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Showing 1 to 20 of 306 for “"Interleukin - 6"”.
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Detection of glial interleukin-6 release: Development of a novel interleukin-6 Elisa
The development of an interleukin-6 (IL-6) enzyme-linked immunosorbent (ELISA) assay resulted in a detection range of 1 ng/m1 to 10 ng/mL IL-6. The limit of detection (LOD) for IL-6 was 0.25 ng/mL. Troubleshooting techniques were attempted including matrix effects, non-specific binding, and coating …
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Chemokinaktivität induziert durch Interleukin-6
Interleukin-6 belongs to the IL-6 type cytokine family. It signals through a receptor complex composed of the IL-6Ralpha and the signal-transducing subunit gp130. The activation of this receptor complex leads to the activation of the JAK/STAT pathway, the MAPK- and PI3K-caskade. IL-6 plays an …
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Kontinuierliche Überexpression von Interleukin-6 im Zentralnervensystem : lokale Applikation d. Designerzytokins Hyper-Interleukin-6 im adulten Organismus d. Ratte u. Auswirkungen v. exzitatorischen Neurotoxinen im Interleukin-6 transgenen Mausmodell
… Expression des Designerzytokins Hyper-Interleukin-6 (H-IL-6) im <br>Zentralnervensystem (ZNS) entwickelt. H-IL-6 besteht aus humanem Interleukin-6 (IL-6) verbunden mit löslichem IL-6 Rezeptor (sIL-6R). Erstmalig wurden hierfür makroverkapselte, H-IL-6 exprimierende Maus-Melanomzellen …
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Tissue specific genetic regulation of Interleukin 6
Interleukin 6 (IL6) is associated with arterial disease development, progression and surgical outcome. Raised levels of IL6 may play a causal role in disease development or may be the effect of pathology. An IL6 single nucleotide polymorphism (SNP) G- 174C has been identified and reported to …
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Regulation of Adrenal Steroidogenesis by Interleukin-6
Cortisol and dehydroepiandrosterone (DHEA) are steroids produced by the zona fasciculata (ZF) and reticularis (ZR), respectively, of the adrenal cortex. Both steroids are upregulated in response to adrenocorticotropic hormone (ACTH). Cortisol is a glucorticoid that is important in the regulation of …
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Contribution of Interleukin 6 Trans Signaling In Pulmonary Fibrosis
… no effective treatments available. Inhibition of interleukin 6 (IL-6) results in the attenuation of pulmonary fibrosis in mice. It is unclear whether this is due to blockade of classical<em> </em>signaling, mediated by membrane-bound IL-6 receptor alpha (mIL-6Rα), or trans signaling, mediated by …
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Methamphetamine, interleukin-6 and perineuronal nets in synaptic plasticity
… stress and lipid peroxidation mechanisms. Interleukin-6 (IL6) is a pleiotropic cytokine that is a mediator of immune and inflammatory processes. IL6 is known to mediate METH-induced neurotoxicity. We used mice models to test a combination of a clinical dose of METH and IL6 deficiency on …
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Die Rolle von Interleukin-6 beim Myelinabbau durch Makrophagen
In den letzten Jahren sind die Einflüsse von Zytokinen auf die Myelinbeseitigung immer mehr in den Focus wissenschaftlichen Interesses gerückt. Ziel der vorliegenden Arbeit ist die Klärung der Rolle des IL-6 beim Myelinabbau im peripheren Nerv. Die vorliegende Arbeit bietet Anhalt dafür, dass das …
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Die Rolle des Interleukin-6 bei der Wallerschen Degeneration
Die Rolle des Interleukin-6 bei der Wallerschen Degeneration. Untersucht wurde mit Hilfe von Interleukin-6 Knockout Mäusen die Rolle des Interleukin-6. Am Modell der Axotomie 4- und 6-Tage nach Axotomie des N. ischiadicus im Vergleich zu Wildtyp-Mäusen. Untersucht wurden immunhistochemisch die …
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Genetic Polymorphisms of Interleukin-6 in Systemic Lupus Erythematosus
… production of pathogenic autoantibodies. Interleukin-6 (IL-6) is a multifunctional cytokine that mediates inflammatory and immune responses, and IL-6 gene polymorphisms are known to play a part in chronic inflammatory and autoimmune disorders. We have identified single nucleotide …
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Interleukin-6 and its Contribution to Embryogenesis in Cattle
… investigated this by supplementing a cytokine, interleukin-6 (IL6), during in vitro embryo culture. My dissertation work expands upon those initial efforts by answering more detailed questions related to the biological role of IL6 during cattle embryogenesis. In the work presented herein, IL6 …
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Interleukin-6 Levels in Generalized and Localized Aggressive Periodontitis Patients
AbstractINTERLEUKIN-6 LEVELS IN GENERALIZED AND LOCALIZED AGGRESSIVE PERIODONTITIS PATIENTSBy Bindu Reddy, D.D.S.A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at the Virginia Commonwealth UniversityVirginia Commonwealth University, 2004Major …
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Interleukin-6, Depression, and Religious Coping in Older Seventh-day Adventists
… depressive symptoms and the inflammatory marker, interleukin-6 (IL-6), interact over time in 287 older adults (54% female, 63% White, Mage = 66, SDage = 10.9) from the Biopsychosocial Religion and Health Study and whether religious coping moderated this relationship. Depressive symptoms and IL-6 …
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