Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Interleukin 1-beta"”.
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Transport of interleukin 1[beta] in calf epiphyseal cartilage
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Roles of interleukin-1 beta in glutamate-induced spinal cord injury
… of glutamate toxicity involving activation of interleukin-1â (IL-1â). To assess the effects of glutamate on IL-1â and its natural blocking agent interleukin-1 receptor antagonist (IL-1ra), ELISA assays were used to measure the responses of endogenous IL-1â and IL-1ra to glutamate administered …
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Interleukin 1-beta bei der HIV-1 Infektion des Zentralen Nervensystems
… freigesetzt werden. Das Cytokin Interleukin-1 wird als einer dieser Faktoren in Betracht gezogen. Einige Studien zeigten den vermehrten Nachweis von Interleukin-1 in HIV-1 infizierten Zellkulturreihen sowie in Hirngewebe von HIV-1 infizierten Personen. Das Ziel dieser Studie ist …
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Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
… cues however, I found that signaling through interleukin (IL)-1 receptor family is required for effector cytokine production by memory CD4 T cells. Mechanistically, IL-1R signaling provides post-transcriptional stability to T cell cytokine transcripts thereby enabling productive secretion of …
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Neuroinflammation and comorbid depression: a role for interleukin-1 beta converting enzyme and indoleamine 2,3-dioxygenase
… leads to production of inflammatory mediators. Interleukin-1 beta (IL-1β) is a proinflammatory cytokine that elicits physiological and behavioral disturbances associated with both neuroinflammatory degenerative diseases and mood disorders. IL-1β requires enzymatic maturation by interleukin-1 …
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Induction of Interleukin-1(beta) Converting Enzyme in the Brain and Its Role in Anorexia Induced by Centrally Administered Lipopolysaccharide
Precursor interleukin-1beta (IL-1beta) is cleaved by interleukin-1beta converting enzyme (ICE) to generate the biologically active form of IL-1beta. Interleukin-1beta synthesized in the brain is thought to be involved in the induction of sickness behavior by lipopolysaccharide (LPS). In the first …
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The effects of Tumour necrosis factor-alpha and Interleukin-1-beta on intracellular calcium handling and contractility in sheep ventricular myocytes
Proinflammatory cytokines such as TNF-α and IL-1β are implicated in the pathogenesis of inflammatory disease states such as sepsis. In sepsis, myocardial depression is a leading cause of death. To design novel therapeutic targets, it is essential that we understand how these cytokines mediate the …
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Association of the Interleukin-1 beta and Interleukin-1 Receptor Accessory Protein Gene Polymorphisms with Persistent Hepatitis B Virus Infection and Hepatocellular Carcinoma
… are probably related to host immune factors. Interleukin-1β (IL-1β) plays significant roles in inflammation and immune defense via IL-1 receptor accessory protein (IL-1RAcP). We investigated whether genetic polymorphisms of IL-1B and IL-1RAcP genes are associated with persistent HBV infection …
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Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
Background and aims: It has been reported that epithelial cells are involved in the process of inflammatory bowel disease (IBD) producing proinflammatory cytokines and chemokines. Glucocorticoids, being the most effective drugs for IBD patients, seem to have influence not only on the infiltrated …
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IL-1β Amplification of Nitric Oxide Production and Its Inhibitory Effects on Glucose Induced Early Growth Response-1 Expression in INS-1 Cells
… infiltrating white blood cells upon pancreatic beta cells is not fully understood. Early growth response gene-1 (Egr-1) expression is specifically and transiently up regulated in pancreatic beta cells in response to glucose. We hypothesized that interleukin-1 beta (IL-1▀) induction of nitric …
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Der Interleukin-1-Genkomplex in der Schizophrenie
… drei genetische Polymorphismen in Genen des Interleukin-1-Genkomplexes auf eine mögliche Assoziation mit Schizophrenie untersucht: die Gene, die für die proinflammatorischen Interleukine Interleukin-1 alpha und Interleukin-1 beta kodieren, sowie das Gen, welches für den antiinflammatorischen …
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Flavonoid Intake and Periodontal Healing Outcomes Following Sanative Therapy
… concentration levels (C-reactive protein, interleukin 1-beta, and interleukin-6) eight weeks after ST. The relationship between tea consumption or flavonoid intake and clinical outcomes following sanative therapy (ST) has not been investigated. Participants completed the 2014 Block food …
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Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
… were conducted. Hepatocyte growth factor (HGF), interleukin 1 beta (IL1Β), and insulin-like growth factor 2 (IGF2) were elucidated as genes that were significantly expressed in GD12 placenta. These genes are similar in that they are all connected to the Jak-Stat signaling pathway. These findings …
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Interaction Of Afferent Renal Nerve Activity And Il-1R Signaling In Hypertension
… under conditions of renal inflammation. Renal interleukin 1-beta (IL-1β) is elevated in many cases of hypertension, as well as the DOCA-salt model of hypertension, and its activity may be responsible for the elevation in afferent renal nerve activity and arterial pressure. IL-1R activation …
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Thalidomid und Rolipram führen zu funktionell relevanten Verbesserungen der Motorik nach traumatischen Rückenmarksverletzungen bei der Ratte
… tumour necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) play important roles during the early hours after injury. This period of secondary tissue degeneration presents an early therapeutic window of opportunity, during which intervention strategies directed at reducing the …
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Functions of The Homeobox Gene Dlx4 In Controlling Inflammatory Signaling and Metastasis of Epithelial Ovarian Cancer
… by activating the pro-inflammatory cytokine interleukin 1-beta (IL-1β) which in turn stimulates the nuclear factor kappa B (NF-κB) signaling pathway. This study provides insights into the mechanisms of peritoneal metastasis of EOC and raises the possibility that targeting inflammatory …
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