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Showing 1 to 20 of 40 for “"Interleukin-2 (IL-2)"”.

  1. Herstellung und funktionelle Analyse von Immunzytokinen, die Interleukin-2 (IL-2) oder Granulozyten/Makrophagen Kolonie-stimulierenden Faktor (GM-CSF) enthalten, zur Verbesserung einer NDV-modifizierten Tumorvakzine

    Aigner, MaximilianUniversität Heidelberg

    … und funktionellen Analyse neuartiger, IL-2- bzw. GM-CSF-enthaltender bi- und trispezifischer single-chain Antikörper (Immunzytokine) zur Verbesserung der antitumoralen Immunantworten bei Krebspatienten. Die Arbeit ist thematisch in ein Projekt zur Entwicklung einer aktiv-spezifischen …

    heid-diss Repository record

  2. Analysis of trafficking dynamics and cellular response in the interleukin-2 ligand/receptor system

    Fallon, Eric Michael, 1972-Massachusetts Institute of Technology2000

    Interleukin-2 (IL-2) has been widely studied as a protein therapeutic due primarily to its central role in potentiating cell-based immunity. The effects of IL-2 on its cellular targets are mediated solely through interaction with one or more forms of the IL-2 receptor (IL- 2R). The overall goal of …

    mit Repository record

  3. The potential role of interleukin-2 in impaired cell-mediated immunity of iron deficiency

    Helyar, LesleyUniversity of Illinois at Urbana-Champaign2011

    … impairs cell-mediated immunity, which is primarily dependent on T-lymphocyte functions including production of the cytokine, interleukin 2 (IL-2). The potential role of IL-2 production and responsiveness in impaired cell-mediated immunity of iron deficiency was investigated in a series of …

    uiuc Repository record

  4. Ex Vivo Expanded Cord Blood Natural Killer Cells As A Novel Therapeutic For Multiple Myeloma

    Shah, Nina2015

    … and, to date, is incurable. Allogeneic natural killer (NK) cells are active in various hematologic malignancies and may have a role against MM. Umbilical cord blood is a potential source for allogeneic NK cells and <em>ex vivo</em> expanded umbilical cord blood-derived NK (CB-NK) cells …

    uthsc Repository record

  5. Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells

    Bradley, Michael JosephVirginia Tech1997

    … the hypothesis that activation of natural killer (NK) or lymphokine activated killer (LAK) cells induces the expression of FasL, perforin, and CD44 which together contribute towards increased cytolytic activity. To this effect, we used wild-type mice, perforin-knockout mice, and mice lacking …

    vt Repository record

  6. T cell mediated satellite cell function: implications for age-associated changes in skeletal muscle regeneration

    Dumke, Breanna R., author, Lees, Simon J., advisor, Gotshall, Robert W., advisor, Frye, Melinda A., committee memberColorado State University. Libraries2010

    … for 48 hours with co-stimulation of 100 IU/ml Interleukin-2 (IL-2) and 5 ug/ml of anti-CD28. Co-stimulation increased 5-bromo-2'-deoxyuridine (BrdU) incorporation (proliferation) of T cells from 13.382% (SEM=4.55, n=5) in control to 64.77% (SEM= 6.02, n=5). Additionally, T cell cytokines …

    colostate Repository record

  7. Harnessing the manufacturing power of the plant system : production of recombinant human interleukin-2 in Nicotiana benthamiana

    Matakas, Jason Daniel2011

    … In this thesis, I have explored the feasibility of producing recombinant human interleukin-2 (IL-2) in the green tissues of transgenic Nicotiana benthamiana (tobacco). IL-2 is a biopharmaceutical of great importance as it is the standard immunotherapeutic treatment for late-stage metastatic …

    msu Repository record

  8. Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination

    Pressley, Jennifer SparkmanVirginia Tech2005

    … are tolerogenic in tumor-burdened animals, and fail to lyse neoplastic cells. Our goal was to investigate the kinetics of immune dysfunction related to tumor-burdened host (TBH) memory T cell responses (or the lack thereof). We demonstrate tumor growth impairs T cell activation by modulating CD4+ …

    vt Repository record

  9. Engineering Intratumoral Cytokine Therapies for Cancer

    Lutz, Emi A.Massachusetts Institute of Technology2022

    … (alum) particles, greatly improved their tolerability and efficacy. The improved efficacy of alum-anchored IFNs could be attributed to sustained pleiotropic effects on tumor cells, immune cells, and non-hematopoietic cells. Alum-anchored IFN therapies were curative upon combination with either …

    mit Repository record

  10. Role of autocrine growth factors in the tumorigenic transformation of T cells

    Hassuneh, Mona RushdiVirginia Tech1996

    … resulting from constitutive expression of interleukin-2 (IL-2) and interleukin 2 receptor (IL-2R) genes. Such cell lines could induce tumors <i>in vivo</i> and furthermore, the growth of such transformed cells both <i>ex vivo</i> and <i>in vivo</i> could be inhibited by monoclonal …

    vt Repository record

  11. Intracellular Signaling Networks in the Immune Response: Pathways Activated by Interleukin-2 and Interleukin-4 Receptors and their Roles in T Cell Proliferation

