Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Interleukin-7 Receptor"”.
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Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in Humans and In Vitro differences between genetically stratified subjects based on Interleukin-7 Receptor Genotype
Multiple Sclerosis is an autoimmune disease mediated by activated lymphocytes entering the central nervous system. Treatments with the greatest efficacy either prevent the entry of activated lymphocytes, or deplete the lymphocyte population, before allowing lymphocyte reconstitution. IL-7Rα was …
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A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line
… one component of the heterodimeric IL-7R[alpha] receptor, and signaling through this receptor is essential for murine T and B cell development as well as human T cell development. IL-7R[alpha] signaling is also responsible for homeostatic proliferation of T cells in lymphopenic hosts, as well as …
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Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
… Upon activation, their immunoglobulin B cell receptor (BCR) is secreted as antibody to neutralise pathogens or mediate the immune response. A diverse repertoire of immunoglobulin molecules is therefore essential for immune surveillance. As we age however, antibody diversity declines, as does …
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Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development
… recombination. This assembles a complete B cell receptor (BCR) and is the primary step in producing a diverse BCR repertoire; an essential requirement for a robust adaptive immune response. The roles of interleukin-7 receptor, pre-BCR and chemokine receptor type 4 signalling are well established …