Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Interstrand crosslink"”.
-
Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
<p>DNA interstrand crosslink (ICL) repair is vital for cellular proliferation and survival. Defects in the repair of DNA crosslinks have been associated with congenital abnormalities, bone marrow and kidney failure, liver dysfunction, and cancer. DNA nucleases play a significant role during the …
-
The Fanconi anemia pathway and HELQ work alongside dormant replication origins to suppress replication-associated genome instability
… displayed modest FA-like phenotypes such as interstrand crosslink hypersensitivity and hypogonadism, but not defects in homologous recombination repair. Rather, HELQ was found to work in parallel to the FA protein FANCC to suppress replication-associated genome instability.
-
Fancm and Faap24 Maintain Genomic Stability Through Cooperative and Unique Functions
… from FA patients is hypersensitivity to DNA interstrand crosslinking agents such as mitomycin C (MMC) and cisplatin, suggesting that FA- and FA-associated proteins play important roles in protecting cells from DNA interstrand crosslink (ICL) damage. Two genes involved in the FA pathway, FANCM …
-
High-resolution NMR spectroscopic analysis of anticancer drugs, DNA and their interactions: 1. Platinum anticancer compounds - DNA interactions. 2. Anthracycline drugs - DNA interactions and modified DNA
… The structure of an intrastrand cisplatin-crosslinked didentate DNA duplex consisting of d(CCTG$\rm\sp*G\sp*$TCC) and its complement d(GGACCAGG) is determined by NMR spectroscopy. The refined duplex is unwound ($\sim{-}21\sp\circ$) and kinked (${\sim}58\sp\circ$) toward the major groove at …
-
Investigation into ubiquitin signalling in response to cisplatin
… drug that acts by introducing toxic DNA interstrand crosslinks into proliferating cells, causing both cytostatic and cytotoxic effects. Although various models of the interstrand crosslink (ICL) response have been proposed, none of them are complete and much still remains unknown about …
-
Modulated Functions of The Fanconi Anemia Core Complex
… are characterized by hypersensitivity to DNA interstrand crosslinks (ICLs), suggesting that FA genes play a role in ICL repair. Fanconi anemia core complex (including A, B, C, E, F, G, L, FAAP20, and FAAP100) activates the Fanconi pathway by providing the essential E3 ligase activity for …
-
Nucleotide Excision Repair, Crosslink Repair and Transcriptional Function of Xpa In Human Cells
… enhances sensitivity of mammalian cells to DNA interstrand crosslinks (ICL)-generating agents. I found that XPA is retained on damaged DNA following exposure to UVA-activated psoralen, and investigated repair of a triplex forming oligonucleotide (TFO)-directed psoralen ICL. A TFO-directed …
-
New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… two major threats to genomic stability: DNA interstrand crosslinks (ICLs), and the expansion of trinucleotide repeats. ICLs are highly deleterious lesions that disrupt replication, are destructive to dividing cells, and are extremely toxic to the hematopoietic system. The …