockout mice. Spine samples were harvested from NotoCre;Trpv4fl/fl and WT mice at …
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Mechanical Properties Of The Intervertebral Disc As An Estimator Of Postmortem Interval
… it is proposed to use the degradation of the intervertebral disc (IVD) after death to determine a relationship between the mechanical properties of cadaveric tissue and time since death in order to extend the 60-hour window. To that end, 1 fresh human spine and 6 pig spines were each separated …
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Towards an Intelligent Intervertebral Disc Prosthesis for the Assessment of Spinal Loading
… problem when the causes are due degenerative disc diseases and damaged vertebrae. The main causes for degenerative disc are extremely complex and still not well understood, although in their majority are strongly related to the acute and frequent mechanical loading on the spine. Knowledge that …
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Magnetization Transfer and Diffusion Tensor Imaging in Dogs with Intervertebral Disc Herniation
… dogs with spinal cord injury (SCI) secondary to intervertebral disc herniation (IVDH). Hypothesis: Magnetization transfer ratio (MTR), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) will be significantly different in patients with a …
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Load bearing regenerative repairs for the cartilaginous soft tissue of the intervertebral disc
… soft tissues such as the nucleus pulposus in the intervertebral disc are affected by degenerative diseases and physical injury, which if not treated early can initiate a progressive decline in joint function and result in lower back pain. Early treatment options to repair the nucleus pulposus, …
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Experimental and finite element analysis of mechano-electrochemical effects in intervertebral disc biomechanics
… 80% of the population and has been attributed to intervertebral disc injury as well as the degenerative adaptations which occur with advancing age. Much of our understanding of disc mechanics comes from mathematical and finite element models; however, there is a lack of empirical data which is …
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The regional susceptibility of the intervertebral disc to mechanically induced disruption and herniation
Internal disc disruption and herniation are associated with low back pain and while it is widely accepted that the posterior and posterolateral regions of the disc are the primary herniation sites, much less is known about mechanisms of herniation operating in other regions of the disc. The aim of …
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In vivo lumbar spine biomechanics : vertebral kinematics, intervertebral disc deformation, and disc loads
… to calculate the physiological loads on the intervertebral disc. The system was shown to be accurate and repeatable in determining the vertebral kinematics in all degrees of freedom. For the first time, six degree-of-freedom motion of different structures of the spine, such as the vertebral …
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Development of an ultrasound system to measure in vivo dynamic cervical spine intervertebral disc mechanics
… equipment with most problems attributed to intervertebral disc complications. Currently, CT and MRI are the gold standards for the evaluation ofthe cervical spine. However, those modalities are not suited to capture real-time biomechanical information in extreme environments. Clinical …
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Minimally Invasive, Integrated Endoscopic Hemilaminectomy for Hansen Type I Intervertebral Disc Extrusion in Chondrodystrophic Dogs
… dogs with clinically relevant Hansen type 1 intervertebral disc extrusion (IVDE). Study subjects included five client-owned chondrodystrophic dogs under 15kg with an acute, single site IVDE between T10 and L5 of less than 90 days duration and no loss of deep pain perception. The extent of the …
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Development of translational models for intervertebral disc degeneration using a comparative approach for canine and human patients
Intervertebral discs (IVDs) are unique musculoskeletal tissues within functional spinal unit organs comprising the spinal column that distribute loads and allow complex movements for vertebrates. IVD degeneration has been closely associated with manifestations of symptomatic IVD disease (IVDD). …
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Cadherin-Mediated Cell-Cell Interactions Regulates Phenotype And Morphology of Nucleus Pulposus Cells Of The Intervertebral Disc
<p>Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with numerous cell-cell interactions. With maturation and aging, NP cells lose their ability to form these cell clusters, with associated changes in NP cell phenotype, …
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Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration
Intervertebral discs (IVDs) are the cartilaginous structures in the spine that connect adjacent vertebrae, absorb shock from daily activities, and allow for articulation of the spine. Unfortunately, IVDs are prone to degeneration and have little to no capacity for self-repair. IVD degeneration is …
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An Investigation Into The Mineral And Mechanical Properties Of The Canine Intervertebral Disc And Its Clinical Implications
Intervertebral disc disease is a very common problem in dogs. The disease causes pain and different degrees of neurological damage which can result in paralysis and leads to the death of many dogs annually. The disease is intimately associated with disc degeneration and calcification, but the …
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