Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"Interleukin-1"”.
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Macrophage Response to Interleukin-1 Stimulation and the Nature of Cell Surface Interleukin-1 Alpha
Interleukin-1α (IL-1α) is a potent cytokine involved in a range of diseases and can be found expressed on the cell surface (csIL-1α) and in the soluble form, signalling through the type I IL-1 receptor (IL-1R1). IL-1 signalling leads to increased secretion of cytokines, recruitment of immune cells …
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An Evaluation of Two Interleukin-1 Assays
Interleukin-1 (IL-1) is produced by macrophages and has been shown to be an important protein involved in the regulation of an immune response. Several methods of detecting IL-1 in the supernatant of macrophage cultures have been developed. The purpose of this project was to evaluate two of these …
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Der Interleukin-1-Genkomplex in der Schizophrenie
… drei genetische Polymorphismen in Genen des Interleukin-1-Genkomplexes auf eine mögliche Assoziation mit Schizophrenie untersucht: die Gene, die für die proinflammatorischen Interleukine Interleukin-1 alpha und Interleukin-1 beta kodieren, sowie das Gen, welches für den antiinflammatorischen …
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Regeneration of cartilage glycosaminoglycan after degradation by interleukin-1
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2001.
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Transport of interleukin 1[beta] in calf epiphyseal cartilage
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Association of the Interleukin-1 beta and Interleukin-1 Receptor Accessory Protein Gene Polymorphisms with Persistent Hepatitis B Virus Infection and Hepatocellular Carcinoma
… are probably related to host immune factors. Interleukin-1β (IL-1β) plays significant roles in inflammation and immune defense via IL-1 receptor accessory protein (IL-1RAcP). We investigated whether genetic polymorphisms of IL-1B and IL-1RAcP genes are associated with persistent HBV infection …
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Recombinant Equine Interleukin-1 Induced Models of Equine Joint Disease
… quality of life. The pro-inflammatory cytokine interleukin-1 (IL-1) has been associated with the initiation and pathogenesis of joint disease. In part, this occurs by induction of proteases and oxidative pathways that contribute to the degradation of structural components of the articular …
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Roles of interleukin-1 beta in glutamate-induced spinal cord injury
… of glutamate toxicity involving activation of interleukin-1â (IL-1â). To assess the effects of glutamate on IL-1â and its natural blocking agent interleukin-1 receptor antagonist (IL-1ra), ELISA assays were used to measure the responses of endogenous IL-1â and IL-1ra to glutamate administered …
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Interleukin 1-beta bei der HIV-1 Infektion des Zentralen Nervensystems
… freigesetzt werden. Das Cytokin Interleukin-1 wird als einer dieser Faktoren in Betracht gezogen. Einige Studien zeigten den vermehrten Nachweis von Interleukin-1 in HIV-1 infizierten Zellkulturreihen sowie in Hirngewebe von HIV-1 infizierten Personen. Das Ziel dieser Studie ist …
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Die Hemmung der Bildung des Interleukin-1-Rezeptorkomplexes als redoxregulierter antiinflammatorischer Mechanismus
Das proinflammatorische Zytokin Interleukin-1 (IL-1) spielt eine zentrale Rolle bei Entzündungen und Infektionen. Die zellulären Antworten von IL-1 werden über den IL-1-Rezeptor Typ I (IL-1RI) vermittelt. Adapterproteine und die IL-1RI-assoziierte Kinase IRAK werden nach Ligandenbindung an den …
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An Investigation into the Effects of Macrophage Polarisation on Interleukin-1 Expression
… chronic inflammation and adaptive immunity - interleukin (IL)-1α and IL-1β. Although the role of M1 macrophages as drivers of inflammation has been extensively studied, unravelling the function of M2s in inflammation still requires further investigation. The work presented in this thesis …
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Novel Proteases That Regulate Interleukin-1 Alpha Activity During Inflammation And Senescence
Interleukin-1 alpha (IL-1a) is a powerful inflammatory cytokine that modulates both innate and adaptive immunity. As such, IL-1a is implicated in the development of multiple inflammatory and autoimmune diseases including atherosclerosis, arthritis and cancer. Therefore, understanding the mechanisms …
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Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
… cues however, I found that signaling through interleukin (IL)-1 receptor family is required for effector cytokine production by memory CD4 T cells. Mechanistically, IL-1R signaling provides post-transcriptional stability to T cell cytokine transcripts thereby enabling productive secretion of …
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Interleukin-1 (IL-1) as a potential contributor to the pathophysiology of Alzheimer's Disease
<p>Elevations of the pro-inflammatory cytokine interleukin-1 (IL-1) have been reported as part of the inflammatory response to injury and neurodegenerative disorders. The observation of increased IL-1 levels in the brains of patients with Alzheimer's disease (AD) triggered over two decades of …
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Tumor necrosis factor-alpha- and interleukin-1-induced cellular responses: coupling proteomic and genomic information
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review
… response impacts disease progression. Interleukin-1 (IL-1), a group of molecules known as pro-inflammatory cytokines, has emerged as a critical factor in periodontitis development. The two main forms, IL-1α and IL-1β, contribute to inflammation, tissue breakdown, and bone loss. Research …
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Neuroinflammation and comorbid depression: a role for interleukin-1 beta converting enzyme and indoleamine 2,3-dioxygenase
… leads to production of inflammatory mediators. Interleukin-1 beta (IL-1β) is a proinflammatory cytokine that elicits physiological and behavioral disturbances associated with both neuroinflammatory degenerative diseases and mood disorders. IL-1β requires enzymatic maturation by interleukin-1 …
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Interleukin-1 receptor antagonist delivery through adenoviral mediated gene transfer as a treatment for equine joint disease
The interleukin-1 (IL-1) system is a small group of cytokines composed of two agonist proteins and a receptor antagonist (IL-1Ra). The action of the IL-1 system is mediated through binding of these ligands to the IL-1 receptors. Binding of the IL-1Ra protein to IL-1 receptors has not been …
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Effects of sodium hyaluronate and triamcinolone acetonide on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1
… chondrocyte proteoglycan catabolism caused by interleukin-1 (IL-1) administration. Chondrocytes were collected from fetlock joints of ten horses euthanized for reasons unrelated to joint disease. Chondrocyte pellets were treated with media (negative control); media containing IL-1 only …
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