Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 974 for “"Interrogate"”.
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Methods to interrogate cells and their interactions with single-cell resolution
Only recently have molecular methods achieved high-quality and unbiased representations of diverse intracellular molecules at the single-cell level. With this technological advancement, researchers have begun deconvolving population-level measurements to understand whether prior observations were …
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Machine Learning to Interrogate High-throughput Genomic Data: Theory and Applications
The missing heritability in genome-wide association studies (GWAS) is an intriguing open scientific problem which has attracted great recent interest. The interaction effects among risk factors, both genetic and environmental, are hypothesized to be one of the main missing heritability sources. …
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"Sometimes You'Ll Feel Like An Outcast": Using Superman To Interrogate The Closet
Over the years, an increasing number of scholars have argued that a "coming out imperative" characterizes Western society, urging those who harbor hidden identities to make those identities visible for the greater good. A number of sources repeatedly remind queer-identified individuals, for …
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Development of microfluidic devices to maintain and interrogate tissue biopsies - biomedical applications
Currently most cell-based methodologies in microfluidic systems utilize homogeneous or heterogeneous cell populations. However, these systems do not present an accurate representation of in vivo dynamics. A microfluidic based experimental methodology has been developed that offers a biomimetic …
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Crafting counter-hegemony: using porcelain to interrogate ideological whiteness as anti-racist praxis
I use porcelain to ponder, problematise and pervert ideological whiteness. This interdisciplinary, practice-based PhD responds to the colonial legacy and ongoing crisis of white supremacy. It asks whether porcelain – so physically white and so historically and symbolically laden with preciousness, …
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Chemical Biology Approaches to Interrogate Heat Shock Transcription Factor 1 Regulation in Cancer
<p>Heat Shock transcription Factor 1 (HSF1) has long been recognized as the master regulator and signal integrator in the eukaryotic proteotoxic stress response. Revealed by recent discoveries in cancer, the functions of HSF1 have extended far beyond its canonical role in protein folding, further …
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Use of Genetically Encoded Tools to Interrogate Mechanisms of Glutathione Homeostasis from Mitochondria to Mice
<p>Glutathione is an evolutionarily ancient molecule that underlies many critical biological processes across all categories of life. It acts as a cofactor in some metabolic reactions, modifies proteins to modulate their activity, and participates in detoxification of xenobiotic compounds. Despite …
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Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase
Protein-protein interactions (PPIs) are prevalent in Nature and so are attractive targets for chemical biology and drug discovery. Modulating PPIs is challenging because of the nature of their interacting surfaces. Nevertheless, recent progress has led to the discovery of small molecule modulators …
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The Development and Characterisation of a Peptide Delivery Platform to Interrogate the Anticancer Effects of Bisphosphonates
The RALA peptide delivery system complexes anionic compounds through electrostatic interactions, to form a nanoparticle with the physiochemical characteristics to cross cellular membranes and escape endosomes; thereby releasing the cargo intracellularly to exert the optimal therapeutic effect. …
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A 3D synthetic extracellular matrix that can be dissolved to interrogate the cellular local microenvironment on demand
… system that can be locally and accurately interrogated. We begin by investigating the underlying principles directing morphogenesis in 3D synthetic PEG hydrogel cultures by screening the relevant parameter space - specifically, the intertwined relationship between adhesion and matrix …
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Application of NMR spectroscopy to interrogate the structures of bacterial protein toxin membrane localization domains and amphotericin B
Infectious disease is a significant health concern. The transmissible nature of these diseases as well as developing issues such as antimicrobial resistances provide a unique challenge to public health and can have significant and potentially unpredictable impacts to the world economy. Combatting …
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A Practice-as-Research Project utilizing Butler’s (1990) Feminist/ Post-structuralist theory of Gender Performativity, as well as Connells (2001) system of Hegemony, Complicity, and Subordination to Interrogate the Formation of Toxic Masculinities through Practice-as-Research and Live Art Methodologies
In the past twenty years or so, the concept of masculinity has come under increasing scrutiny. What used to constitute as socially acceptable behaviour for men to engage in, has increasingly become challenged by developments such as the MeToo movement. There are now stable grounds to argue that …
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Re-visioning Katrina: Exploring Gender in pre- and post-Katrina New Orleans
… Katrina, and the storm's aftermath, one must interrogate the cultural conflation of the black female body and the city's legacy to explore what it means and how it situates real black women in social, cultural, and physical landscapes. Using a hybrid theoretical framework informed by Black …
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Interrogation of fibre optic sensors
… of amplified electrical outputs. It is used to interrogate fibre Bragg grating and interferometric sensors. Using the properties of polarisation maintainability in high-birefringent fibre an interrogating interferometer was realised by winding a length of the fibre around a piezoelectric …
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PARSES: A Pipeline for Analysis of RNA-Sequencing Exogenous Sequences
… become one of the most widely used techniques to interrogate the transcriptome of an organism since the advent of next generation sequencing technologies [1]. A plethora of tools have been developed to analyze and visualize the transcriptome data from RNA-Seq experiments, solving the problem of …
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Multiplexed genotyping of single nucleotide polymorphisms using microarray technology
… to adapt minisequencing to solid support to interrogate multiple SNPs which had been reported to be associated with coronary artery disease. This microarray-based platform has demonstrated a great potential for highly parallel genotyping. Secondly, an innovative two-color platform (TATLIPEXA) …
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Politics and prosthesis : representing disability in South Africa's Truth and Reconciliation Commission
… into conversation with each other in order to interrogate how the disabled body, in particular, became a site for nation building in South Africa's transition from apartheid to democracy in the 1990s. More specifically, this dissertation aims to explore how, framed by the Truth and …
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ENVELOPE ELEGY
… and our experiences are too varied. Thus, I interrogate what this might mean for the writer and the poetic experience more generally. By doing this, I ultimately interrogate what this means for me. However, I also accept T.S. Eliot’s claim that mature poetry has the unique ability to …
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Goodbye Now, Goodbye!
… course of a week in Autumn, the project seeks to interrogate notions of ambition, suffering, design, and salvation.</p>
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Vision and Revision: Demography, Maternal and Child Health Development, and the Representation of Native Women in Colonial Tanzania
… texts and at the colony level (Tanganyika), I interrogate the colonial numbers, the official and extra-governmental demographic indices, and analyze the texts and numbers produced about local-level Kilimanjaro. In reanalyzing early colony-level demographic data and analyzing a new database from …
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