Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Interferon regulatory factor 4"”.
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Genetic alterations defining human primary melanoma and mechanisms of immune evasion
… genetic vulnerability mediated by Interferon Regulatory Factor 4 (IRF4). I then begin to experimentally validate and explore the biological pathway by which IRF4 may function in the context of melanoma. Checkpoint inhibitors have revolutionised melanoma care, yet only a minority of …
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… (CRBN), Ikaros (IKZF1), aiolos (IKZF3) and Interferon regulatory factor-4 (IRF4), a significant downregulation of protein levels was observed after treating the MM cell lines with sub-cytotoxic concentrations of ZnDDC (2-5 μM). After exposure to low concentration of ZnDDC, levels of both …
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Exploring the role of IRF4 in the sensitivity of mantle cell lymphoma cells to Bruton's Tyrosine Kinase inhibitors
Introduction and aim: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell lymphoma. Therapy using Bruton’s tyrosine kinase (BTK) inhibitors has improved clinical outcomes but primary and secondary resistance to BTK inhibitor (BTKi) therapy affects more than half of MCL patients. …