Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Interleukin-27"”.
-
Molecular Mechanisms of Protection from Hepatitis C Infection
… with resistance to HCV was strongest for Interleukin-27 (IL-27) which was significantly upregulated in EU compared to the 2 other groups and C X C motif chemokine 7 (CXCL7) which was significantly upregulated in EU relative to the CHCV group. The CD28 mediated T-helper cell signalling …
-
UNDERSTANDING PLACENTAL IMMUNITY: CYTOKINE CONTROL OF CONGENITAL VIRAL INFECTION
… Within this dissertation, we identified Interleukin 27 (IL-27) as a novel antiviral cytokine at the maternal-fetal interface with a breadth of activity against different emerging viruses. We examined the protective effects of placental IL-27 signaling using an in vivo mouse model of …
-
Tumor Immunotherapy: Mechanisms of Acquired Resistance and Characterization of Immune Related to xicities
… hepatitis. Once activated, these cells produce interleukin-27 that is required for liver toxicity. CD8 T cells infiltrate the liver in response to this myeloid activation and mediate tissue damage. Co-administration of CTLA-4 and/or CCR2 blockade may minimize hepatitis, but yield equal or …
-
Novel cytokines in innate immunity: IL-27 and IL-30 enhance responsiveness to gram-negative bacterial components in human myeloid cells
… thesis investigates two related cytokines, IL-27 and IL-30, to identify novel proinflammatory mechanisms to improve treatments for bacterial infections. IL-27 is comprised of IL-27p28 and EBI3 subunits; the IL-27p28 subunit, also named IL-30, can also signal independently of EBI3. To date, most …