Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Intercellular Signaling Peptides and Proteins"”.
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From Bud to Organ: An In Depth Analysis of the Development of the Pancreas.
… development was conducted in order to expand our understating of the biology of this organ. This thesis encompasses an in depth description of pancreas macro morphology throughout development as well as the analysis of the role of signaling molecules not previously studied in the pancreas. …
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The Role of Progranulin in Frontotemporal Dementia
… disease. FTD is a highly heritable disease, and one of the most common genetic causes is heterozygous loss-of-function mutations in GRN, the gene that encodes the protein progranulin. In order to treat GRN-FTD, our lab developed small molecule enhancers of GRN expression which boost …
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Cell Migration and Survival Pathways in Cardiac Development and Disease
… files ("*.asf", "*.avi") are supplemental files and may be viewed individually.
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Studies on Cellular Nutrient Responses and Protein Degradation
… Amino-acid abundance promotes protein synthesis and cell growth via activation of the protein kinase mTOR, while amino-acid deprivation promotes protein degradation by autophagy. The heterodimeric G protein coupled receptor (GPCR) T1R1-T1R3 can act as an extracellular sensor for amino acids, …
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HIF-2: Standing Guard at the Crossroads of Stress and Aging
… subunit of Hypoxia inducible factors (HIF-1alpha and HIF-2 alpha). HIF-1 alpha and HIF-2 alpha have similar structural organization, and after forming an obligate heterodimer with the common partner ARNT/HIF-1 alpha, bind to the same recognition element located in target gene promoter or enhancer …
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
… cause of male cancer death in the United States, and is considered a health disparity because of its disproportionate incidence and mortality in African American (AA) males. A major challenge in PCa treatment is its recurrence into hormone refractory prostate cancer (HRPC). Docetaxel is the …