Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Interleukin 5"”.
-
EOSINOPHILIC INFLAMMATION IN NASAL POLYPOSIS: REGULATION OF INTERLEUKIN 5 AND INTERLEUKIN 5 RECEPTOR α ISOFORMS
… pathogenesis of NP. Especially the regulation of interleukin-5 (IL-5) and the interleukin-5 receptor α (Rα) isoforms were studied with emphasis on future therapeutic strategies in NP. Characterisation of NP suggests a central deposition of plasma proteins (albumin), regulated by the subepithelial, …
-
Structural and functional studies of the Interleukin-5 receptor system
… successfully adopted in our group on example of Interleukin 4. To precisely localize minimal structural epitope it is essential to have structure of the ligand in its bound form and especially informative would be structure of complex of the ligand and its specific receptor alpha chain. For this …
-
Untersuchung der Interleukin-5-Rezeptor-Expression und der Aktivierung humaner eosinophiler Granulozyten
… mögliche therapeutische Intervention direkt am Interleukin-5-Rezeptor auf Eosinophilen zu denken.
-
Die Interaktion der Transkriptionsfaktoren NF-ATc und GATA-3 in T-Helfer-Zellen
Interleukin-5 ist ein Th2-Cytokin, das eosinophile Granulozyten aktiviert und B-Zellen zur Produktion von IgE stimuliert. Bei der Entstehung von allergischen (wie z.B. Asthma) und atopischen Reaktionen spielt die erhöhte Ausschüttung von IL-5 eine wichtige Rolle. Der Interleukin-5-Promoter weist …
-
The role of autophagy in allergic inflammation: a new target for severe asthma
I.INTRODUCTION 1 II.MATERIALS AND METHODS 4 1. Mice 4 2. EthicsStatement 4 3. Sensitization and challenge 4 4. Treatment protocols 5 5. Airway resistance measurements 6 6. Bronchoalveolar lavage and lunghistology 6 7. Cytokine levels in lung BALfluid 7 8. The measurement ofLC3expression 8 9. …
-
Eosinophilic Asthma Response to Therapy: 129Xe Magnetic Resonance Imaging and Computed Tomography
Novel biologic therapies, such as anti-interleukin-5 receptor α (anti-IL-5Rα) or benralizumab, have been developed to treat patients with severe eosinophilic asthma who experience frequent exacerbations, poor quality of life and increased risk of mortality. Whether this therapy results in disease …
-
Nasal Associated Lymphoid Tissue in health, infection and autoimmunity
… post- treatment samples to assess the impact of interleukin-5 blockade treatment on disease-associated signals and cell types in EGPA.