Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Interstitial lung disease"”.
-
The Role of Silicates in Interstitial Lung Disease
Interstitial Lung disease (ILD), produces disruption of alveolar walls with loss of functionality and accumulation of scar tissue. Asbestosis and silicosis are the ILD produced by the inhalation of asbestos fibers or silica particles respectively. An increase in prostacyclin release after exposing …
-
The Role of Silicates in Interstitial Lung Disease
Interstitial Lung disease (ILD), produces disruption of alveolar walls with loss of functionality and accumulation of scar tissue. Asbestosis and silicosis are the ILD produced by the inhalation of asbestos fibers or silica particles respectively. An increase in prostacyclin release after exposing …
-
Prognostication and disease monitoring in fibrotic interstitial lung disease
Introduction Fibrotic interstitial lung disease (f-ILD) causes significant morbidity and mortality worldwide. Progressive pulmonary fibrosis (PPF) describes a cohort of patients who develop progressive disease despite standard treatment. To provide optimal care, it is vital to identify those …
-
Interstitial lung disease (ILD) in adult patients with autoimmune connective tissue disease (CTD) at Groote Schuur Hospital
Introduction. Interstitial lung disease (ILD) is prevalent in patients with autoimmune rheumatic diseases (ARD), leads to significant morbidity and mortality and is poorly characterized in South Africa (SA). We undertook this study to describe the clinical, serological and radiological features of …
-
The experience of palliative care service provision for people with non-malignant respiratory disease: an all-Ireland qualitative study
… for people with advanced non- malignant lung disease. Yet there is limited evidence regarding the integration of palliative care for people with interstitial lung disease, bronchiectasis and COPD. This study aimed to explore the experience of palliative care provision for people with …
-
LUNG PATTERN CLASSIFICATION VIA DCNN
<p>Interstitial lung disease (ILD) causes pulmonary fibrosis. The correct classification of ILD plays a crucial role in the diagnosis and treatment process. In this research work, we disclose a lung nodules recognition method based on a deep convolutional neural network (DCNN) and global features, …
-
Deep Learning Based Approaches For Low Cost Defense Detection
<p>Pulmonary fibrosis is a progressive interstitial lung disease characterized by the accumulation of fibrotic tissue within the lungs, leading to impaired respiratory function and reduced quality of life. Early detection is important for disease management; however, accurate diagnosis often relies …
-
Clinical evaluation of fibrotic idiopathic interstitial pneumonia
… history to exclude identifiable causes of interstitial lung disease is required. Although the median survival is poor, there is considerable variability in disease progression. This thesis investigates the diagnostic accuracy of IPF, a novel treatment option for IPF and biomarkers …
-
Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease
Chronic lung diseases are often complicated with pulmonary hypertension (PH). This can lead to disability and poor prognosis. Oxidative stress has been implicated in the development of PH and right ventricular hypertrophy (RVH).A possible new way to treat lung disease related pulmonary hypertension …
-
Regulation of Endothelial Nitric Oxide Synthase in Pulmonary Myofibroblasts
<p>Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease leading to decreased lung volume and eventual respiratory failure. At present, the median post-diagnosis lifespan is between three and six years. Myofibroblasts are collagen-secreting cells essential for wound healing, but also …
-
Investigating pulmonary vascular B cells
The lung is a vital organ which is required for gas exchange. The anatomy of the lung itself, immune molecules, and leukocytes provide the host with protection from harmful debris and pathogenic stimuli. A component of pulmonary host defense is neutrophils which are found within the lung capillary …
-
Structural and functional pulmonary imaging using hyperpolzarized xenon-129
… tissue allow probing important properties of the lungs. Three methods that study structure and function of the lungs, Chemical Shift Saturation Recovery (CSSR), Xenon polarization Transfer Contrast (XTC) and Dixon, and their application to human studies for the first time are the focus of this …
-
Role of type I interferon in pulmonary inflammation and fibrosis
… fibrosis is a severe and potentially fatal lung disorder characterized by progressive respiratory dysfunction, imposing significant burdens on both society and affected families. This condition frequently occurs secondary to other diseases, particularly autoimmune disorders, where the …
-
HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
<p>Hypersensitivity Pneumonitis (HP) is an interstitial lung disease caused by repeated inhalation of a wide range of environmental antigens. It is characterized by alveolitis, granuloma formation, and fibrosis. Since HP is a T cell-mediated disease, it is important to determine the type of T cell …
-
The pathogenesis of idiopathic pulmonary fibrosis
… disorder of unknown aetiology with a relentless disease course and a median survival of 3 years after the diagnosis. It is the most common idiopathic interstitial lung disease (ILD) with a basal and peripheral predominance associated with temporal and geographical heterogeneity. As the …
-
A retrospective study of patients with biologics treatment at Groote Schuur and Red Cross Children's War Memorial Hospitals
… infections, limit the use of biologic disease-modifying anti-rheumatic (bDMARD) therapies. We undertook this retrospective study to document their use for immune-mediated diseases (IMDs) and explore the efficacy, safety, adherence and screening practices prior to initiating bDMARDs in a …
-
Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… pneumonitis (HP) is an inflammation driven interstitial lung disease characterized by inflammation of the interstitium, bronchioles, and alveoli of the lung that leads to granuloma formation. Myeloid lineage immune cells play a critical role in the early and late stages of the disease, and …
-
Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
<p>Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by repeated inhalation of environmental antigens. The disease is characterized by alveolitis and granuloma formation; however, some patients develop chronic HP (CHP), a restrictive lung disease characterized by fibrosis. …
-
Dynamic 129Xe Magnetic Resonance Spectroscopy: Development and Application in Diverse Cardiopulmonary Diseases
<p>Chronic respiratory diseases are one of the leading causes of death in the US and a driving factor in their mortality rate is the presence of comorbid cardiovascular diseases such as pulmonary hypertension (PH). As an increasing number of patients exhibit concomitant cardiac and pulmonary …
-
To evaluate the role of miRNAs as potential diagnostic and prognostic biomarkers for Asbestos-related interstitial lung diseases (ILD), Non-Small Cell Lung Cancer (NSCLC) and Malignant Pleural Mesothelioma (MPM)
… cancer mortality worldwide. Asbestos-related lung cancer (LC) and malignant pleural mesothelioma (MPM) prognosis is still poor especially at advanced stage, which highlights the need for early diagnosis and effective biomarkers capable of detecting these diseases at early, potentially …
Page 1 of 2