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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 40 for “"Interferon Regulatory Factor"”.

  1. Interferon Regulatory Factor 8 (IRF8) Transcriptionally Regulates the Macrophage Response During Tumor Immunosurveillance

    Twum, DanielleState University of New York at Buffalo2019

    Ph.D.

    buffalo Repository record

  2. Chemical genetic manipulation of interferon regulatory factor 1 (IRF-1) using synthetic biology

    Al Samman, Khaldoon Mohammed A, Alsamman, KhaldoonThe University of Edinburgh2012

    Interferon regulatory factor 1 (IRF-1), the founding member of IRF family, is a nuclear transcription factor first described as a transcription factor that binds to the upstream region of interferon induced genes following viral infection. In addition, IRF-1 has been reported to be involved in cell …

    edinburgh Repository record

  3. REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5

    TANG PENG2014

    … UNDERSTOOD. HERE, WE DISCOVERED TWO PROTEINS, INTERFERON REGULATORY FACTOR 3 (IRF3) AND MAPK PHOSPHATASE 5 (MKP5) PLAY IMPORTANT ROLES IN OBESITY-RELATED METABOLIC DISEASES. WE FOUND THAT IRF3 IS A NEGATIVE REGULATOR OF ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION THEREBY TO INHIBIT THE …

    nus Repository record

  4. Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction

    Couto, Geoffrey de2012

    … Recent data strongly support a role for key regulatory components within the toll-like receptor (TLR) family as potent modulators of cardiac remodeling post-MI. It has been demonstrated that targeted gene knockdown of TLR4, as well as downstream adaptor proteins and kinases, significantly …

    toronto-retro Repository record

  5. Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease

    Foy, Eileen2007

    … Our studies identified the NS3/4A protein as an interferon regulatory factor 3 (IRF-3) and NF-<small>K</small>B antagonist and further mapped this activity to the NS3/4A serine protease domain. HCV antagonism of IRF-3 and NF- <small>K</small>B prevents the expression of interferon (IFN) and …

    tdl Repository record

  6. Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease

    Foy, Eileen2010

    … Our studies identified the NS3/4A protein as an interferon regulatory factor 3 (IRF-3) and NF-<small>K</small>B antagonist and further mapped this activity to the NS3/4A serine protease domain. HCV antagonism of IRF-3 and NF- <small>K</small>B prevents the expression of interferon (IFN) and …

    utswmed Repository record

  7. MANIPULATIONS OF MACROPHAGE ACTIVATION THROUGH TARGETED DELIVERY OF INTERFERON REGULATORY FACTOR GENES MEDIATED BY RECOMBINANT ADENOVIRUS-CONJUGATED ZYMOSAN

    Zhang, Mengmeng

    clemson Repository record

  8. The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection

    Menachery, Vineet2010

    The type I interferon: IFN) cascade is critical in control of herpes simplex virus type I: HSV-1) infection and relies on specific recognition molecules to rapidly signal viral infection via interferon regulatory factor-3: IRF-3) -dependent pathways. The absence of these recognition molecules or …

    wustl Repository record

  9. Transcriptional Regulation of NLRC4 Inflammasome by IRF8

    Lee, Ein2019

    … macrophages (BMDMs) is greatly dependent on interferon regulatory factor 8 (IRF8). NLRC4-mediated caspase-1 activation and subsequent production of the inflammasome-dependent cytokines IL-1β and IL-18 and cell death were impaired in IRF8-deficient cells. IRF8 mediated the transcription of …

    tenn-hsc Repository record

  10. Understanding Host Antiviral Signaling Pathways

    Bhargava, Rashu2010

    … which lead to the activation of transcription factors like nuclear factor-kappa B (NF-kappa B), interferon regulatory factor 3 (IRF3) and interferon regulatory factor 7 (IRF7). These transcription factors regulate the synthesis of protective cytokines including type I interferons. The first …

    utswmed Repository record

  11. Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape

    Bossert, BirgitLudwig-Maximilians-Universität

    … induction of IFN by inhibiting the activation of interferon regulatory factor 3 (IRF-3). As a result, BRSV is able to block the establishment of a cellular antiviral state. The characterization of interactions between virus (NS proteins) and the host cell (IFN system) will have important …

    lmu-germany Repository record

  12. The regulation of human airway epithelial expression of viperin by human rhinovirus

    Pelikan, Jonathan BenjaminGraduate Studies2012

    … and is dependent on induction and DNA binding of interferon regulatory factor 1 (IRF-1). We showed that CSE inhibits HRV-induced viperin mRNA and protein expression but that CSE does not alter HRV-induced promoter activation, raising the possibility that CSE-mediated inhibition of viperin …

    calgary Repository record

  13. Single molecule investigation of antiviral signaling

    Doganay, SultanUniversity of Illinois at Urbana-Champaign2014

    … leads to transcriptional activation of type I interferon (IFN). Type I IFN induces a large set of genes called interferon-stimulated genes (ISGs) that coordinate a response to antagonize viral invasion. We utilized single-molecule fluorescence in situ hybridization (smFISH) to study viral and …

    uiuc Repository record

  14. Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling

    Ling, Hsiang-Hsi, <p>0000-0002-1678-4845</p>2027

    … immune evasion. Fak ablates stimulator of interferon genes (Sting)-dependent type I interferon production when DTCs awaken from dormancy, thus preventing immune-mediated elimination. Fak may therefore represent the elusive arbiter of Sting’s role as both an anti- and pro-metastatic …

    uthsc Repository record

  15. A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment

    Schönheit, JörgUniversität Potsdam

    … or change in expression levels of transcription factors (TF) is causative to leukaemia. However, the molecular mechanisms driving specification into distinct phagocytes remain poorly understood. In the present study I identify the transcription factor Interferon Regulatory Factor 8 (IRF8) as the …

    potsdam-diss Repository record

  16. Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes

    이, 창석2011

    … I treated lipopolysaccharides(LPS)- or interferon gamma(IFN-stimulated rat brain astrocytes with two oxysterols, 7-ketocholesterol and 22(R)-hydroxycholesterol. In LPS-stimulated astrocytes, both oxysterols suppressed inducible nitric oxide synthase expression and nitric oxide release …

    ajou Repository record

  17. Characterization of the antiviral activity of cyclosporine A against dengue virus

    Sangwan, Ujjwal2024

    … cyclophilin A or B, which are not required host factors for DENV-2 in Huh7 and A549 cells. In Huh7 and A549 cells, CsA induces interferon regulatory factor-1 (IRF1)-dependent antiviral gene expression. While CsA does not increase IRF1 levels in Huh7 cells, it enhances IRF1 protein levels in A549 …

    queens Repository record

  18. Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance

    Melidosian, Bihui2020

    … we show that tumor anti-viral transcription factors alter the epigenome, which amplifies tumor type one interferon (IFN-I) signaling that mediates resistance. Across human and mouse tumors, elevated interferon (IFN) signaling in cancer cells is associated with distinct epigenetic features …

    penn Repository record

  19. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

    Svensson, EmelieDivision of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University2006

    … encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. The ojective of this thesis was to …

    lund Repository record

  20. Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)

    Gates-Tanzer, Lauren TaylorUniversity of Illinois at Urbana-Champaign2018

    … regulation and more recently, modulation of interferon responses. Interferon alpha (IFNa) and interferon beta (IFNb) are in the class of type I IFN and are critical as the first line of defense against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection …

    uiuc Repository record

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