Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 107 for “"Intercellular communication"”.
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Investigating viral subversion of intercellular communication
… immunological, metabolic, and electrical intercellular communication. The gap junction protein connexin43 (Cx43; gene name – GJA1) is the most widely expressed human connexin protein and is the predominant connexin in the working myocardium. Given the immunological role for Cx43 gap …
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Mechanisms of Intercellular Communication During Breast Cancer Progression Through Metastasis
… breast cancer patient deaths. While the role of intercellular communication in metastasis, either among cancer cells, or between cancer cells and the tumor microenvironment is well established, additional research on specific molecular and cellular mechanisms underlying these interactions is …
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Intercellular communication in uropathogenic Escherichia coli and the probiotic Lactobacillus reuter
The role of bacterial interspecies communication in the progression of urinary tract infections has yet to be studied. This study sought to characterize the role of autoinducer 2 (AI-2) in the regulation of virulence factors of uropathogenic Escherichia coli J96, determine if the probiotic …
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The role of tunneling nanotubes in mediating intercellular communication in cancer
… as an invasive unit. Effective and efficient intercellular crosstalk in the three-dimensional complex tumor microenvironment is essential for cancer progression. A relatively new mechanism of intercellular communication has been identified in the form of a unique cellular protrusion called …
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TISSUE ARCHITECTURE AND INTERCELLULAR COMMUNICATION: MEDIATORS OF PROTECTIVE OR PATHOGENIC INTERFERON RESPONSES
… immune responses. Using these models allowed for intercellular communication, and thus advanced our ability to evaluate interferon responses using in-vitro systems that closely model in-vivo settings. My thesis work highlights the delicate balance of interferon signaling to avoid unwarranted …
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Functional study of Gap Junctional Intercellular Communication in Human Keratinocyte Cell Line
… unique membrane structures that mediate the intercellular communications among almost all tissues, are composed of connexins in vertebrate. The essential role of gap junction-mediated intercellular communications(GJIC) for coordination of cell homeostasis, tissue functions and organ …
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Integrated experimental and computational analysis of intercellular communication with application to endometriosis
Cell-cell communication is critically important to the function of the immune system, allowing a systems-level determination of the appropriate type of immune response to a perturbation. The immune system has at its disposal multiple types of responses, some beneficial and others harmful, all of …
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Engineering Redox-based Intercellular Communication Channels Towards the Control of Microbial Consortial Behavior
… communities participate in various modes of intercellular communication, a process in which cells relay information across potentially large distances through molecular interactions. The advent of synthetic biology has enabled facile manipulation of the genetic architectures governing these …
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Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin
… I focused on identifying downstream results of intercellular communication between melanocytes and keratinocytes for each of these cell types. I characterized the transcriptomes of human melanocytes and keratinocytes that were freshly derived from human tissue in Chapter 2. These data served as …
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Human Brain Organoids for Studying Malignant Cell States and Intercellular Communication in Human Glioma
… highlighted the heterogeneity and inter-cellular communication within these tumors; it follows that appropriate models for studying glioma behavior and progression – and, in turn, therapeutic avenues – must adequately recapitulate these key features. Indeed, patientderived tumor xenografts (PDXs) …
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Effects of DDT and DDE on gap junctional intercellular communication in human mammary epithelial cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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RADIATION-INDUCED CHROMOSOME INSTABILITY AND INTERCELLULAR COMMUNICATION: THE ROLE OF DOSE RATE AND IMPLICATIONS FOR CARCINOGENESIS
The biological risks associated with low dose and low dose rate (LDR) radiation exposures are not yet well characterised. Experimental studies indicate that in addition to biological effects resulting from direct DNA damage, a variety of non-DNA targeted effects (NTE) including radiation-induced …
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The Role of Connexin43 and Gap Junctional Intercellular Communication in the Apoptotic Process of Auditory Cells
Cis-diamminedichloroplatinum (cisplatin) is one of effective chemotherapeutic drugs for cancer therapy. Nevertheless, most patients treated with cisplatin are exposed to high risk of ototoxicity such as hearing loss or dizziness. It has been reported that ototoxicity occurs in about 75-100 % of …
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Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication
Gap junctional intercellular communication (GJIC) may play an important role in the hearing process. Cisplatin is an anticancer drug that causes hearing loss and Gingko biloba extracts (EGb 761) have been used as an antioxidant and enhancer for GJIC. The purpose of this study was to examine the …
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The use of cultured cells with defects of citrulline metabolism in diagnosis and in the study of intercellular communication
… occurred by the exchange of metabolites via intercellular junctions between the two cell types. Co-cultures of ASS⁻ and ASL⁻ cells were used as an assay system for measuring intercellular junctional communication. This allowed quantitation of the effects of pH and extracellular divalent …
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MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS
… and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means by which immune …
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BUBR1 in Cardiac Biology: From Cardiogenesis to Adult Heart Function and Aging
… in cardiac morphogenesis, cardiac aging, intercellular communication, and wound healing, uncovering novel regulatory pathways that contribute to both developmental and degenerative cardiac conditions. Our findings demonstrate that BubR1 is indispensable for embryonic cardiac development. …
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Microfluidic platforms for studying cell behavior in complex microenvironments
… to study (1) neutrophil chemotaxis, (2) intercellular communication, and (3) cell behavior under controlled oxygen conditions. In chapter 1, conventional methods and emerging techniques using microfluidic platforms to study cell behavior in complex microenvironments are discussed. In …
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Investigating The Role of Exosomal Communication In The Glioma Microenvironment
… vesicles, termed exosomes, may contribute to intercellular communication within the tumor niche. Therefore, I hypothesized that GA-MSC-derived exosomes increase the growth and evolution of gliomas. Here I show for the first time that exosomes can be isolated from patient-derived GA-MSCs and …
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Phosphorylation kinetics of cardiac gap junction regulation during stress
… manifest with disrupted gap junctional intercellular communication which can generate potentially fatal arrhythmias, thus, it is essential to elucidate mechanisms underlying Cx43 regulation and altered intercellular communication. Phosphorylation of residues in the Cx43 carboxyl terminus …
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