Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Interleukin-11"”.
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Struktur- und Funktionsuntersuchungen am humanen Interleukin-11-Rezeptorkomplex
Interleukin-11 (IL-11) belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines, which all share the glycoprotein gp130 as a signal transducing receptor component. IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) alpha-subunit (IL-11R-alpha). The third …
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Struktur- und Funktionsanalyse der zytokinbindenden Domäne des humanen Interleukin-11-Rezeptors
The interleukin-11 receptor (IL-11R) belongs to the hematopoietic receptor superfamily. The functional receptor complex comprises IL-11, IL-11R and the signal-transducing subunit gp130. The extracellular part of the IL-11R consists of three domains: an N-terminal immunoglobulin-like domain, D1, and …
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
… carcinoma (PTC). In gene expression screens, interleukin-11 was identified as a RET-responsive gene. We sought to characterize the expression of IL-11 in response to activation of the RET receptor, and determine how IL-11 might contribute to RET-mediated cell behaviours. Analysis of HEK293 …
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
… Our laboratory examined wild-type (WT) and BCL11B knockout (BSMKO) mice treated with Angiotensin II (AngII) for a period of 7 days. The BSMKO mice given AngII exhibited aneurysm formation, while the WT mice did not show this response. RNA sequencing of entire aortas from BSMKO mice and WT mice …
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Investigating the molecular underpinnings of major depressive disorder and the utility of biomarkers in the inflammatory cytokine pathway as aids for clinical diagnosis and treatment selection
… cytokine pathway, and DNA methylation in interleukin-11<br/>could be used to predict antidepressant response amongst MDD patients.<br/>Moreover, transcription of ATP-binding cassette sub-family F member 1 was<br/>found to increase on antidepressant treatment, with the magnitude of …
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Investigating the Actions of Interleukin-6 Family Members on Post-Hatching Blastocyst Development in Cattle
… if supplementing selective members of the interleukin 6 (IL6) cytokine family influences post-hatching in vitro produced (IVP) bovine blastocyst development. The first series of studies determined if adding human recombinant IL6 improved IVP blastocyst quality before and after …
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Color stability and phenolic composition from corn pericarp extracts in a beverage model and protective and anti-inflammatory potential of anthocyanin-rich plant extracts on celiac disease in vitro
… 0.14 and 0.22 fold increase (FI) respectively on interleukin (IL) 6, RAW had a 4.3 FI on IL-11, and PAWE exhibited a 0.35 FI on metallopeptidase inhibitor 2 (TIMP-2) (p<0.05). Interleukin 11 and TIMP-2 are anti-inflammatory while IL-6 can be both anti- or pro-inflammatory and GM-CSF is …
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Cytokines and human endometrial function: Abnormalities in recurrent miscarriage women.
… expression of leukaemia inhibitory factor (LIF), interleukin-6 (IL-6), interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta) and tumour necrosis factor alpha (TNFalpha) in the human endometrium of normal fertile women throughout the menstrual cycle. The results showed that staining …
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STAT-3-Aktivierung in humanen endometrialen Primärzellkulturen durch LIF und IL-11
Leukemia inhibitory factor (LIF) and Interleukin (IL) 11, two cytokines of the IL-6 Family, have been identified as regulatory molecules during blastocyst implantation in mice. IL-11 knock out (k.o.) mice, as well as LIF Rß k.o. mice demonstrated fertility problems. Thus the hypothesis was …
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Untersuchungen zur Zytokinbindung und Rezeptoraktivierung des Signaltransduktors gp130 durch seine Liganden IL-6 und IL-11
… dimer in complex with IL-6/IL-6R and IL-11/IL-11R. - The three membrane-proximal domains of gp130 (D4, D5 and D6) are responsible for the activation of the receptor. The deletion of D4 and D6 of gp130 leads to a partial loss of the cytokine binding affinity due to a conformational change. …