Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Interstitial cells of Cajal (ICC)"”.
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NOVEL APPROACHES TO TESTING GASTRO INTESTINAL FUNCTION IN VITRO: CONTROLLING SIGNAL ACQUISITION, TISSUE COMPOSITION, OR THE PLATFORM
… includes smooth muscle, enteric neurons, and interstitial cells of Cajal (ICC). Depletions of these cell populations are associated with several motility disorders, and their significant effects on function are uncertain. In this thesis, several different approaches are studied to understand …
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Spatio-Temporal Calcium Dynamics of the Interstitial Cells of Cajal
The Interstitial Cells of Cajal (ICC) are responsible for producing pacemaking signals that stimulate rhythmic contractions in the gastro-intestinal system. The pacemaking signals are generated by membrane depolarizations, which are in turn linked to the integrated transport of calcium between the …
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Inter-organ Communication in the Gut: Elucidating Electromechanical Coupling across the Gastroduodenal Junction
Electromechanical coupling of the gastroduodenal junction (GDJ) has been indicated as a target for clinical management of disorders of gut-brain interaction (DGBI) and dysmotililty conditions. Rhythmic ‘slow waves’, generated by interstitial cells of Cajal (ICC), and myogenic ‘spikes’ are …
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A Fundamental Investigation into the Presence of Interstitial Cells of Cajal within the Gastrointestinal Tract of Dania rerio
… results from the complex interactions between interstitial cells of Cajal (ICC), enteric neurons, and smooth muscle cells. Kit positive immunoreactivity has been extensively utilized as a marker for ICC; these cells function to generate rhythmic depolarization in the GI smooth muscle termed the …
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Targeted ablation therapy for treatment of gastrointestinal dysrhythmias
Bioelectrical slow waves are one of the main coordination mechanisms of gastric motility. Slow wave dysrhythmias occur in gastric motility disorders, offering a potential therapeutic target. This thesis aimed to investigate the feasibility and safety of using radio-frequency (RF) ablation to …
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Keeping Pace with Interstitial Cells of Cajal: Modelling Gastrointestinal Electrophysiology
… control systems. This thesis focuses on one of these mechanisms: an intrinsic bioelectrical activity called slow waves, which originates in pacemaker cells called interstitial cells of Cajal (ICC) located within the smooth muscle layers of the GI tract. The mechanism by which ICC generate …
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High performance computational simulations of gastrointestinal electrical activity
… essential for physical propulsion and digestion of food, is coordinated by an underlying electrical activity called slow waves (SWs). SWs are initiated and propagated by specialised cells called interstitial cells of Cajal (ICC) supplying the smooth muscle cells (SMC) with the necessary stimulus …
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Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… (1) characterizing the basal expression level of Ca2+ sensitization proteins in unstimulated gastrointestinal (GI) smooth muscles from regionally and functionally distinct regions and (2) addressing a fundamental question in the smooth muscle field; does exogenously applied agonist in the …