Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Interferon Type I"”.
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The Role of Interferon Stimlated Genes in Resistance and Immunity to Hepatitis C Virus Infection
… The only approved treatment for HCV infection is interferon-alpha based therapy, resulting in viral clearance in approximately fifty percent of patients treated. Interferon therapy mimics endogenous type I interferon signaling, which plays a crucial role in the innate antiviral response through …
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Identification and Characterization of Interferon-Stimulated Regulators of Bacterial Infection
The type I interferon activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes as a model bacterial pathogen, I sought to identify the roles of …
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Using Genetic and Pathogeneses Studies to Develop Antiviral and BVDV Vaccine Targets
… immune response through interfering with host type I interferon defense mechanism. Using immunoprecipitation coupled with mass spectrophotometry BVDV 1373 Npro showed association with S100A9 protein that may play role in mechanisms of cells resistance to the virus through activating interferon …
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Regulation of the cGAS-STING Pathway: Non-Agonist Activation and Cellular Trafficking
… acutely activate cGAS-STING, leading to type I interferon (IFN) signaling. STING-mediated IFN signaling is dynamically regulated by STING trafficking from the ER to the Golgi then to the lysosome. Cofactors and cellular mechanisms that facilitate STING trafficking and signaling are …
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Interferon-Dependent Mechanisms of Disease Pathogenesis in Respiratory Syncytial Virus Infection
… to the canonical antiviral activity of interferon type I (IFN I) and at the same time its paradoxical disease-enhancing properties which have been suggested in recent studies of human infections or experimental animal models. We have also shown that an important component of RSV-mediated …
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Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
… of replication organelles, antagonism of interferon type I (IFN-I) responses, and NLRP3 inflammasome activation, a major factor of severe COVID-19. Here, I review the most recent published findings regarding the multiple roles of nsp6 in promoting SARS-CoV-2 replication and investigate …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
CD8+ T cells or cytotoxic T lymphocytes (CTLs) play a major role in our defense against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are …
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Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
Previous studies demonstrate that interferon alpha (IFN-α) promotes human T helper 1 memory development by positively regulating interleukin-2 (IL-2) expression, a hallmark cytokine of central memory CD4⁺ T cells. The present work seeks to delineate how signaling through the interferon alpha/beta …