Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Interferon Regulatory Factor 3 (IRF3)"”.
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Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction
… Recent data strongly support a role for key regulatory components within the toll-like receptor (TLR) family as potent modulators of cardiac remodeling post-MI. It has been demonstrated that targeted gene knockdown of TLR4, as well as downstream adaptor proteins and kinases, significantly …
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REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5
… UNDERSTOOD. HERE, WE DISCOVERED TWO PROTEINS, INTERFERON REGULATORY FACTOR 3 (IRF3) AND MAPK PHOSPHATASE 5 (MKP5) PLAY IMPORTANT ROLES IN OBESITY-RELATED METABOLIC DISEASES. WE FOUND THAT IRF3 IS A NEGATIVE REGULATOR OF ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION THEREBY TO INHIBIT THE …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… immune evasion. Fak ablates stimulator of interferon genes (Sting)-dependent type I interferon production when DTCs awaken from dormancy, thus preventing immune-mediated elimination. Fak may therefore represent the elusive arbiter of Sting’s role as both an anti- and pro-metastatic …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… we show that tumor anti-viral transcription factors alter the epigenome, which amplifies tumor type one interferon (IFN-I) signaling that mediates resistance. Across human and mouse tumors, elevated interferon (IFN) signaling in cancer cells is associated with distinct epigenetic features …
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
… regulation and more recently, modulation of interferon responses. Interferon alpha (IFNa) and interferon beta (IFNb) are in the class of type I IFN and are critical as the first line of defense against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection …
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Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus
… the host’s innate immune response by targeting interferon regulatory factor-3 (IRF3) for proteasomal degradation, and thus preventing the transcriptional activation of interferon-α/β genes. We determined the crystal structure of wild type Npro and that of a cleavage site mutant (Npro-C168A) to …
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Understanding Host Antiviral Signaling Pathways
… which lead to the activation of transcription factors like nuclear factor-kappa B (NF-kappa B), interferon regulatory factor 3 (IRF3) and interferon regulatory factor 7 (IRF7). These transcription factors regulate the synthesis of protective cytokines including type I interferons. The first …
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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
<p>The induction of Type I Interferons (IFNs) is a powerful and rapid innate defense mechanism against viral infection, and many viruses have developed elaborate strategies to overcome the antiviral effects of IFN, ensuring their survival and replication. Severe acute respiratory syndrome …
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Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling
… presence of the TLR3 ligand, Poly(I:C), targets interferon regulatory factor 3 (IRF3), a transcription factor essential for regulating type I interferon (IFN) expression. These findings also demonstrate that protective effects of R(+)WIN55,212-2 in EAE mice exist, as evidenced by reduced clinical …
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Mechanisms of microbial-host interaction during asymptomatic bacteriuria
… immune markers. The genetic polymorphisms in the interferon regulatory factor 3 (IRF3) and Toll-like receptor 4 (TLR4) promoter had a significant impact on the magnitude of the host response during E. coli 83972 ABU, which consisted of mainly innate immune mediators. The transcriptional host …
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Single molecule investigation of antiviral signaling
… leads to transcriptional activation of type I interferon (IFN). Type I IFN induces a large set of genes called interferon-stimulated genes (ISGs) that coordinate a response to antagonize viral invasion. We utilized single-molecule fluorescence in situ hybridization (smFISH) to study viral and …
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Identification of a gap junction communication pathway critical in innate immunity
… activation patterns of two key transcription factors in inflammation and innate immunity: Nuclear factor-KappaB (NFKB) and Interferon regulatory factor 3 (IRF3). Stimulation of NFKB-GFP reporters resulted in a spatially homogeneous pattern of activation, found to be largely mediated by …
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Studies on the interaction between porcine reproductive and respiratory syndrome virus and its natural host cell
… ability of PRRSV to modulate the production of interferon (IFN)a and tumor necrosis factor (TNF)a by affected AMΦ is implicated in the virus’s pathogenesis. In this regard, infection of porcine AMΦ with PRRSV reduced by >50% the amount of IFN-α otherwise produced following the cells’ exposure to …