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Showing 1 to 20 of 48 for “"Interleukin-4"”.
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Spezifische Hemmung der allergieassoziierten Interleukin-4 Signaltransduktion
Das Cytokin Interleukin-4 (IL-4) ist ein essentieller Faktor bei der Entstehung von Sofort-Typ Allergien. Die Bindung von IL-4 an seinen Rezeptor und die anschließende Phosphorylierung des IL-4 aktivierten Transkriptionsfaktors Stat6 ist ein Schlüsselereignis bei der allergischen Immunantwort. In …
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The Cross-Talk Between Neurons and Microglia Through Interleukin-4 After Ischemic Injury
… and release a potent anti-inflammatory cytokine, interleukin(IL) -4. We propose that this neuronal response to sublethal ischemia is designed to guide surrounding microglia/macrophages to a reparative and anti-inflammatory (M2) phenotype.</p> <p>The research included in this study is designed to …
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The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling
… signaling is a dominant component. Recently, Interleukin (IL)-4 has been shown to play an important role in determining the fate of Foxp3+ Tregs. In vivo, IL-4-mediated signaling via Interleukin-4 receptor alpha (IL4Rα) was convincingly shown to mediate Treg transdifferentiation into ex-Foxp3 …
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The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection
Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N. brasiliensis) and Schistosoma mansoni (S. manson!) infection. Among other cell types, IL-4Ra responsive smooth muscle …
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Role of 5-Lipoxygenase in Interleukin-4-Induced Oxidative Stress and Inflammation in Vascular Endothelium
… yet completely understood. Recently, the role of interleukin-4 (IL-4) in atherogenesis became controversial and gained attention. IL-4 is a pleiotropic immunomodulatory cytokine secreted by T-helper 2 (Th2) lymphocytes, eosinophils, and mast cells. It was traditionally believed to be an …
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Type 2 Diabetes Impairs Interleukin-4 Function in Macrophages and Amplifies the Brain-Based Neuroimmune Response
Neuroimmunity is mediated by activated macrophages that secrete proinflammatory cytokines in response to immune insult. These messenger molecules communicate immune status to the brain to elicit important metabolic and behavioral changes that act to minimize transmission of infection and maximize …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… leading cause of allergic disease pathogenesis. Interleukin-4 induced gene 1 (IL-4i1) is a secreted L-amino acid oxidase enzyme mainly expressed by antigen-presenting cells (APCs) and upon activation by IL-4 and CD40, can be induced in B lymphocytes. IL-4i1 converts phenylalanine into …
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Investigating the T cell-specific role of Interleukin-4 receptor alpha (IL-4Rα) in tuberculosis (TB)
Protective immunity to tuberculosis (TB) is dependent on the ability of the host to mount a robust T cell response. The main effector T cells which contribute to protection in TB include T helper (Th) Th1 and Th17 T cells. The Th2 response, associated with IL-4Rα mediated signalling, remains …
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Expression und Aufreinigung von intrazellulären Anteilen des Interleukin-4-Rezeptors als GST-Fusionsproteine und Messung von Protein-Protein-Wechselwirkungen
In dieser Doktorarbeit wurden zwei intrazelluläre Anteile des IL-4 Rezeptors als GST-Fusionsproteine exprimiert. GST-E1, in dem das cytoplasmatische membranproximale 1/3 von IL-4Ralpha (173 AS) einschließlich des Box 1 Motivs an GST fusioniert ist, konnte nach differenzierter De- und Renaturierung …
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Characterization of interleukin-4 induced gene-1 (IL-4I1) as a host immunoregulator to cutaneous leishmaniasis in cell based models
Macrophage activation can be split into two distinct groups: Classically-Activated (M1) and Alternatively-Activated (M2) macrophages. Each are associated with a certain immune response; in the context of cutaneous leishmaniasis caused by infection with Leishmania major. Specifically, M1 macrophages …
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Die Bedeutung der Expression des IL-4 Rezeptors für die Prognosestellung beim lokal begrenzten Nierenzellkarzinom
… nachgewiesen, daß Zellen des Nierenzellkarzinoms Interleukin-4 Rezeptoren exprimieren. Inwieweit dieser Umstand sich auf das biologische Verhalten des Tumors auswirkt, ist bislang jedoch nicht geklärt. Die vorliegende Arbeit beschäftigt sich mit der Frage, ob es eine Korrelation zwischen dem …
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Peripheral Blood Mononuclear Cells Cytokine Expression in Horses Treated with Dexamethasone
… in horses on mRNA cytokine expression, including interleukin-1Î , interferon-gamma, interleukin-4 and interleukin-6, during a five day treatment period and a five day post treatment period. A randomized complete block design was performed on 16 healthy horses. Group I (8 horses) received 0.1 mg/kg …
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In Vivo Studies of the Foreign Body Reaction to Biomedical Polymers
… immunodeficient mice mainly targeting IL-4 (interleukin-4) cytokine. The experiment consisted of in vivo subcutaneous implants of polyether urethane (PEU) and polyethylene terephthalate (PET) in immunodeficient mice strains. Analysis on polymer surfaces using quantitative calculations such as …
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Induction of anti-ergotamine antibodies in mice and steers and protection against fescue toxicosis in mice
… fed EF diets. Production of interferon gamma and interleukin-4 was higher by splenocytes from mice fed EI diets, whereas interleukin-2 tended to be lower. Fescue toxicosis may stimulate T helper cell 2 subset of CD4⁺ T cells. The T<sub>H</sub>2 subset may augment humoral immune responses to …
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THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY
T helper 2 (Th2)-related interleukin 4/13 pathway genes have been associated with asthma susceptibility; however the role of these genes in asthma severity has not been explored. We tested single nucleotide polymorphisms (SNPs) in the critical Th2 regulator GATA-binding protein 3 (GATA3) and other …
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Biomarkers of oxidative stress and inflammation in biological samples collected from recurrent airway obstruction (RAO)-affected horses and their controls
… isofurans, amino acids and mRNA expression of interleukin 4 (IL4), gamma interferon (INFγ), inducible nitric oxide synthase (iNOS), extracellular glutathione peroxidase (GPx-3), and cytosolic superoxide dismutase (SOD-1) were not significantly different or were at the limits of detection. …
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Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection
… animals, however, expressed Th2 genes such as interleukin-4 and arginase-1. Results from these two experiments indicate an adaptive immune response as early as 3 days post challenge infection in hair sheep. Thus, the rapid protective immunity generation of parasite-resistant hair sheep is a key …
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