Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Intercalated Disc"”.
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The role of the perinexus in Long QT Syndrome Type 3
… nanodomain with high density of Nav1.5 in the intercalated disc. Following this finding, we found that elevating extracellular sodium and widening the perinexus synergistically exacerbated LQT3 phenotype, Importantly, we also found that perinexal expansion increases the susceptibility to …
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Phosphorylation kinetics of cardiac gap junction regulation during stress
… at regions of contact between cells known as the intercalated disc to facilitate cellular coupling. Cardiac pathologies frequently manifest with disrupted gap junctional intercellular communication which can generate potentially fatal arrhythmias, thus, it is essential to elucidate mechanisms …
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The Relationship between Ephaptic Coupling and Excitability in Ventricular Myocardium
… sodium channels are densely expressed in the intercalated disc within the perinexus, which is two orders of magnitude narrower than bulk extracellular interstitium. The biphasic relationship between conduction and perinexus is well-researched and consistent between computations models. We …
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Development of a Model System for Culturing Neonatal Rat Ventricular Myocytes in vitro to Monitor Integrin Activation in Response to Altered Contractile Force
… disorganization of myofibril structure and intercalated disc formation, making it difficult to determine the physiological relevance. Therefore, we have developed an in vitro tissue model to mimic in vivo physiology. Specifically, we have developed a flexible micropatterned scaffold to …
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Interplay between Ephaptic and Gap Junctional Coupling in Cardiac Conduction
… extensively studied. However, there are several discrepancies in cardiac electrophysiology research that have extended over decades, suggesting elements that are still not completely understood about this complex phenomenon. This dissertation will focus on one such mechanism, ephaptic coupling …
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Defining a Novel Role for the E3 Ubiquitin Ligase Wwp1 in Cardiac Arrhythmogenesis
… cardiomyocytes in a structure known as the intercalated disc (ID). Each gap junction is composed of protein subunits called connexins (Cx) that work in concert to maintain a coordinated wave of electrical excitation among cardiomyocytes in order to ensure a proper and synchronized …
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Zell-Zell- und Zell-Matrix-Kontakte während der Muskelentwicklung
Im Rahmen dieser Arbeit wurden zwei humane Varianten des von Wang et al., 1999, erstmals beschriebenen muskelspezifischen Proteins Xin (Huhn und Maus) über Sequenzanalyse, Immunofluoreszenzmikroskopie, Transfektionsstudien und biochemischer Analyse näher charakterisiert. Die Proteine wurden mit …
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Sodium Channel Loss of Function Sensitizes Conduction to Changes in Extracellular Sodium Concentration
Sudden cardiac death is largely attributable to sudden onset ventricular arrhythmias. Alterations in cardiac conduction, particularly the slowing of conduction velocity is one major factor in arrhythmogenesis. By understanding the mechanisms and factors that modulate cardiac conduction velocity, we …