Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Interleukin 24"”.
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The Molecular Mechanisms Underlying the Cancer Killing Effect of Interleukin-24
<p>Interleukin-24 (IL-24) is an immunomodulatory cytokine that also displays specific anti-tumor effects across many cancer cell types. The tumor suppressor activities of IL-24 include inhibition of angiogenesis, metastasis, toxic autophagy, cancer-specific apoptosis, and sensitization to …
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Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
… This gene encodes for the cytokine MDA-7/IL-24 that has the ability to specifically target transformed cells. Assays performed with this adenovirus resulted in an increased percentage of cell death in renal cancer cells when compared to infection with Ad.5/3-cmv empty vector. Further assays …
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Chemical genetic manipulation of interferon regulatory factor 1 (IRF-1) using synthetic biology
… standard interferon regulatory genes such as, interleukin-24 (IL-24) and interferon regulatory factor-2 binding protein-2 (IRF2BP2) and the up-regulation of standard apoptotic genes such as, early growth response-1 (EGR-1) and prostate transmembrane protein, androgen induced-1 (PMEPA1) …
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Splice Factor SFRS6: Regulation by p53 and Effect on IL-24 Splicing
… to DNA damage and apoptosis, one of which is IL-24. Silencing of SFRS6 results in an increase in a splice variant that lacks exons 2 and 3, while overexpression results in an overall shift away from the larger splice isoforms. In examining the splicing of IL-24, we identified numerous splice …