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Showing 1 to 1 of 1 for “"Internal amide bond"”.
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Synthesis of internal amide bond short interfering RNAs (siRNAs) and investigation of their gene silencing properties
… which catalytically cleaves the phosphate-oxygen bond, thus degrading the native RNA [3]. As such, there is widespread interest in chemically modifying the backbone of siRNAs in order to overcome some of the inherent problems with its native structure. There have been only two reports that have …