Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Interferon Regulatory Factors"”.
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THE ROLE OF INTERFERON REGULATORY FACTORS IN REGULATING THE EXPRESSION OF NKG2D LIGANDS
The DNA damage response (DDR) is a cellular response to genotoxic stress that triggers cell cycle arrest and DNA repair mechanisms. It has been previously shown that NKG2D ligands are upregulated by the DDR in a p53-independent manner. We provide evidence in this study that the upregulation of …
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The Impact of Cutaneous Papillomavirus and Interferon Regulatory Factors on Interferon Expression in Canine and Human Keratinocytes.
North Carolina State University Theses Veterinary Medical Sciences.
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A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infections
… (BMDCs) in response to M. tuberculois infection. Interferon Regulatory Factors (IRFs) and NFkB (Nuclear Factor kappa B) appear to be the principal transcription factors involved in regulating the cellular responses in M. tuberculosis infected BMDCs. It has been found that IRFs can function …
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Investigating the regulation and enzymatic function of human ecsit in innate immune signalling.
… of pathogens by activating transcription factors such as NFκB and the interferon regulatory factors (IRF)s to induce pro-inflammatory cytokines and IFNs. Whilst many of the components of the TLR signal transduction pathways have been identified, a full understanding of these complex …
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Understanding the Myddosome Complex: An Exploration of How Homotypic Death Domain Interfaces Contribute to Overall Structure.
… activation of downstream transcription factors, such as IRFs (Interferon Regulatory Factors) and NFκB. The crystal structure of the Myddosome was published by Lin et al [1], by combining the Death Domains of MyD88, IRAK4 and IRAK2. The complex was shown to form a left-handed helical …
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Regulatory Mechanisms in Innate Immunity
… adaptor proteins, kinases, and transcription factors that elicit the production of effector cytokines. As an important transcription factor, IRF5 was known to be essential for the host cytokine production in response to various ligands and SNPs in IRF5 have been closely related to autoimmune …
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Immunological boosting and personalization of oncolytic virotherapies for cancer treatment
… it to express DNA-dependent activator of interferon-regulatory factors (DAI), a potent inducer of innate immune responses during virus infection. We showed that the DAI-virus induces expression of genes involved in immune responses, and treatments with the virus showed improved …
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Discovery of Unique Antiviral Pathways in a Bat Viral Reservoir, the Black Flying Fox
… use to control viral infections is the interferon response. Upon viral infection, cells produce interferon which inhibits viral infection through downstream effectors called interferon stimulated genes. I questioned whether bat interferon stimulated genes contained unique properties that …
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Dendritic Cells Suppress Pathogen-Induced Inflammasome Activation to Prime Naïve T Cells
… to prime both CD4 and CD8 T cells. Transcription factors IRF8 and IRF4, in cDC1s and cDC2s respectively, mediate this suppression of inflammasome activation by limiting the expression of inflammasome-associated genes. Additionally, overexpression of either of IRF4 or IRF8 is sufficient to inhibit …