Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Interindividual variability"”.
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Metabolic and hormonal responses to altered carbohydrate availability and its effect on fatigue development
… and antecedent exercise exposure, on interindividual variability in metabolic and hormonal responses to dynamic, steady-state exercise. Further, this thesis examined the impact of altered blood glucose availability on fatigue development during prolonged exercise. In this regard, it …
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Pharmacogenomics and pharmacokinetics of antiretroviral drugs and their associations with metabolic complications in HIV-infected Black South Africans
… pharmacokinetics demonstrate considerable interindividual variability, which in part, may be explained by host genetic factors. Mitochondrial DNA (mtDNA) variation influences ART related metabolic complications. However, the associations between genetic polymorphisms and pharmacokinetics of …
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From individual behavior to collective structure
… presented the first detailed investigation of interindividual variability in the responsiveness of all workers involved in a collective behavior. My study has revealed that bumble bee workers evidence consistent responses to certain stimulus levels and differ in their response thresholds. Some …
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Cognitive, Clinical, and Biomarker Correlates of Insight in Obsessive–Compulsive Disorder: preliminary results of a cross-sectional study
… and sleep physiology as key elements of interindividual variability in OCD, supporting a multilevel framework linking cognition, psychopathology, and biological plasticity toward personalized phenotyping.
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Model-Informed Drug Development of Riluzole for Neuroprotection in Acute Spinal Cord Injury: Integrating Pharmacokinetics, Pharmacodynamics, and Clinical Outcomes for Precision Medicine
… complexity of SCI pathophysiology, considerable interindividual variability, and a relatively small patient population. Riluzole, a sodium channel blocker with established neuroprotective properties, was evaluated in the Riluzole in Spinal Cord Injury Study (RISCIS), a Phase II/III clinical trial …
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Investigating the Influence of Upper Limb Movements on Lower Limb Neuroplasticity in Humans
… and cortical excitability, although with notable interindividual variability. Specifically, rhythmic, symmetric UL movements significantly enhanced paretic leg strength and prolonged cortical silent period duration, indicating supraspinal engagement with therapeutic potential. Although spinal …
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Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures
… for the target transporter NKCC1. However, large interindividual variability and a paucity of physiological limited the accuracy of these simulations. In summary, augmentation strategies that focus on preventing bumetanide efflux from the brain via OAT3 may contribute to an improved outcome for …
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Pharmacokinetics of a high-concentration formulation of buprenorphine (Simbadol®) in male dogs
… 63% of the dosage absorption. Typical values (% interindividual variability) for the three compartment volumes were 900 (33), 2425 (not estimated) and 6360 (28) mL kg−1. The metabolic and two distribution clearances were 25.7 (21), 107.5 (74) and 5.7 (61) mL minute−1 kg−1. The absorption …
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
Genetic factors play a significant role in the interindividual variability of antidepressant response. This PhD thesis comprises three studies that investigate how genetic variations influence antidepressant treatment outcomes. The first study analyzed data from the STOP-PD II trial (N = 171), …
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
… with variations in cellular proliferation and interindividual variability in antioxidative and DNA repair capacities constituting important determinants of risk for environmentally-initiated oxidatively damaged DNA and its pathological consequences.
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Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
… heterogeneous disorder with substantial interindividual variability in antidepressant treatment response and tolerability. Genetic variation, particularly in pharmacokinetic genes such as CYP2C19 (drug metabolizing enzyme) and ABCB1 (encoding the drug-efflux transporter P-glycoprotein), …
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The Neural Correlates of the Age-Related Decrements in Selective Attention That Occur in Healthy Cognitive Aging: an FMRI Study of the Stroop Task
… and conclusive testimony of the widening interindividual variability in the functional patterns of the brain, and subsequently behaviour, in the elderly.
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Applying molecular methods to investigate potential anthropogenic impacts on ageing in a free-living bat species
… and inferred metabolic capacity. Despite high interindividual variability, there were no clear diAerences in overall microbial diversity and functional potential between sites and across ages. However, subtle shifts in the relative abundance of specific bacterial taxa and functional traits were …
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BRAIN ORGANOIDS AS MODELLING CONDUITS OF HUMAN NEURODIVERSITY: ADVANCED COMPUTATIONAL APPROACHES TO SINGLE CELL TRANSCRIPTOMICS
… leveraged this multi-genotype design to explore interindividual variability in neuronal migration, a process that is particularly relevant to cortical expansion and layering. Moreover, to tackle the need for more granular modelling capabilities, I mapped the SC transcriptional diversity of …
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Subcellular Fractionation Methods for the Quantification of Endogenous Protein in Human Liver Using Targeted Proteomics
… Our quantitative results and determination of interindividual variability will aid the future development of more accurate PBPK models for immunoglobulin G- or albumin- based biotherapeutics. Second, UPLC-MRM methods were developed for a panel of organelle marker proteins to accelerate the …
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DEVELOPMENT OF INDIVIDUAL VARIABILITY IN FUNCTIONAL CONNECTIVITY AND ITS ASSOCIATIONS WITH COGNITION AND PSYCHOPATHOLOGY IN YOUTH
… and mental health risk calculation. However, the interindividual FC variability during adolescence is still uncharacterized. Leveraging large population neuroimaging data, we depicted the spatial and temporal patterns of interindividual FC variability in youth. We observed the spatial distribution …
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Adjuncts to the Conventional 12-Lead ECG: Assessment of High-Frequency QRS Components and Additional Leads
… with normal individuals. There was substantial interindividual variability, however, which probably limits the clinical usefulness of this method. The study also showed that HF-QRS are not related to sex or age. In Study II, we investigated whether the amplitude of HF-QRS correlates to the left …
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Exploring metabolomics through NMR: from early life to aging
… its vulnerability to confounding, analytical variability, and overinterpretation. This thesis addresses this dual nature by exploring how metabolomic evidence can be made more robust and credible, not through isolated improvements, but by aligning study design, analytical workflow, statistical …
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Variability in the Affective Exercise Experience of Low-active Women: Exploring the Role of Cognitive Appraisal During Exercise
… a pilot investigation, demonstrated widespread interindividual variation in inactive female's affective responses during both high and low intensity exercise bouts. Study two was designed to investigate the affective responses of twenty low-active females throughout an incremental exercise test …
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Study of Erythroid Antioxidant Depletion in Childhood Obesity
… pinpointing the importance of addressing this interindividual variability as potential risk factors contributing to the susceptibility of developing obesity-associated complications at early ages. In summary, this Doctoral Thesis has demonstrated that childhood obesity accompanied by metabolic …
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