Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Intermittent hypoxia"”.
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Effects of Repetitive Intermittent Hypoxia after Acute and Chronic Spinal Cord Injury
Acute intermittent hypoxia (AIH – brief exposure to hypoxia alternating with normal O2 levels) is a promising potential therapy for spinal cord injury (SCI), which enhances spinal plasticity resulting in improved functional recovery. In this thesis, I assessed the effect of AIH on motor functional …
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An investigation into the effects of intermittent hypoxia on patients with essential hypertension
… air may be detrimental. studies have shown that intermittently breathing hypoxic air can be beneficial. Some of these benefits include increased red blood cell count, haemoglobin concentration, tissue capillarisation, and decreased heart rate. An interesting effect observed following intermittent …
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Development of a protocol to examine red blood cell functional adaptations to intermittent hypoxia
… protocol for investigating the effects of intermittent hypoxia (IH) on human red blood cell (RBC) physiology. While IH contributes to conditions such as sleep apnea and cardiovascular disease, its direct impact on RBC function remains poorly characterized. The protocol isolates IH exposure …
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The role of renal afferent signalling in chronic intermittent hypoxia-induced sympathoexcitation and hypertension
… are evident following exposure to chronic intermittent hypoxia (CIH) in addition to blunted baroreflex control of heart rate. However, little information is available about the baroreflex control of RSNA. In addition, because kidney injury disrupts renal afferent nerve signalling, changes …
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Functional Identification of Nucleus Tractus Solitarius (NTS) Barosensitive Neurons: Effect of Chronic Intermittent Hypoxia (CIH)
Chronic Intermittent Hypoxia (CIH) is a model used to study obstructive sleep apnea (OSA). Previously, we showed that baroreflex control of heart rate (HR) (baroreflex sensitivity) is reduced in CIH rats. While afferent function and HR in response to vagal efferent stimulation are enhanced, the …
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Prenatal Programming of Hepatic Glucose and Cholesterol Regulation in Male Rat Offspring by Chronic Intermittent Hypoxia
… sleep. Sufferers of OSA are exposed to chronic intermittent hypoxia (CIH), characterized by cyclical reductions in oxygen availability. A number of studies have established a link between OSA and various cardiovascular and metabolic comorbidities in adulthood, including hypertension, obesity, …
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Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow with Exposure to Intermittent Hypoxia in Humans
Background: Intermittent hypoxia (IH) simulating obstructive sleep apnea raises blood pressure (BP) and impairs cerebral blood flow response. The pathophysiology of intermittent hypoxia-mediated increase in BP involves multiple mechanisms but the role of cyclooxygenase (COX) catalyzed vasoactive …
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Effects of Chronic Intermittent Hypoxia, Acute and Chronic Exercise on Skeletal Muscle Na+,K+ATPase, Buffering Capacity and Plasma Electrolytes in Well-Trained Athletes
… athletes, about the effects of chronic intermittent hypoxia, acute and chronic exercise on skeletal muscle Na+,K+ATPase, buffering capacity and plasma electrolytes. Thus the effects of acute exercise and these interventions in well-trained athletes are the focus of this thesis.
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Oscillations in microvascular flow : their relationship to tissue oxygenation, cellular metabolic function and their diagnostic potential for detecting skin melanoma - clinical, experimental and theoretical investigations
… two widely observed characteristics of cancer, intermittent hypoxia and altered cellular energy metabolism. The former is explored through the analysis of blood flow and oxygenation data recorded during dry static apnoea, whilst the latter is modelled using coupled phase oscillators.
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Investigating Central Chemoreception-based Biomarkers of Sudden Unexpected Death in Epilepsy (SUDEP)
… to recover from postictal hypercapnia and hypoxia (HH) is a critical risk factor for SUDEP. Central chemoreception initiates adaptive cardio-respiratory and autoresuscitation responses to HH changes, and is impaired in epilepsy and SUDEP. We have reported that the Kcna1-/- (KO) model of …
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Ceramides as Therapeutic Targets in Bronchopulmonary Dysplasia
… days [PND] 1-7 and 60% O₂ PND 7-14) followed by intermittent hypoxia from PND 14-21 (termed the HIH BPD-like lung injury model). Lung injury in this model was characterized by hypoplastic pulmonary vasculature, pulmonary hypertension, and "emphysematous" lung structure due to inhibited …
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Physical Activity-Associated Differences in Placental Lipid Profiles and Docosahexaenoic Acid Uptake: Insights from Lipidomics and an In Vitro Exercise Model
… trophoblast cells were exposed to bouts of intermittent hypoxia (IH) and high shear stress as proxies for PA. Hypoxia was considered 3% and normoxia 10% O2. Low shear stress was defined as 1 dyn/cm2 and high shear stress as 3 dyn/cm2. DHA was added to the cell culture media, and uptake into …
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Global Gene Expression Profiles and Proteomic Assessments in Adult Females with Obstructive Sleep Apnea Syndrome
… airway collapse during sleep, causing subsequent intermittent hypoxia, hypercapnia, and fragmented sleep and is also associated with significant morbidity including daytime sleepiness, hypertension, and elevated cardiovascular risk. OSAS affects at least 4% of men and 2% of women; unfortunately, …