    Comfort, Kristen Krupa2006

    … migration, and survival. The cytokines interleukin-2 (IL-2) and interleukin-4 (IL-4) are key regulators of the adaptive immune system, particularly influencing the clonal expansion and differentiation of T cells. At least in culture, both synergistic and antagonistic effects of IL-2 and …

    ncsu Repository record

  12. IL-2-Dependent Regulation of Immune Homeostasis and Response to Infection

    Hayes, Erika Therese2021

    Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its impact on both regulatory T (Treg) and effector T (Teff) cells. However, the precise role of IL-2 in the homeostatic maintenance and function of Treg cells in the adult peripheral immune system remains unclear. Here, we …

    washington Repository record

  13. Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells

    Hagan, Kristan Andrea2013

    … 1 memory development by positively regulating interleukin-2 (IL-2) expression, a hallmark cytokine of central memory CD4⁺ T cells. The present work seeks to delineate how signaling through the interferon alpha/beta receptor promotes IL-2 secretion in murine CD4⁺ T cell. IL-2 provides an …

    utswmed Repository record

  14. Combination Therapy With Aerosol Il-2 and Nk Cells For The Treatment of Osteosarcoma Lung Metastasis

    Guma, Sergei R2014

    … to evaluate the efficacy of combining natural killer [NK] cell therapy with aerosol interleukin-2 [IL-2] for the treatment of osteosarcoma lung metastasis. The expression of NKG2D ligands was analyzed in five different human osteosarcoma cell lines and 103 patient samples (47 from primary tumors …

    uthsc Repository record

  15. Contribution to the elucidation of the anti-inflammatory activity of Sesquiterpene Lactones

    García-Piñeres, Alfonso J.

    … of the p65 and p50 subunits was compared. While NEM inhibited the binding of both, SLs only prevented binding of p65, being more selective. The inhibition by NEM relied on alkylation of Cys38 in p65, or its equivalent in p50. <br>A densitometric method for the quantification of EMSA analyses …

    freiburg-diss Repository record

  16. The effects of vitamin A deficiency on the immune system in a murine model of systemic lupus erythematosus

    Liao, C. HuaUniversity of Illinois at Urbana-Champaign2011

    … assigned to either the A$-$ or A+ groups, while twenty-four +/+ mice, of the same sex and age range as MRL/l, were assigned to the normal control group (+/+ group). The results of both studies showed that vitamin A deficiency had a significant effect on preventing the MRL/l mice body weight …

    uiuc Repository record

  17. The immunomodulatory properties of AZT used in the treatment of AIDS

    McKallip, Robert JamesVirginia Tech1994

    … Interestingly, after the i.p. administration of interleukin-2 (IL-2) simultaneously with AZT, the total cellularity of the thymus was completely reconstituted. We also observed that AZT effectively suppressed the in vivo T cell response to conaibumin and gp120 of HIV. Furthermore, the addition of …

    vt Repository record

  18. Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity

    Leichner, Theresa Marie2016

    … Treg numbers are known to rely on the cytokine interleukin-2 (IL-2) and T cell receptor (TCR) signals. We found that Foxp3- conventional T cells (Tconvs) produce IL-2 in response to self-peptides and that Tconvs possessing TCRs with greater self-reactivity express more IL-2 at baseline. …

    penn Repository record

  19. Retroviral-mediated gene transfer of Il-1β?cDNA into human activated T cells

    Ruhl, Elizabeth2015

    Autologous activated T cells (ATC) are being utilized in clinical trials as potential mediators of anti-tumor cytotoxicity in refractory cancer patients who suffer from hematologic malignancies or solid tumors. ATC are readily generated from peripheral blood and possess non-major histocompatibility …

    wayne-thes Repository record

  20. Investigating Cognitive/Affective/Sleep disturbance symptoms in Patients Receiving High-Dose Interleukin-2 Therapy

    Mann, Tara2018

    … intensive treatments for life-limiting chronic illnesses such as cancer often experience severe cognitive, affective, and sleep disturbance symptoms. Immunotherapies such as high-dose Interleukin-2 (IL-2) can result in severe alterations in cognition, affect, and sleep. These alterations not …

    duke Repository record

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