Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Interleukin 13"”.
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Genetische Untersuchungen zum Interleukin-13 Rezeptor alpha2 – einem Kandidatengen der Atopieentstehung
Der Interleukin-4 / Interleukin-13 Signalweg nimmt in der Pathogenese der Atopie eine zentrale Stellung ein. Sowohl für die Zytokine, als auch für Rezeptorketten und Signalmoleküle konnte eine Beteiligung am atopischen Geschehen nachgewiesen werden. Im Rahmen dieser Arbeit wurde versucht, mit Hilfe …
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LOCO-REGIONALLY TARGETING INTERLEUKIN-13 RECEPTOR ALPHA-2 AND MAXIMIZING THERAPEUTIC ACCESS TO GLIOBLASTOMAS USING BIOMARKER DIRECTED ALPHA PARTICLES
… for loco-regionally delivering therapies. Interleukin-13 receptor alpha-2 (IL13RA2) is one such GBM restricted biomarker which was previously discovered to be highly upregulated in about 75% of GBM samples and found to be an effective target for delivering tumor-specific cytotoxic …
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SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME
… an intensive search for efficient new therapies. Interleukin 13 receptor alpha 2 (IL-13Rα2) is an internalized, plasma membrane receptor for IL-13. IL-13Rα2 is over-expressed in around 75 percent of GBM patients. One of our goals is to develop specific therapeutic delivery vehicles and …
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Reprogramming the immune environment in breast cancer via dendritic cells.
… development of inflammatory Th2 cells producing interleukin 13 and tumor necrosis factor in vitro. Antibodies neutralizing TSLP or OX40L inhibit breast tumor growth and interleukin 13 production in a humanized mouse model of breast cancer. Thus, breast cancer cell-derived TSLP, by inducing OX40L …
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Imaging innate immune cell behaviour in lymphoid organs
… demonstrated that ILC2s were the early source of interleukin-13. ILC2s were in T cell areas of LNs and Peyer’s patches, and increased in cell number, size and speed of movement following inflammatory challenge, suggesting a potential role in cytokine distribution. Within small bowel wall ILC2s …
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In Vivo Studies on the Transcriptional and Posttranslational Regulation of the CCAAT/Enhancer Binding Protein Beta
… are macrophage scavenger receptor 1 (Msr1) and interleukin 13 receptor alpha1 (IL13a1). We also show that the well-known regulation of the arginase 1 gene by C/EBPbeta is dependent on the ability of CREB to upregulate C/EBPbeta. FACS analyses on our bone marrow-derived macrophage population, …
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Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… mechanisms (operating via cytokines such as Interleukin-13 (IL-13)) are downregulated. IL-13 has been shown to protect β-cell viability via STAT6 signalling, and preliminary data suggested that Signal Regulatory Protein-α (SIRPα) also plays a vital part in this protective effect. However, the …
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The Immunology of Adeno-Associated Virus Serotype 2
… elicited interferon-gamma (IFN-γ) (10 donors), interleukin-10 (IL-10) (8 donors) and interleukin-13 (IL-13) (4 donors). Using a series of overlapping peptides derived from the sequence of the VP1 viral capsid protein, a total of 59 candidate T-cell epitopes were identified. HLA characterisation …
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Investigating mitochondria alterations in esophageal pathologies
… patients and mice with EoE-like inflammation. Interleukin-13 (IL-13), a key EoE-associated cytokine, was found to induce mitochondrial accumulation in esophageal keratinocytes in vitro and this response was associated with increased expression of mediators of mitochondrial biogenesis, fusion, …
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Fullerene Based Nanomaterials for Biomedical Applications
… functionalized metallofullerenes conjugated with interleukin-13 peptide exhibits enhanced targeting of U-251 glioblastoma multiforme (GBM) cell lines and can be effectively delivered intravenously in an orthotopic GBM mouse model. Chapter 3 shows, with the specific targeting moiety, the …
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Charakterisierung der allergischen Immunantwort : Vergleich der in-vitro Zytokinproduktion isolierter mononukleärer Zellen und der in-vitro Zytokinproduktion aus Vollblutproben bei Neonaten und Erwachsenen
… Konzentrationen der Zytokine IFN-g, IL-10 und IL-13 mittels ELISA quantifiziert. <br>Bei den Neonaten wurden sowohl nach PHA -, als auch BLG-Stimulation signifikant niedrigere IFN-g (MC: PHA 588 pg/ml; BLG 819 pg/ml) - und IL-10-Werte (MC: PHA 485,7 pg/ml; BLG 163,4 pg/ml) gefunden, als bei den …
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Untersuchung zur Phagozytose eosinophiler Granulozyten durch Makrophagen unter Zytokineinfluss
… mit beiden Zytokinen. <br>Das TH2-Zytokin IL-13 spielt eine bedeutende Rolle in der Entstehung und Aufrechterhaltung der Eosinophilie. Es konnte gezeigt werden, dass IL-13 in der Lage ist, die Phagozytosekapzität für eosinophile Granulozyten durch Makrophagen in vitro konzentrationsabhängig zu …
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Major traumatic injury : serum cytokine biomarkers as predictors of poor clinical outcome
… other immune cells using secreted cytokines. Interleukins are a large class of cytokines, which are involved in systemic inflammation and immune system modulation by stimulating humoral or cell-mediated immune responses. They play an important role in fighting infection and diseases. …