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Showing 1 to 20 of 122 for “"Interferon (IFN)"”.

  1. Sindbisvirus aktivierte ISRE-bindende Komplexe in L-929- Zellen

    Behr, MatthiasUniversität Würzburg

    … haben wir in den Extrakten infizierter Zellen. Interferon(IFN)- stimulated- response- element (ISRE)- Bindungsproteine untersucht, welche in der transkriptionellen Induktion von IFN Typ I induzierter Gene beteiligt sind. Mittels Gelretentionsanalyse in der ein humanes Interferon-stimuliertes Gen …

    wurz-thes Repository record

  2. ISRE-bindende Komplexe nach Sindbisinfektion in Mäuse- und Hühnerzellen

    Bühr, Patrick M.Universität Würzburg

    … haben wir in den Extrakten infizierter Zellen. Interferon(IFN)- stimulated- response- element (ISRE)- Bindungsproteine untersucht, welche in der transkriptionellen Induktion von IFN Typ I induzierter Gene beteiligt sind. Mittels Gelretentionsanalyse in der ein humanes Interferon-stimuliertes Gen …

    wurz-thes Repository record

  3. Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance

    Melidosian, Bihui2020

    … the epigenome, which amplifies tumor type one interferon (IFN-I) signaling that mediates resistance. Across human and mouse tumors, elevated interferon (IFN) signaling in cancer cells is associated with distinct epigenetic features that predict poor CD8 T cell infiltration. This includes …

    penn Repository record

  4. Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity

    Dorta-Estremera, Stephanie M, Ph.D.2016

    … dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that stimulate the development of humoral autoimmunity as a …

    uthsc Repository record

  5. The Biology of Dendritic Cells in the Context of Autoimmunity

    Qiu, Connie ClaireTemple University. Libraries2019

    … worldwide. An increased expression of type I interferon (IFN) regulated genes is a hallmark of SLE, but the precise etiology of SLE initiation and flares is poorly understood. Because plasmacytoid dendritic cells (pDCs) are the primary type I IFN producers, their role in SLE has long been …

    temple Repository record

  6. Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy

    Beauregard, CarolineUniversité d'Ottawa / University of Ottawa2016

    … factor alpha (TNFα). I hypothesize that type I interferon (IFN) stimulation in cancer cells and in immune cells leads to the production of TNFα, which can then synergize with SMCs to kill cancer cells. The combined treatment of SMC and IFNα induces tumour regression in mice, and this effect is …

    ottawa-retro Repository record

  7. Functional study of the IFITM1 gene related to tumor progression of NF1

    송, 은미2011

    … 변화 24 E. IFITM1 과발현에 의한 apoptosis 감수성 변화 25 F. Interferon(IFN)의 처리에 의한 IFITM1의 발현량 증가 27 G. IFITM1의 세포 내 분포(cellular localization) 28 H. IFITM1 과발현에 의한 미토콘드리아 형태 변화 28 I. IFITM1 과발현에 의한 미토콘드리아 형태조절 단백질의 발현량 변화 32 Ⅳ. 고찰 34 Ⅴ. 결론 38 참고문헌 40 ABSTRACT 47 "

    ajou Repository record

  8. Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus

    Bhoj, Vijay Garud2010

    … which includes the production of anti-viral interferons. TLRs 3, 4, and 7/8 and the RLR, RIG-I, are the primary PRRs involved in the recognition of RNA viruses and they signal through the adaptors TRIF (TLR3, 4), MyD88 (TLR4, 7/8, 9), and MAVS (RIG-I). The innate response serves to limit …

    utswmed Repository record

  9. Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells

    Wang, Jundi2018

    … agents. Using the expression of type I interferon (IFN) as a benchmark of antiviral responses, our results indicated that the type I IFN were robustly induced in C3Hl0Tl/2 cells, but not in ESCs, when they were exposed to polyinosinic:polycytidylic acid (poly(I:C), a dsRNA viral analog) …

    usm Repository record

  10. Functional Analysis of the Molluscum Contagiosum Virus MC160 Death Effector Domain-Containing Protein RxDL Motif

    Weber, Sarah2015

    … responses such as apoptosis and activation of interferon (IFN). Presumably, MC159 and MC160 bind to host DED-containing proteins as a means to prevent the formation of innate immune signaling complexes. The RxDL motif is conserved among several host and viral DED-containing proteins and has …

    shu-thes Repository record

  11. Characterization of cholesterol 25-hydroxylase expression in human macrophages

    Magoro, Tshifhiwa2019

    … appreciated connection between type I interferon (IFN-I) and lipid metabolism. Moreover, the details of this connection appear to differ in mouse and human cells. Nevertheless, the molecular basis for the induction of CH25H in humans is not known. Objective Elucidation of signaling and …

    venda Repository record

  12. The effects of dietary β-glucan supplementation on performance and immune response of broiler chicks during an Eimeria challenge

