Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Interleukin-2"”.
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Engineering persistent interleukin-2 for cancer immunotherapy
… are stimulated to proliferate by the cytokine interleukin-2 (IL-2). Consequently, IL-2 has been actively pursued as an agent for immunotherapy, either alone or in combination with other therapeutic strategies. IL-2 is characterized by rapid systemic clearance, with a fast-phase serum half-life …
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Interleukin-2 Engineering for improved therapeutic effectiveness
(cont.) (K[d] [approximately] 10pM) for its private alpha receptor subunit, unlike wild-type IL-2 (K[d] [approximately] 10 nM). IL-2 mutants with picomolar affinity for IL-2Rα stimulate T cell growth responses quantitatively equivalent to those mediated by IL-15. Our results suggest that the …
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Die Rolle der bakteriellen Darmflora in der Kolitis der Interleukin-2 defizienten Maus
… der der Rolle von T-Zellen in der Kolitis der Interleukin-2 defizienten Maus (IL-2-/-) und der Beteiligung der physiologischen Darmflora an der Pathogenese. Die Untersuchungen der mRNA-Expression im Kolon ergaben, daß die Kolitis der IL-2-/- Maus durch die Zytokine TNF-α, IFN-γ und IL-1 …
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Investigating Cognitive/Affective/Sleep disturbance symptoms in Patients Receiving High-Dose Interleukin-2 Therapy
… symptoms. Immunotherapies such as high-dose Interleukin-2 (IL-2) can result in severe alterations in cognition, affect, and sleep. These alterations not only prevent patients from receiving their full course of treatment but also severely impact the quality of life of patients and their care …
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Precision Cytokine Therapy: Engineering and Delivery of CD8- and CAR-Tropic Interleukin-2 Variants
… in the brain by expressing modified versions of interleukin 2 (IL2), a key T cell growth factor, using an adeno-associated viral (AAV) gene delivery system. Previous work by Yshii et al. (2022) demonstrated that AAV-mediated expression of wild type IL2 in the brain expanded immunosuppressive CD4+ …
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The potential role of interleukin-2 in impaired cell-mediated immunity of iron deficiency
… functions including production of the cytokine, interleukin 2 (IL-2). The potential role of IL-2 production and responsiveness in impaired cell-mediated immunity of iron deficiency was investigated in a series of experiments. Immune parameters were measured in unstimulated and concanavalin A (Con …
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Analysis of trafficking dynamics and cellular response in the interleukin-2 ligand/receptor system
Interleukin-2 (IL-2) has been widely studied as a protein therapeutic due primarily to its central role in potentiating cell-based immunity. The effects of IL-2 on its cellular targets are mediated solely through interaction with one or more forms of the IL-2 receptor (IL- 2R). The overall goal of …
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Long-Term Survival In Metastatic Melanoma Patients With Leptomeningeal Disease Treated With Intrathecal Interleukin-2
… assessed the safety and efficacy of intrathecal interleukin-2 (IT IL-2) in metastatic melanoma patients with LMD.</p> <p><strong>METHODS:</strong> We reviewed the outcomes of 43 consecutive metastatic melanoma patients with LMD who were treated with IT IL-2 from 2006 to 2014 in a Compassionate …
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Targeting Inflammation in Atherosclerosis: The Role of Low-dose Interleukin 2 in Acute Coronary Syndromes
… role in ACS, promoting healing and repair.6 Interleukin 2 (IL-2) is central to Treg cell development and expansion.7 Whilst low-dose IL-2 therapy has been successfully used in autoimmune and inflammatory conditions, its use is currently contraindicated in severe IHD.8 In the LILACS (low-dose …
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Immunotherapeutic alteration of tumor-induced suppression of interleukin 2 and 3 production by Propionibacterium acnes vaccination
