Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Internalin"”.
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Faltungseigenschaften des extrazellulären Proteins Internalin J und seine Cysteinleiter
Internalin J (InlJ) gehört zu der Klasse der bakteriellen, cysteinhaltigen (leucine-rich repeat) LRR Proteine. Bei den Internalinen handelt es sich um meist invasions-assoziierte Proteine der Listerien. Die LRR-Domäne von InlJ ist aus 15 regelmäßig wiederkehrenden, stark konservierten …
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Das "Leucine-Rich Repeat" im Invasionsprotein Internalin B : Stabilität und Faltung eines Solenoidproteins
… zentrale LRR-Domäne des Invasionsproteins Internalin B (InlB241) des Bakteriums Listeria monocytogenes. Des weiteren sollten die Integrität und die Stabilitäts- und Faltungseigenschaften der sogenannten Internalin-Domäne (InlB321) untersucht werden. Hierbei handelt es sich um die bei allen …
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Identification and characterization of the inlGHE gene cluster of Listeria monocytogenes
… of Listeria monocytogenes EGD containing three internalin genes was identified and characterized. These genes, termed inlG, inlH and inlE, encode proteins of 490, 548 and 499 amino acids, respectively, which belong to the class of large, surface-bound internalins. Each of these proteins contains …
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STRUCTURAL AND FUNCTIONAL CHARACTERISATION OF MUCUS ADHESION PROTEINS OF LACTOBACILLUS REUTERI
… Lar0958 repeat shows structural similarity to internalin proteins of the pathogen Listeria monocytogenes. Taken together these results provide new insights into the structural organisation of lactobacilli mucus adhesins and their interaction with mucins, highlighting similarities with …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… cell types and induces its uptake by expressing internalin A and B, then secretes listeriolysin O (LLO), a virulence factor forming pores on the phagosome membrane to escape into the cytosol. Macrophages can phagocytose invading pathogens and induce innate inflammatory responses. Production of …
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CONTRIBUTIONS OF SIGMA-B AND PRFA TO STRESS RESPONSE AND VIRULENCE GENE EXPRESSION IN LISTERIA MONOCYTOGENES
… six virulence genes, including bsh and five internalin genes, to be controlled by sigmaB. Another protein that regulates virulence gene expression in L. monocytogenes is PrfA. I measured expression of PrfA-dependent and sigmaB-dependent genes under conditions that activate each regulator, …
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Regulation of hepatocyte growth factor receptor endocytic trafficking
… ligand HGF and the Listeria surface protein Internalin B (InlB). I characterized the mechanisms for InlB and HGF induced HGFR trafficking using a combination of imaging, molecular biological and biochemical approaches. First, I demonstrated that InlB and HGF were mechanistically equivalent in …
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Entwicklung neuartiger bakterieller Vektoren zur Übertragung von zellassoziierten Antigenen, DNA und RNA auf der Basis virulenzattenuierter L. monocytogenes
… Herkunft über das LPXTG-Ankermotiv von Internalin A. Die so erzielte starke Expression in der Zellwand setzte aber sowohl die Fitness der Bakterien als auch deren Invasivität in vitro deutlich herab und verhinderte damit eine effektive MHC-I-Präsentation des verwendeten Modellantigens. …
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How did Listeria monocytogenes become pathogenic?
… loci, as well as some virulence-associated internalin loci were compared among the six species. Phylogenetic analysis based on a data set of nucleic acid sequences from prs, ldh, vclA, vclB, iap, 16S and 23S rRNA genes identified L. grayi as the ancestral branch of the genus. This is …
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Novel antibody-based biosensors for the detection of haptens, proteins and whole cells
… all examined. The specific targets chosen were Internalin B@dB), an mnvasion-associated proteln of Listerla monocytogenes, parvovirus B19, the first human parvovirus and warfarin, the ninth most prescribed drug in the world. A panel of antibodies and antibody fragments directed against InlB …
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Essential features of a PrfA-dependent : promoter of Listeria monocytogenes
… regulates the expression of the small, secreted internalin C, was in-depth characterized by an in vitro transcription system to unravel the essential features of a PrfA-dependent promoter in this study. The obtained results indicate a dual promoter for inlC that leads to PrfA-dependent and …
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Characterization of virulence-attenuated Listeria monocytogenes common among food and food-associated environments but rarely associated with disease
… key virulence gene, inlA. The virulence factor Internalin A (InlA; encoded by inlA), facilitates the uptake of L. monocytogenes by epithelial cells that express the human isoform of E-cadherin and allows for pathogen traversal across the intestinal barrier in order to establish a systemic …