Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Interstrand Cross-link"”.
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Structural and Functional Characterization of Human SNM1A
<p>DNA interstrand cross-links (ICLs) occur when various chemical agents bind to chromosomal DNA and form a covalent bond between adjacent strands, preventing unwinding of the DNA double helix. The formation of an ICL is therefore extremely toxic to cells and necessitates quick removal and …
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The responses of cellular proteins to cisplatin-damaged DNA
… by proteins that bind to the cisplatin-DNA cross-links or influence cellular pathways in response to the genotoxic stress. In either case, such factors can regulate the processing of the cisplatin lesions and thereby affect cellular sensitivity to the drug. Identification of these proteins …