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Showing 1 to 19 of 19 for “"Interferon Regulatory Factor-3"”.

  1. REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5

    TANG PENG2014

    … UNDERSTOOD. HERE, WE DISCOVERED TWO PROTEINS, INTERFERON REGULATORY FACTOR 3 (IRF3) AND MAPK PHOSPHATASE 5 (MKP5) PLAY IMPORTANT ROLES IN OBESITY-RELATED METABOLIC DISEASES. WE FOUND THAT IRF3 IS A NEGATIVE REGULATOR OF ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION THEREBY TO INHIBIT THE …

    nus Repository record

  2. Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction

    Couto, Geoffrey de2012

    … Recent data strongly support a role for key regulatory components within the toll-like receptor (TLR) family as potent modulators of cardiac remodeling post-MI. It has been demonstrated that targeted gene knockdown of TLR4, as well as downstream adaptor proteins and kinases, significantly …

    toronto-retro Repository record

  3. Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease

    Foy, Eileen2007

    … Our studies identified the NS3/4A protein as an interferon regulatory factor 3 (IRF-3) and NF-<small>K</small>B antagonist and further mapped this activity to the NS3/4A serine protease domain. HCV antagonism of IRF-3 and NF- <small>K</small>B prevents the expression of interferon (IFN) and …

    tdl Repository record

  4. Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease

    Foy, Eileen2010

    … Our studies identified the NS3/4A protein as an interferon regulatory factor 3 (IRF-3) and NF-<small>K</small>B antagonist and further mapped this activity to the NS3/4A serine protease domain. HCV antagonism of IRF-3 and NF- <small>K</small>B prevents the expression of interferon (IFN) and …

    utswmed Repository record

  5. The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection

    Menachery, Vineet2010

    The type I interferon: IFN) cascade is critical in control of herpes simplex virus type I: HSV-1) infection and relies on specific recognition molecules to rapidly signal viral infection via interferon regulatory factor-3: IRF-3) -dependent pathways. The absence of these recognition molecules or …

    wustl Repository record

  6. Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape

    Bossert, BirgitLudwig-Maximilians-Universität

    … induction of IFN by inhibiting the activation of interferon regulatory factor 3 (IRF-3). As a result, BRSV is able to block the establishment of a cellular antiviral state. The characterization of interactions between virus (NS proteins) and the host cell (IFN system) will have important …

    lmu-germany Repository record

  7. Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling

    Ling, Hsiang-Hsi, <p>0000-0002-1678-4845</p>2027

    … immune evasion. Fak ablates stimulator of interferon genes (Sting)-dependent type I interferon production when DTCs awaken from dormancy, thus preventing immune-mediated elimination. Fak may therefore represent the elusive arbiter of Sting’s role as both an anti- and pro-metastatic …

    uthsc Repository record

  8. Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance

    Melidosian, Bihui2020

    … we show that tumor anti-viral transcription factors alter the epigenome, which amplifies tumor type one interferon (IFN-I) signaling that mediates resistance. Across human and mouse tumors, elevated interferon (IFN) signaling in cancer cells is associated with distinct epigenetic features …

    penn Repository record

  9. Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)

    Gates-Tanzer, Lauren TaylorUniversity of Illinois at Urbana-Champaign2018

    … regulation and more recently, modulation of interferon responses. Interferon alpha (IFNa) and interferon beta (IFNb) are in the class of type I IFN and are critical as the first line of defense against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection …

    uiuc Repository record

  10. Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus

    Gottipati, Keerthi 1983-The University of Texas Medical Branch at Galveston2016

    … the host’s innate immune response by targeting interferon regulatory factor-3 (IRF3) for proteasomal degradation, and thus preventing the transcriptional activation of interferon-α/β genes. We determined the crystal structure of wild type Npro and that of a cleavage site mutant (Npro-C168A) to …

    utmb Repository record

  11. Understanding Host Antiviral Signaling Pathways

    Bhargava, Rashu2010

    … which lead to the activation of transcription factors like nuclear factor-kappa B (NF-kappa B), interferon regulatory factor 3 (IRF3) and interferon regulatory factor 7 (IRF7). These transcription factors regulate the synthesis of protective cytokines including type I interferons. The first …

    utswmed Repository record

  12. Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus

    Lester, Sandra Nicole2020

    <p>The induction of Type I Interferons (IFNs) is a powerful and rapid innate defense mechanism against viral infection, and many viruses have developed elaborate strategies to overcome the antiviral effects of IFN, ensuring their survival and replication. Severe acute respiratory syndrome …

    tenn-hsc Repository record

  13. Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling

    Clifford, EileenNational University of Ireland Maynooth2010

    … presence of the TLR3 ligand, Poly(I:C), targets interferon regulatory factor 3 (IRF3), a transcription factor essential for regulating type I interferon (IFN) expression. These findings also demonstrate that protective effects of R(+)WIN55,212-2 in EAE mice exist, as evidenced by reduced clinical …

    maynooth Repository record

  14. Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein

    Randall, CrystalUniversity of Illinois at Urbana-Champaign2013

    … that the pro-inflammatory Tumor Necrosis Factor-α (TNF-α) and anti-viral interferon- β (IFN-β) cytokines are highly expressed in MCV lesions and surrounding tissue. Despite the expression of pro-inflammatory factors, MCV infections cause little inflammation. Not surprisingly, MCV encodes …

    uiuc Repository record

  15. Key Role of Lys63-Linked Polyubiquitination in Viral Activation of IRF3

    Zeng, Wenwen2010

    … and MDA5 to activate downstream transcription factors IRF3 and NF-kB, which contribute to the induction of IFNb. Despite growing list of components revealed in RIG-I/MAVS/IRF3 pathway, molecular mechanism by which MAVS activates IRF3 upon viral infection has remained largely unclear. In current …

    utswmed Repository record

  16. Mechanisms of microbial-host interaction during asymptomatic bacteriuria

    Grönberg Hernandez, JennyDivision of Microbiology, Immunology and Glycobiology - MIG2013

    … immune markers. The genetic polymorphisms in the interferon regulatory factor 3 (IRF3) and Toll-like receptor 4 (TLR4) promoter had a significant impact on the magnitude of the host response during E. coli 83972 ABU, which consisted of mainly innate immune mediators. The transcriptional host …

    lund Repository record

  17. Single molecule investigation of antiviral signaling

    Doganay, SultanUniversity of Illinois at Urbana-Champaign2014

    … leads to transcriptional activation of type I interferon (IFN). Type I IFN induces a large set of genes called interferon-stimulated genes (ISGs) that coordinate a response to antagonize viral invasion. We utilized single-molecule fluorescence in situ hybridization (smFISH) to study viral and …

    uiuc Repository record

  18. Identification of a gap junction communication pathway critical in innate immunity

    Patel, Suraj JagdishMassachusetts Institute of Technology2010

    … activation patterns of two key transcription factors in inflammation and innate immunity: Nuclear factor-KappaB (NFKB) and Interferon regulatory factor 3 (IRF3). Stimulation of NFKB-GFP reporters resulted in a spatially homogeneous pattern of activation, found to be largely mediated by …

    mit Repository record

  19. Studies on the interaction between porcine reproductive and respiratory syndrome virus and its natural host cell

    Chen, Wei YuUniversity of Illinois at Urbana-Champaign2016

    … ability of PRRSV to modulate the production of interferon (IFN)a and tumor necrosis factor (TNF)a by affected AMΦ is implicated in the virus’s pathogenesis. In this regard, infection of porcine AMΦ with PRRSV reduced by >50% the amount of IFN-α otherwise produced following the cells’ exposure to …

    uiuc Repository record