Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Interleukin 8 (IL-8)"”.
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Understanding the role of interleukin-8 (IL-8) in canine osteosarcoma metastasis
The student, Matthew Dowling, accepted the attached license on 2018-06-20 at 22:06.
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Immunomodulatory effects of lactic acid bacteria on human intestinal epithelial cells and macrophages in the context of a pro-inflammatory challenge
… and may vary with growth phase and medium. The ability of different lactobacilli strains (Lactobacillus helveticus R0052, L. rhamnosus R0011, L. rhamnosus GG) at different growth phases to modulate macrophage and intestinal epithelial cell cytokine production following a pro-inflammatory challenge …
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Intestinal Inflammatory Responses to the Indigenous Microbiota
… evaluated in HT-29 cells associated with Lactobacillus plantarum 299v in the presence or absence of tumor necrosis factor-alpha (TNF-alpha). Co-culture of TNF-alpha-stimulated HT-29 cells with L. plantarum 299v increased interleukin-8. (IL-8) mRNA expression above levels observed for cells treated …
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Polyunsaturated fatty acids and immune cell functions
… decrease TGF-ß1 production. GLA-rich borage oil supplementation resulted in significantly decreased ex vivo monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1a (MIP-1a) and interleukin-8 (IL-8) production from PHA-or LPS-stimulated PBMC compared with baseline. It …
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Role of interleukin-8 monomer-dimer equilibrium and glycosaminoglycan interactions in neutrophil recruitment
… (GAG) for recruiting target cells. Interleukin-8 (IL-8) is a proinflammatory chemokine, recruits neutrophils as a host response to infection and tissue injury.. An imbalance in the recruitment process has been attributed to a variety of autoimmune and inflammatory diseases. Knowledge …
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Oxidative Modifications of Apolipoprotein(a): Implications for Proinflammatory and Prothrombotic Roles of Lipoprotein(a) in the Vasculature
… the zymogen plasminogen and possesses several similar structural features. A key feature shared between these proteins is the presence of multiple repeats of a kringle domain, which possesses the ability to bind to exposed lysine residues with high affinity. Apo(a) contains several copies of a …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… impairments that directly affect their daily functioning, but are not effectively treated by current antipsychotics. Maternal immune activation (MIA) during pregnancy, which can be triggered by a variety of infectious agents, has been associated with the development of schizophrenia in …
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Functional genomics of motile commensal intestinal bacteria
Flagella confer upon bacteria the ability to move and are therefore organelles of significant bacteriological importance. The innate immune system has evolved to recognise flagellin, (the major protein component of the bacterial flagellar filament). Flagellate microbes can potentially stimulate the …
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Die Bedeutung leukozytärer Subpopulationen für die Arteriogenese im Kaninchenhinterlauf
… jedoch nicht nur auf Monozyten, und die Beteiligung anderer Leukozytensubpopulationen mit bekannter Bedeutung für das Kapillarwachstum (Angiogenese) in der Arteriogenese ist weitgehend unklar. In dieser Studie untersuchten wir den Einfluss von Granulozyten- und Lymphozytenchemoattraktion und …
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Local Inflammatory Responses in Pseudomyxoma Peritonei
… from 10 PMP specimens were immunostained for interleukin 6 (IL-6), interleukin 8 (IL-8), interferon inducible protein 10 (IP-10) and monocyte chemotactic protein 1 (MCP-1). Effects of IL-6 and IL-8 on cell growth were determined using recombinant human cytokines and the human mucinous …
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Psychoneuroimmunology and Chronic Pain
… and psychological components of chronic pain still warrant identification and exploration. Using central inflammation as a paramount factor in the creation and maintenance of chronic pain, this study aimed to investigate and describe the physical and psychological aspects of chronic pain …
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Roles of the P2X7 receptor in C6 astroglioma: in vitro and in vivo studies
… monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) and the angiogenic factor vascular endothelial growth factor (VEGF) suggesting the P2X7R in C6 cells is involved in mediating inflammation in tumors. In addition, BzATP treatment was found to enhance wound-induced cell …
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Epidermal Reactions to Injury with Implications for Innate Immunity
… of our primary interfaces towards the external milieu. Following injury, the physical barrier function of the skin is destroyed and the epidermis is left vulnerable to microbial invasion. Inducible innate immune response mechanisms exist to keep the wound site free from infection, thus allowing …
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Untersuchungen über die Interaktion von Meningokokken mit Zellen der Blut-Hirn-Schranke
… Daher wurde in der vorliegenden Studie mit Hilfe eines Zellkulturmodells die Freisetzung von Tumornekrosefaktor alpha (TNF-a), Interleukin-1b (IL-1b), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Monocyten-attrahierendem Protein-1 (MCP-1) und transformierendem Wachstumsfaktor beta (TGF-b) …
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Investigation of the functions of Matrix Metalloproteinase-8 (MMP-8) in Mammary Carcinoma Cells
… the UK today, with incidence rates rising steadily. Prognosis is improving but patients with metastatic disease only have a 15% chance of surviving 5 years beyond prognosis. Therefore, factors influencing the metastatic spread of breast cancer require better understanding. The matrix …
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Characterizing induced gene expression in Shigella flexneri following bile salt exposure
The Shigella species cause millions of cases of watery or bloody diarrhea each year in developing countries, with children under the age of five years most vulnerable to infection. Emerging strains of multidrug resistant Shigella emphasize the need for a comprehensive and cost-efficient vaccine; …
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INVESTIGATION OF ACUTE STRESS IMPACT ON NURSERY PIG GASTROINTESTINAL FUNCTION AND ABILITY OF BIOACTIVE COMPONENTS OF GARLIC TO MITIGATE STRESS-INDUCED PHYSIOLOGICAL CHANGES
… performance, gastrointestinal function, and ability of garlic-derived diallyl disulfide (DADS) and diallyl trisulfide (DATS) to mitigate deprivation-induced effects. For the first experiment, the effects of a 24-h post-weaning feed, water, or feed + water deprivation event on nursery pig growth …
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Synergistic Effects Of Garcinol And Gemcitabine In Enhancing Therapeutic Efficacy In Pancreatic Adenocarcinoma Cells And Its Effect On Microrna Profile
… CELLS AND ITS EFFECT ON MICRORNA PROFILE</p> <p>By</p> <p>MANSI PARASRAMKA</p> <p>ADVISOR: DR. SMITI V. GUPTA</p> <p>MAJOR: NUTRITION AND FOOD SCIENCE</p> <p>DEGREE: DOCTOR OF PHILOSPHY</p> <p>Human Pancreatic Cancer (PaCa) is one of the most hostile and fourth leading cause of cancer …
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The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
… rapid growth and proliferation of tumor cells will be limited at a stage when they encounter inadequate levels of oxygen and nutrient supply within the poorly vascularized tumor mass. These severe conditions negatively affect the proper folding of nascent proteins in the endoplasmic reticulum …
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Characterisation of the role of Fas in intestinal inflammation and cancer
… is poorly understood in the intestine. Whilst Fas is best studies in terms of its function in apoptosis, recent studies suggest that Fas ligation may mediate additional, non-apoptotic functions such as inflammation. Toll like Receptors (TLRs) play an important role in mediating …
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