Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Interstitial fluid pressure"”.
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Effects of Combined Bevacizumab and Paclitaxel On Tumor Interstitial Fluid Pressure In A Preclinical Breast Cancer Model
… of Combined Bevacizumab and Paclitaxel on Tumor Interstitial Fluid Pressure in a Preclinical Breast Cancer Model by Ricardo H. Alvarez Several mechanisms of cell resistance are often accountable for unsuccessful chemotherapy against cancer. Another reason, which has received increased attention, …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… the vascular permeability to macromolecules and interstitial fluid pressure are reduced. By lowering interstitial fluid pressure while maintaining microvascular pressure, DC101 induces a hydrostatic pressure gradient across the vascular wall, which leads to enhanced penetration of macromolecules …
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A TISSUE ENGINEERING APPROACH TO THE DEVELOPMENT OF AN IN VITRO 3D TUMOR MODEL FOR DRUG DELIVERY STUDIES
… were cultured in a bioreactor with replicated interstitial fluid pressure, and these constructs were found to closely approximate the subcutaneous tumors in SCID mice.
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Functions of small leucine-rich repeat proteoglycans in connective tissues
… is abundant in cancer stroma, raising its interstitial fluid pressure that hinders an efficient anti-cancer drug medication. Furthermore, fibromodulin is expressed in atherosclerotic plaques, regulating the growth of the fibrous cap and activity of smooth muscle cells. These observations …
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Analysis of anti-cancer drug penetration through multicell layers in vitro. The development and evaluation of an in vitro model for assessing the impact of convective fluid flow on drug penetration through avascular cancer tissues.
High interstitial fluid pressure (IFP) in tumours is recognized as a barrier to drug delivery resulting in reduced efficacy. High IFP impedes the normal process of convective fluid flow (CFF) from blood vessels into the interstitium. The aim of this study was to develop an in vitro model that could …
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Thermotherapeutic enhancement of infusate distribution during convection enhanced delivery in the brain using fiber-optic microneedle devices
… temperature groups. 42°C brains demonstrated interstitial and intracellular distribution, while rare intracellular distribution was noted in the other groups. Discussion: The Vd of FMD-CED infusions is facilitated by sub-lethal thermotherapy. This study indicates that thermotherapeutic …
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Extracellular Fluid Systems in the Brain and the Pathogenesis of Hydrocephalus
… related to the locations of Cerebrospinal Spinal Fluid (CSF) absorption deficit and causes of the pressure gradients that expand the ventricles with hydrocephalus remain largely unanswered. Work in the Johnston lab over a 15 year period has demonstrated that CSF moves through the cribriform plate …
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Mechanotransduction of interstitial fluid stresses and effects on tumor cell migration
… cancer more treatable. Osmotic and hydrostatic pressure gradients within the extracellular matrix (ECM) drive flow of interstitial fluid through the ECM. Elevated osmotic pressure, lymphatic collapse, solid stress, and increased microvascular permeability contribute to elevated interstitial …
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Shear Stress-Mediated Tumor-Endothelial Cross Talk Regulates the Angiogenic Potential of Breast Tumors In Vitro
… tumor vasculature generate regions of elevated interstitial fluid pressure and aberrant flow shear stress within the tumor microenvironment. While research has shown that the hydrodynamics of the tumor vasculature reduce transport and uptake of therapeutic agents, the underlying mechanisms by …
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Pancreatic Cancer: Oncomicrobes, Electric Fields, and Fluid Flow
… progression and how stromal elements impact interstitial fluid dynamics. This dissertation examines dual aspects of this complexity: first, by elucidating the specific contributions of Fusobacterium nucleatum (F. nucleatum) to pancreatic cancer pathogenesis and developing a novel therapeutic …
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Using Mechanical Interventions To Enhance Drug Transport To Bone Tumors
… in the tumor microenvironment and elevated interstitial fluid pressure, tissue penetration of therapeutic agents is often more limited in cancerous tumors compared to normal tissue. Weight-bearing mechanical loading applied to bone, as well as other mechanical stimulations such as vibration, …