Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Interferon-β"”.
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MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β
… Although it has been widely noted that interferon-beta; (IFN-beta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood. We describe here a novel …
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Human Neural Stem Cell-Derived Neuron/Astrocyte Co-Cultures as a Model System to Study Emerging Encephalitic Viruses
… possibly due to astrocytic responses to interferon. Additionally, neuron/astrocyte co-cultures responded to LACV infection with strong proinflammatory cytokines and chemokines. In contrast, NiV replicated in both neurons and astrocytes, inhibited inflammatory cytokine/chemokine …
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Wertigkeit von Magnetresonanzspektroskopie und Magnetisierungstransferbildgebung in Diagnose und Verlaufsbeurteilung der Multiplen Sklerose
… vorliegenden Arbeit wurde unter der Therapie mit Interferon β 1a das Verhalten von MTR und konventionellen MR-Parametern sowie klinischen Parametern über den Zeitraum von mindestens 2 Jahren im monatlichen Intervall untersucht. Die MTR innerhalb von Läsionen stieg im Beobachtungszeitraum bei allen …
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Functional Analysis of the Molluscum Contagiosum Virus MC160 Death Effector Domain-Containing Protein RxDL Motif
… responses such as apoptosis and activation of interferon (IFN). Presumably, MC159 and MC160 bind to host DED-containing proteins as a means to prevent the formation of innate immune signaling complexes. The RxDL motif is conserved among several host and viral DED-containing proteins and has …
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The role of the interaction of the influenza B virus NS1 protein with the cellular Brd2 protein
… terminal two thirds of the protein, suppresses interferon-β (IFN-β) synthesis in virus-infected cells by unknown mechanism(s). The induced IFN-β mediates innate immunity. To elucidate the mechanism by which the NS1B effector domain suppresses the production of IFN-β, we identified cellular …
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Amelioration of the chronic relapsing experimental allergic encephalomyelitis (CR-EAE) using thymoquinone
… as, if not more, therapeutically efficacious as interferon β and glatiramer acetate.
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A Study of Human Coronavirus NL63: Characterization of Virus Replication, Targeting of Papain-Like Protease 2 by Antivirals and Probing Virus Mediated Innate Immune Antagonism
… investigated HCoV-NL63 mediated antagonism of interferon-β (IFN-β) induction. I showed that HCoV-NL63 infection of bronchial epithelial cells results in a small, but measurable release of IFN-β by enzyme linked immunosorbent assay (ELISA). I confirmed that HCoV-NL63 PLP2 is an IFN-β antagonist, …
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The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
… to bind dsRNA and failed to initiate antiviral interferon-β and pro-inflammatory NF-κB responses. Using gene knockdown and gene editing in immortalized and patient derived cell lines, I demonstrated an essential role for MDA5 in restricting rhinovirus infection in human respiratory epithelium. …
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Development of novel imaging technology to study cell signalling
… The nanopipette was also used to locally deliver interferon β onto mouse embryonic fibroblasts, to trigger the interaction between the interferon alpha and the beta receptor subunit 1 and the interferon alpha and beta receptor subunit 2. Lastly, in order to improve the light sheet imaging …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… Tumor Necrosis Factor-α (TNF-α) and anti-viral interferon- β (IFN-β) cytokines are highly expressed in MCV lesions and surrounding tissue. Despite the expression of pro-inflammatory factors, MCV infections cause little inflammation. Not surprisingly, MCV encodes immunomodulatory proteins such as …
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Molecular Mechanisms of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
… significantly upregulated the mRNA expression of interferon-β and interferon stimulated genes (ISGs). The results from our studies suggest a critical role for PERK in regulating the host innate immune response to PRRSV infection. Only with a better understanding of the underlying molecular …
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Modulation of macrophage function and immune response by a helminth-derived cysteine protease
… receptor-domain-containing adaptor-inducing interferon-β (TRIF)-dependent signalling pathways. Furthermore, expression of IL-10 and co-stimulatory molecule CD86 was down-regulated in FhCL1-treated human monocyte-derived macrophages, and this was attributed to suppression of late endosomal …
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Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
… den suszeptiblen Wirtsspezies erklären könnte. Interferon-β (IFN-β) ist eine zentrale Komponente des angeborenen Immunantwort. Daher wurde die IFN-β-antagonistische Funktion des NSs-Proteins von RVFV Isolaten unterschiedlicher Herkunft (Säugetiere, Menschen und Insekten) nach Klonierung und …
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African swine fever virus CD2v protein induces β-interferon expression and apoptosis in swine peripheral blood mononuclear cells
Embargo set by: Seth Robbins for item 121229 Lift date: 2024-01-12T22:55:09Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system