Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Interferon Beta"”.
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Nursing Care for Outpatients with Multiple Sclerosis: Complex Approach and Medical-Social Aspects //// Сестрински грижи при пациенти с множествена склероза - комплексен подход и медико социални аспекти
… a patient's diary to track regular injections of Interferon Beta and to develop a step-by-step guide to the new Interferon Beta system.
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The effect of potential anticancer gene products on breast cancer cell lines
… different potential anticancer factors, decorin, interferon beta (IFNb), and tumor necrosis factor (TNF) related apoptotic inducing ligand (TRAIL). The overall hypothesis was that combinatorial treatment of two of anti-cancer factors would be more efficacious and exhibit less toxicity than single …
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Imaging and therapy in multiple sclerosis
… to initial treatment with glatiramer acetate or interferon beta over a median 5.8 years of follow-up. A lower risk of conversion was also associated with early (versus late) commencement of glatiramer acetate or interferon beta; and with early escalation from these therapies to fingolimod, …
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Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells
… we synthesized ssRNAs and tested the IFNp (interferon-beta) level and cellular toxicity of ssRNAs in SKOV3 cells. In this work, we confirmed that 5'-ppp-ssRNA (~ 60nt) was immunostimulatory and toxic in SKOV3 cells. 5'-ppp-ssRNA (~ 60nt) led to IFN-P induction and apoptosis in SKOV3 cells. …
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MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β
… Although it has been widely noted that interferon-beta; (IFN-beta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood. We describe here a novel …
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… separate studies we evaluated the efficacy of interferon beta (IFNβ), granulocyte-colony stimulating factor (G-CSF), and osteopontin (OPN) in reducing apoptosis and inflammation following neonatal hypoxic ischemic encephalopathy and have outlined the cellular pathways involved in their …
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Der Einfluß von Steroiden und Medikamenten zur Behandlung der Multiplen Sklerose auf die LPS-induzierte iNOS/NO-Synthese in primärer Mikroglia neugeborener Ratten
… keinen Effekt. Die bereits eingesetzten Pharmaka Interferon-beta (IFNß) und Copolymer-1 (Cop-1) übten in unseren Untersuchungen keinen hemmenden Effekt auf die iNOS/NO-Synthese aus. Von den bei der EAE mit Erfolg angewendeten Therapeutika zeigte der Transforming Growth Factor-beta (TGFß) eine …
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
… regulation and more recently, modulation of interferon responses. Interferon alpha (IFNa) and interferon beta (IFNb) are in the class of type I IFN and are critical as the first line of defense against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… Tumor Necrosis Factor-α (TNF-α) and anti-viral interferon- β (IFN-β) cytokines are highly expressed in MCV lesions and surrounding tissue. Despite the expression of pro-inflammatory factors, MCV infections cause little inflammation. Not surprisingly, MCV encodes immunomodulatory proteins such as …
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Zellspezifische Funktionen des Typ 1 Interferonrezeptors bei der experimentellen autoimmunen Enzephalomyelitis
… Erkrankung stellt die Verabreichung des Typ 1 Interferons Interferon-beta (IFN-beta) dar, welches die Schubrate um ca. 35 % reduziert und das Fortschreiten der Behinderungen bei schubförmig-remittierender MS verzögert. Die Wirksamkeit lässt allerdings in bis zu 30 % aller Fälle innerhalb eines …
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Cooperative Tumor Suppression by ARF and p53
… setting lead to the activation of a type I interferon response driven by interferon-beta and the STAT1 transcription factor. I further demonstrated that ARF and p53 cooperate to suppress the interferon response, and when both proteins are inactivated, interferon signaling can drive tumor …
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Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis.
… (STAT1) and 2 (STAT2) are primarily activated by interferons and play a central role in orchestrating responses to a variety of pathogens by activating the transcription of nuclear encoded genes that mediate antiviral, antigrowth and immune surveillance responses. In addition to their nuclear …
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Single molecule investigation of antiviral signaling
… leads to transcriptional activation of type I interferon (IFN). Type I IFN induces a large set of genes called interferon-stimulated genes (ISGs) that coordinate a response to antagonize viral invasion. We utilized single-molecule fluorescence in situ hybridization (smFISH) to study viral and …