    Cox, Chasity MarieVirginia Tech2009

    … the expression of interleukin (IL)-8, IL-18, interferon (IFN)-γ and inducible nitric oxide synthase (iNOS) in the small intestine. A subsequent study was conducted to investigate the effects of dietary β-glucan on broiler chick (1440 birds) performance and immune response during a mixed …

    vt Repository record

  13. Subversion of innate antiviral immunity by SARS-CoV-2: An example from the study of nonstructural protein 16.

    Schindewolf, Craig Daniel 1987-The University of Texas Medical Branch at Galveston2022

    … the NSP16 mutant is more sensitive to type I interferon (IFN-I) in vitro. Furthermore, silencing IFIT1 or IFIT3, IFN-stimulated genes that sense a lack of 2’-O methylation, partially restores fitness to the NSP16 mutant. Conversely, overexpressing IFIT1 either alone or in combination with …

    utmb Repository record

  14. Scalable computational architecture for integrating biological pathway models

    Shiva, V. AMassachusetts Institute of Technology2007

    … approach. A new integrative model of the interferon (IFN) response to virus infection is developed using Cytosolve. Each model within the integrated model, spans different time scales, is created by different authors from four countries and three continents across different disciplines, is …

    mit Repository record

  15. Studies on the interaction between porcine reproductive and respiratory syndrome virus and its natural host cell

    Chen, Wei YuUniversity of Illinois at Urbana-Champaign2016

    … ability of PRRSV to modulate the production of interferon (IFN)a and tumor necrosis factor (TNF)a by affected AMΦ is implicated in the virus’s pathogenesis. In this regard, infection of porcine AMΦ with PRRSV reduced by >50% the amount of IFN-α otherwise produced following the cells’ exposure to …

    uiuc Repository record

  16. Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells

    Chrisikos, Taylor, <p>0000-0001-8966-4046</p>2022

    … induces numerous inflammatory pathways in cDC1s, interferon (IFN) signaling was selectively inhibited by IL-10 and STAT3. Furthermore, assessment of the relative contribution of each IFN type indicated that type I IFN is the primary target of STAT3-mediated inhibition. To determine the impact of …

    uthsc Repository record

  17. Cytokines and aeroallergens in the pathogenesis of summer-pasture associated obstructive pulmonary disease: effects on endothelin production, neutrophil activation and chemotaxis

    Costa, Lais Rosa RodriguesVeterinary Medical Sciences - Pathobiological Sciences2022

    … cytokines, interleukin (IL)-8 and IL-4, but not interferon (IFN)-γ, tended to be greater in lungs of SPAOPD-affected than non-affected horses. The immunoreactive ET-1 distribution tended to be greater in airway tissues of affected horses. The putative aeroallergens, grass pollen & mold spores, …

    lsu-thes Repository record

  18. The role of type I interferon in chronic lymphocytic leukemia

    LUO, YU XUAN2024

    Type I interferon (IFN) has pleotropic and context-dependent biological effects. IFN's involvement in viral infections is well known but its precise role in cancer remains elusive. The aims of this thesis were to study the role of IFN in chronic lymphocytic leukemia (CLL), the most common adult …

    toronto-retro Repository record

  19. Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon

    Davis, Ann Marie2010

    … cytokines interleukin 12 (IL-12) and type I interferon (IFN-alpha/beta) are produced in response to intracellular bacterial and viral infections. While the effects of IL-12 on CD4+ T cell differentiation are relatively well-understood, the role of IFN-alpha/beta, despite extensive study, has …

    utswmed Repository record

  20. HIJACKING OF CELLULAR PATHWAYS BY NOVEL TICK-BORNE PHLEBOVIRUS

    Silvas, Jesus AThe University of Texas Medical Branch at Galveston2021

    … SFTS virus pathogenesis is known. Inhibition of interferon (IFN) responses by SFTS virus NSs has been shown to correlate with the relocation of RIG-I signaling proteins into early endosomal-derived cytoplasmic structures positive for SFTS virus NSs. Moreover, ubiquitin, an important …

    utmb Repository record

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