… P. acnes-induced cytotoxic T cells arise via the Interleukin cascade. Therefore, this study investigated the involvement of Interleukin 2 (IL 2) and Interleukin 3 (IL 3), known components of the Interleukin cascade, in local P. acnes-mediated anti-tumor action. A 500 ug dose of heat-killed …
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Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
… 1 memory development by positively regulating interleukin-2 (IL-2) expression, a hallmark cytokine of central memory CD4⁺ T cells. The present work seeks to delineate how signaling through the interferon alpha/beta receptor promotes IL-2 secretion in murine CD4⁺ T cell. IL-2 provides an …
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Harnessing the manufacturing power of the plant system : production of recombinant human interleukin-2 in Nicotiana benthamiana
… the feasibility of producing recombinant human interleukin-2 (IL-2) in the green tissues of transgenic Nicotiana benthamiana (tobacco). IL-2 is a biopharmaceutical of great importance as it is the standard immunotherapeutic treatment for late-stage metastatic melanoma and renal cell cancers. …
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Synergistic anti-tumor immune response to combination immunotherapy consisting of anti-tumor antibodies, extended half-life Interleukin-2, and other immunomodulatory agents
Cancer immunotherapies under development have generally focused on either stimulating T-cell immunity or driving antibody-directed effector functions of the innate immune system such as antibody-dependent cell-mediated cytotoxicity (ADCC). However, as our understanding of antitumor immune responses …
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Herstellung und funktionelle Analyse von Immunzytokinen, die Interleukin-2 (IL-2) oder Granulozyten/Makrophagen Kolonie-stimulierenden Faktor (GM-CSF) enthalten, zur Verbesserung einer NDV-modifizierten Tumorvakzine
Die vorliegende Dissertation befasst sich mit der Herstellung und funktionellen Analyse neuartiger, IL-2- bzw. GM-CSF-enthaltender bi- und trispezifischer single-chain Antikörper (Immunzytokine) zur Verbesserung der antitumoralen Immunantworten bei Krebspatienten. Die Arbeit ist thematisch in ein …
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Kostnaðarvirknigreining á árangri nýrnakrabbameinslyfsins IL-2
… á því að hefja notkun á nýrnakrabbameinslyfinu Interleukin 2. Til þess að meta það verður notast við kostnaðarvirknigreiningu. Ritgerðinni er skipt niður í nokkra kafla. Fyrsti kaflinn er inngangurinn. Annar kafli fjallar almennt um krabbamein. Í þriðja kafla eru taldir upp áhættuþættir …
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The Effects of Biological Response Modification and Diet on the Immune Respose of Tumor-bearing mice
… were treated In vitro with mouse interferon, rat interleukin-2, 2-amino-5-bromo-6-methyl-4-pyrimidinone (ABMP), Prostaglandin E<sub>1</sub> (PGE<sub>1</sub>), singly and in combination, for 2 hours prior to mixing with target cells. Treated spleen cells from Diet 1 tumor-bearing animals at 3-6 …
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Role of autocrine growth factors in the tumorigenic transformation of T cells
… resulting from constitutive expression of interleukin-2 (IL-2) and interleukin 2 receptor (IL-2R) genes. Such cell lines could induce tumors <i>in vivo</i> and furthermore, the growth of such transformed cells both <i>ex vivo</i> and <i>in vivo</i> could be inhibited by monoclonal …
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Engineering Secreted Proteins for Gene Transfer and DNA Vaccination
… (SRUC), was engineered by fusing the human interleukin-2 signal peptide to <em>Renilla</em> luciferase. We further modified the <em>Renilla</em> luciferase gene using site-directed-mutagenesis to obtain a mutant form of<em> Renilla</em> luciferase, SRUC3, with dramatically improved …
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Induction of anti-ergotamine antibodies in mice and steers and protection against fescue toxicosis in mice
… fed EF diets. Production of interferon gamma and interleukin-4 was higher by splenocytes from mice fed EI diets, whereas interleukin-2 tended to be lower. Fescue toxicosis may stimulate T helper cell 2 subset of CD4⁺ T cells. The T<sub>H</sub>2 subset may augment humoral immune responses to …
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