Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Interferon antagonism"”.
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… defense in response to viral infections. Type I interferons (IFN-α/β) are the major components of the innate immune system, and in turn many viruses have evolved to modulate the host interferon responses. In the present study, the PEDV IFN antagonism was investigated. We found that IFN-β …
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Multifunctional Coronavirus Papain-Like Proteases as Targets for Antiviral Therapeutics and Vaccines
… enzyme with protease, deubiquitinase, interferon antagonism and deISGylating activities. Despite low sequence identity, this multifunctionality of PLPs seems to be conserved among many coronaviruses. I demonstrated protease and deubiquitinase activity of PLP2s from HCoV-OC43, HCoV-229E, …
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Investigations into the viral molecular determinants of lethality of Punta Toro virus (Bunyaviridae, phlebovirus) in the Syrian hamster.
… NSs gene encoded by the S segment is a type 1 interferon antagonist. Taken together, this evidence indicates a mechanism of pathogenesis whereby early innate immune suppression by the viral NSs gene/protein in infected cells leads to uncontrolled viral replication that ultimately results in …
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Influenza A Virus PB1-F2 Protein: its Role in Pathogenesis
… increased virus replication, decreased type I interferon response, increased infiltration of neutrophils and myeloperoxidase production in lungs resulting in acute respiratory distress syndrome (ARDS) in mice with characteristic clinical and pathological features of acute lung injury (ALI). …