Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Interleukin 17"”.
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
Intrahepatic cell-derived IL-17 and IL-22 are important for T cell priming and hepatoprotection in viral hepatitis, respectively; however, the source and regulation of these cytokines in the liver microenvironment are not well defined. Here, we present evidence for a significant expansion of IL-17- …
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ESTROGEN, VASCULAR INFLAMMATION, AND INTERLEUKIN-17 IN RELATION TO ATHEROSCLEROSIS IN A FEMALE NONHUMAN PRIMATE MODEL
The role of T helper 17 (Th17) cells and interleukin-17A (IL-17A), a signature pro-inflammatory cytokine for Th17, in atherosclerosis is unknown. Postmenopausal estrogen therapy (ET) mediates atheroprotection in part through anti-inflammatory effects; however, the effects of ET on Th17 cells and …
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Neurochemical drivers of visceral pain: insights into the roles of interleukin-17 and the proton-sensing G protein-coupled receptor GPR68
… that drive pain in the gut, with a focus on interleukin 17 (IL-17) and the proton-sensing G protein-coupled receptor (GPCR) GPR68. In the first part of my research, I identified IL-17 as a pro-nociceptive cytokine. This was based on transcriptomic data showing elevated IL17A expression in …
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HIV prophylaxis: an essential role for T cells and adjuvants in recombinant mucosal Lactobacillus acidophilus vaccines
… strains along with strains expressing adjuvants (interleukin-1β or flagellin) to improve immunogenicity against the HIV MPER. We compared the adjuvant strains to the MPER-only strain by oral administration in BALB/c mice to observe these improvements, and in CD40L-/- mice to observe if T cell help …
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Novel Immunometabolic Therapies and Prognostic Markers for Lymphedema
… lymphedema tissues identified that increased interleukin 17 (IL-17) signaling and decreased peroxisome proliferator-activated receptor (PPAR) signaling occurred early in lymphedema and were sustained chronically. These gene expression changes co-occurred with fibrosis, which began to develop …
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Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract
… mirror the effector functions of Th1, Th2 and Th17 cells and share the same transcription factors and cytokine profiles. This project focussed on type 3 ILCs (ILC3s) found primarily at mucosal surfaces with roles in immune defence, tolerance and homeostasis. The key aims were to identify ILC3s …
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Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation
Interleukin-17 (IL-17) plays a major role in inflammation by regulating the induction of various proinflammatory genes, which aid in the recruitment and activation of neutrophils. Although IL-17 is considered to be protective in infection, overproduction of IL-17 in conditions like autoimmune …
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Alterations in endometrial immune cell populations affect endometrial cell functions
… (Treg) and pro-inflammatory T-helper-17 (Th17) lymphocytes in the eutopic endometrium of patients with the primary complaint of infertility; 2) explore the involvement of interleukin-17 (IL-17) in the promotion of a pro-inflammatory environment and the consequences of this altered …
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VIRAL MODULATION OF MHC CLASS II-MEDIATED ANTIGEN PRESENTATION
… was reduced, while a novel inflammatory cytokine Interleukin-17 (IL-17) production was enhanced in asthmatic VV-infected mice. In health mice, repeated VV infections lead to enhanced CD8 T cell production of Interferon-γ (IFN-γ) and IL-17. Finally, antibodies to a viral protein H3 were generated …
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Astrocytes modulate microglial phenotype and dendritic cell-like properties
… molecules in bone marrow-derived DCs. Neither interleukin-10, transforming growth factor-beta, nor prostaglandin E2 are responsible for the inhibition. Rather, contact with the astrocytic environment is responsible for the suppressive qualities. Microglia cultured in the presence of astrocytes …
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Role of IL-17A and Acaid in the Maintenance of Corneal Immune Privilege
… role of a newly identified T cell subset, the Th17 CD4+ T cell lineage and its production of the cytokine, IL-17A in modulating corneal immune privilege and the outcome of keratoplasty. Previously, the Th17 T cell subset and its pro-inflammatory cytokine, IL-17A had been associated with the …
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Expression of Th17 and related cytokines according to clinical activity of Behcet's disease
… other T cell populations were discovered, and IL(Interleukin)-17 producing Th17 cells were recognized as novel group of T cells which play a major role in autoimmunity. A recent study has shown elevated production of IL-17, IL-23, and IFN (Interferon)-γ by peripheral blood mononuclear cells …
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Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition
… EAE, we tested the effects of γSI on TH1 and TH17 differentiation. Culture with γSI reduced the expression of IFNγ and IL-17 without altering T cell activation or proliferation. The expression of Tbet and RORgt was strongly reduced by γSI while the number of FoxP3-expressing T cells increased. …
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Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
… to various other immune cells and tissues. IL-17-producing T helper: TH17) cells are a CD4+ T cell subset that coordinates inflammatory responses in host defense but are pathogenic in autoimmunity. To study the role of Batf in T cells, we generated Batf deficient mice by gene targeting. Batf …
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The effects of equine plasma transfusion on markers of inflammation in healthy neonatal foals
… concentration (interferon-gamma [IFN-γ], interleukin- 1β [IL-1 β], tumor necrosis factor-α [TNF- α], interleukin-6 [IL-6], interleukin-10 [IL-10] and interleukin-8 [IL-8], interleukin-4 [IL-4], interleukin-17 [IL-17]), and 3) changes in acute phase protein (fibrinogen [FIB] and serum …
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The ontogeny and function of intestinal dendritic cells
… the generation and maintenance of the intestinal interleukin 17 (IL-17)-secreting helper T (Th17) cell compartment. Mechanistically, in vitro and in vivo experiments suggest that the ability of CD103+CD11b+ intestinal cDCs to induce Th17 differentiation is linked to their capacity to produce IL-6. …
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Inhibitory potential of anthocyanins and anthocyanin-rich extracts on colorectal cancer progression through apoptosis, angiogenesis, and immune response effects
… the AOM/DSS control had 12.8 ± 0.9 (p<0.05). Interleukin-6 protein expression was downregulated in colon mucosa (-44.5%), plasma (-72.6%) and gene expression was reduced in colon polyp tissue (fold change: -4.0) in the black lentil group compared to the AOM/DSS control. Although the D3G group …
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Major traumatic injury : serum cytokine biomarkers as predictors of poor clinical outcome
… other immune cells using secreted cytokines. Interleukins are a large class of cytokines, which are involved in systemic inflammation and immune system modulation by stimulating humoral or cell-mediated immune responses. They play an important role in fighting infection and diseases. …