Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Interferons (IFNs)"”.
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
… receptor is a cytokine receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative effects, primarily through Jak/STAT signalling. The T-cell receptor is an antigenic receptor that recognises antigenically-derived …
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Characterizing the role of thymic interferon in T cell development and selection
Type I and III interferons (IFNs) are robustly induced during infections, where they protect cells against viral infection and activate immune cells. Curiously, both type I and type III IFNs were reported to be produced at low levels in the thymus in the absence of infection – the site of T cell …
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Sensing of Picornavirus Infections
… an immune response through the expression of interferons (IFNs) and cytokines. For RNA viruses, which replicate in the cytoplasm, the cytoplasmic RIG-I like receptors are responsible for this sensing. The contributions of these receptors to sensing viruses of the Picornaviridae family were …
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Innate Immune Sensing and Signaling of Cytosolic DNA
… responses including the production of type-I interferons (IFNs). Endogenous DNA that is inappropriately cleared can also accumulate in cytosol and drive pathological inflammation and autoimmune diseases such as systemic lupus erythematosus (SLE). It is well known that cytosolic DNA induces …
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The Interferon Stimulated Gene Product Lymphocyte Antigen 6 Complex, Locus E Promotes Entry of a Subset of Diverse RNA Viruses and Inhibits Infection by Coronaviruses
Interferons (IFNs) contribute to cell-intrinsic antiviral immunity by inducing hundreds of IFN-stimulated genes (ISG). In a screen to identify novel antiviral factors, the Schoggins lab unexpectedly uncovered a subset of genes that enhanced viral infection. Here, I describe my personal efforts to …
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The Role of Interleukin-10 Family Members in Inflammatory Skin Diseases. Understanding the mechanism of action of interferon lambda and interleukin-22 on human primary keratinocytes and dermal fibroblasts with a focus on healing responses in inflammatory skin diseases
… permanent scars depending on the subtype. Interferons (IFNs), including the skin specific IFNλ mainly activate STAT1, which results in inflammation in CLE and may play a significant role in scar formation in chronic discoid CLE. IL-22 activates STAT3 and it is emerging as a mediator with …
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On the function of the interferon-inducible p53 target gene TRIM22
… cell-cycle- progression and viral defence. Interferons (IFNs) are pleiotropic cytokines with antiviral, anti-proliferative, proapoptotic and immunmodulatory functions. Similar to TRIM22, many TRIM proteins are upregulated in response to IFNs, and many are involved in defence towards viruses, …
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Enhancement of Protective Immune Responses in Chickens against Marek's Disease Virus
… agonists induced the expression of type I and II interferons (IFNs) as well as interleukin (IL)-1β and delayed the manifestation of MD clinical signs. Finally, the effects of vaccination with HVT and infection with RB1B MDV were assessed on lung mononuclear cells, given the importance of the …
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Oleoylethanolamide and palmitoylethanolamide synergize with IFNβ to potentiate apoptosis and PD-L1 induction in SH-SY5Y neuroblastoma cells
… the efficacy of existing treatments. Type I interferons (IFNs), particularly IFNβ, are cytokines with well-characterized antiviral and anti-proliferative actions and documented capacity to trigger apoptosis in tumour cells, including NB. In this study, we investigated whether OEA and PEA …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early post viral infection, there is induction and secretion of IFN-β which alerts nearby cells and primes leukocytes for an immune response. A rapid response is necessary for effective control of virus …
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Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… NF-kB and IRF3, in the induction of type I interferons (IFNs) and IFN-stimulated genes (ISGs) that ultimately establish an antiviral state. These signaling pathways are central to host antiviral defense and thus become targets for viral interference. Hepatitis A virus (HAV), a hepatotropic …
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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
<p>The induction of Type I Interferons (IFNs) is a powerful and rapid innate defense mechanism against viral infection, and many viruses have developed elaborate strategies to overcome the antiviral effects of IFN, ensuring their survival and replication. Severe acute respiratory syndrome …
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Cytokine modulations by type I interferon suppression-negative and NF-κB activation-negative Porcine Reproductive and Respiratory Syndrome Virus
… suppresses innate immunity, namely, type I interferons (IFNs-α/β) during infection and predisposes infected hosts to secondary bacterial infections. PRRSV also activates NF-κB signaling such that the secondary infection may trigger enhanced expression of proinflammatory cytokines. This …
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Multiple Sclerosis: Studies of the Interferon system and search for infectious agents
… environmental contributions to the pathogenesis. Interferons (IFNs) are naturally occurring proteins known to have antiviral, antiproliferative and immunoregulatory effects. Treatment with IFN beta has a favourable effect in MS while IFN gamma was found to precipitate exacerbations. We have …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
… of tobacco smoke. Published data show the use of interferons (IFNs) in the treatment of lung tumours due to their potential in displaying antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. Type1 IFNs have been employed as treatments for many types of cancer, both for …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
… of tobacco smoke. Published data show the use of interferons (IFNs) in the treatment of lung tumours due to their potential in displaying antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. Type1 IFNs have been employed as treatments for many types of cancer, both for …
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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
… protect against viral infection through type I interferons (IFNs). Despite data demonstrating importance of mDCs and pDCs in protection against RSV, it has not been studied in an age appropriate model. Using a neonatal mouse model, we have shown that downregulation of IL-4 receptor alpha …
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Brain Endothelial Cells Orchestrate an Anti-Encephalitic State in the Central Nervous System in Response to Peripheral Viral Infection
… remain unclear. Previous research has identified interferons (IFNs), small antiviral cytokines, as critical to control WNV infection. However, most work examines the role of IFN in the periphery or in the CNS only post-neuroinvasion. We still do not fully understand how the CNS responds to viral …
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Characterizing novel molecular regulators of antiviral gene expression
… and initiation of inflammatory responses, type I interferons (IFNs) are particularly important, as they potently induce the production of hundreds of IFN-stimulated genes (ISGs), many of which have antiviral functions. The type I IFN response requires tight molecular coordination to achieve both …
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Regulation of type I interferons in murine dendritic cells
… of innate and adaptive immune responses. Type I interferons (IFNs), as important danger signals, activate cDCs through the canonical type I IFN receptor signaling. Type I IFNs are the first line of host defense against viral infection by up-regulating IFN-stimulated genes (ISGs). However, there …
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