Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Interleukin-33"”.
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The role of Interleukin-33 in retinal degenerative diseases
… such as diabetic retinopathy (DR).<br/><br/>Interleukin-33 (IL-33) is expressed in the nuclei of Müller cells in the healthy retina. This cytokine has diverse roles in immunity and inflammation, although its role in Müller cell pathophysiology remains largely unknown. This PhD project has …
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The role of mucus in the cross talk between gut bacteria and the host
… Moreover, TCRδ-/- mice showed reduced levels of interleukin-33 mRNA, a mediator of mucosal healing. An ex vivo SI organoid model using input cells from TCRδ-/- mice showed, upon addition of keratinocyte growth factor, increases in crypt length, and both goblet cell numbers and redistribution. …
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Ambient particulate matter as a trigger for acute exacerbations of asthma
… cytokines and Th2 promoting cytokines such as interleukin (IL)-33. Treatment with dietary antioxidants three times during the final week of chronic challenge, prior to delivery of Sydney PM10, was not effective in abrogating the inflammation induced by particulate matter. However, …
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The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis
… in inflammatory cytokine/chemokine mRNA (interleukin-33 (IL-33), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-alpha (TNF-α)) was observed in cardiac fibroblasts treated with ethanol.</p>
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Immunomodulation in Adenovirus-Induced Viral Hepatitis
… versus persistence. Immune modulation with interleukin 33 (IL-33) and hepatocytes growth factor (HGF) have great potential for developing therapeutic strategies. The liver produces and releases IL-33 and HGF upon viral infection, two molecules that favor hepatocyte survival by up-regulating …
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Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… with asthma. The recently discovered cytokine, interleukin 33 (IL-33), is thought to play an important role in a variety of autoimmune diseases; including asthma and atopic dermatitis. The aims of this study were to investigate the interaction of mast cells and HASM cells in vitro, analysing the …
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Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis
… also be studied including TGF-β, BMP7 and IL-33. Results showed that phytoestrogens genistein and daidzein significantly reduced prostate cancer cell viability (PC3 cells) with concentration 10-7 M (15 %, P = 0.01) and 10-6 M (11%, P = 0.04) for genistein and for daidzein the decrease in cell …
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Evaluation of immunomodulatory mediators in chronic obstructive pulmonary disease and cardiovascular disease
… in both COPD and CVD. Firstly, the Interleukin-33 (IL-33)/ST2 axis and secondly, specialised pro-resolving mediators (SPMs), specifically the specialised pro-resolving mediator Resolvin D1. Additionally, data pertaining to the anti-platelet drug aspirin in people with COPD was …
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Astrocytic Sonic Hedgehog signalling in development and disease
… I identified a synaptic phenotype in Il33-/- animals that mirrors the synaptic abundance seen in mutants with impaired astrocytic Shh signalling. Specifically, I show an increase in pre-synaptic puncta in layer V neurons following Il-33 loss, which I attribute to disrupted synapse …