Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Interferon system"”.
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Multiple Sclerosis: Studies of the Interferon system and search for infectious agents
… (MS) is a chronic disease of the central nervous system, characterized by focal inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. Interferons (IFNs) are naturally …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder characterized by inflammation in several organ systems. SLE patients have an impaired ability to clear dying cells which leads to the exposure of several nuclear antigens which might break self tolerance. Autoantibodies directed …
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Data-driven and Machine Learning approaches for exploration and inference of Biological Pathways in physiological and pathological states
… and broad applicability of pathways across systems biology, there is scope for improvement regarding their comprehensiveness and quality. Previous work has shown that they are incomplete and inconsistent. In support of this view, here I show that pathway databases are not yet sufficiently …
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Comparative Transmission and Pathogenesis of La Crosse Virus (LACV) Lineages and Evidence for LACV Circulation in Virginia Wildlife
… lineage I and II can overcome the host immune system through the interferon pathway, allowing viral replication. We hypothesize that lineage III cannot circumvent the interferon system as the other lineages can and, therefore, cannot replicate to cause clinical disease. Overall, although …
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Biochemical and structural characterization of radical SAM enzymes Elp3 and viperin
… in mammalian cells is the induction of the interferon system, which activates IFN-stimulated genes (ISGs) to inhibit various stages of viral replication. Viperin (for virus inhibitory protein, endoplasmic reticulum associated, interferon inducible) is one of the ISGs which has antiviral …
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Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
… den suszeptiblen Wirtsspezies erklären könnte. Interferon-β (IFN-β) ist eine zentrale Komponente des angeborenen Immunantwort. Daher wurde die IFN-β-antagonistische Funktion des NSs-Proteins von RVFV Isolaten unterschiedlicher Herkunft (Säugetiere, Menschen und Insekten) nach Klonierung und …