Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Interferon pathway"”.
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BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1
… and signals subsequent production of type-I interferon. The TLR3:interferon signaling cascades contains a kinase complex composed of two kinases and a scaffold protein, NAK-associated protein 1 (NAP1). The role of NAP1 in modulating kinase activation or regulation is unknown. A key inhibitory …
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EPIGENETIC MODIFICATIONS REGULATING LIVER HOMEOSTASIS AND TUMORIGENESIS
… with loss of all liver specific metabolic pathway. Furthermore, we observed how the absence of both the ARID1 proteins characterized a complete loss of H3K4me1 and H3K27Ac histone modifications on all the FoxA2 targets both on promoter and enhancers. Ultimately, cBAF complex is necessary to …
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Proviral Roles of Ebola virus VP35 Ubiquitination
… life cycle from antagonizing the host’s type I interferon pathway to acting as the polymerase co-factor. The mechanisms that regulate which function any given VP35 molecule engages remains unknown. Previously, we observed the host E3 ubiquitin ligase TRIM6 conjugates ubiquitin onto VP35 at …
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Comparative Transmission and Pathogenesis of La Crosse Virus (LACV) Lineages and Evidence for LACV Circulation in Virginia Wildlife
… can overcome the host immune system through the interferon pathway, allowing viral replication. We hypothesize that lineage III cannot circumvent the interferon system as the other lineages can and, therefore, cannot replicate to cause clinical disease. Overall, although lineage III can be …
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Effect of HIV infection and pregnancy on parameters of vaginal immunity
… in HIV sexual transmission. We focused on two pathways: The NF-KB inflammation pathway that has been implicated in susceptibility to HIV infection, and two interferon pathways that have been associated with antiviral immune defense. We hypothesized that pregnant women have increased …