Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 159 for “"Interactors"”.
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Role of ASCL1 and Its Interactors in Neuroblastoma
… fully understood but is likely to involve ASCL1 interactors regulating its transcriptional activity on chromatin. In this dissertation, the mechanisms by which ASCL1 induces differentiation are explored by characterising its genome-wide transcriptional targets, chromatin binding, whole proteome …
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Identification and characterisation of novel interactors of surfactant protein C
… the mechanisms of SFTPC trafficking and their interactors in health and disease is crucial to defining how pathogenic variants induce cellular dysfunction. To investigate trafficking components required for SFTPC trafficking that are perturbed by the I73T variant, I undertook SFTPC-WT and -I73T …
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Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue
Voltage-gated sodium (Nav) channels play a critical role in the initiation and propagation of action potentials in excitable cells and are involved in numerous neurological diseases such as epilepsy, neuropathic pain, and cancer. Although approved drugs targeting Nav channels are available, they …
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Establishing new approaches to unveil regulatory functions of tRNAs and their interactors
… it is possible to quantitatively identify direct interactors and provide a solution to the problem of infinite ratios within a given SILAC dataset. The abundance of YARS-binding partners provided further evidence to the notion that aaRSs have functionally co-opted their tRNA binding site over …
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Genetic interactors of the SWI/SNF chromatin remodelling complex in Caenorhabditis elegans
Chromatin remodellers are adenosine triphosphate (ATP)-powered molecular machines that can directly alter the structure of chromatin by reshuffling or evicting nucleosomes. Thereby they control the access to DNA elements like promoters and replication origins that need to be exposed to execute …
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AMPHIPODS ARE STRONG INTERACTORS IN THE FOOD WEB OF A BROWN-WATER SALMON RIVER
<p>Marine derived biomass from salmon carcasses is incorporated into coastal Pacific Rim salmon river systems via the organisms and structures of the freshwater foodweb. In brown water rivers of Western Kamchatka, the foodweb is dominated by ubiquitous benthic amphipods (Anisogammarus kygi) that …
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AMPHIPODS ARE STRONG INTERACTORS IN THE FOOD WEB OF A BROWN-WATER SALMON RIVER
<p>Marine derived biomass from salmon carcasses is incorporated into coastal Pacific Rim salmon river systems via the organisms and structures of the freshwater foodweb. In brown water rivers of Western Kamchatka, the foodweb is dominated by ubiquitous benthic amphipods (Anisogammarus kygi) that …
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Characterising GIGANTEA interactors: the BELL-LIKE HOMEODOMAIN 3 and BELL-LIKE HOMEODOMAIN 10 proteins
… the role of this protein is to identify protein interactors. The aim of this thesis project was to characterise proteins that interacted with GI. Previously, the BELL-LIKE HOMEODOMAIN 3 (BLH3) protein was identified as a putative GI protein interactor. As part of this thesis work, yeast 2-hybrid …
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Biochemical and Biophysical Studies of the UPR Kinase PERK and its Interactors in Health and Disease
The unfolded protein response (UPR) is a protective cellular mechanism that restores protein folding homeostasis under conditions of endoplasmic reticulum (ER) stress. The PERK-eIF2α branch of the UPR is activated by the accumulation of misfolded proteins in the ER lumen. PERK, upon activation …
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Identification and characterization of genetic interactors of the Rho Guanine-nucleotide exchange factor Pebble in <em>Drosophila</em>
… in eye morphology was used to find genetic interactors. Results of a screen using chromosomal deletions and an EMS-based screen revealed candidates, which genetically interact with Pbl and are required for mesoderm cell migration. In addition, a structure-function analysis of the Pbl protein …
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The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules
… NTF2L and SLiMs not only introduce NTF2L direct interactors into the SG interaction network, but these SLiM-containing proteins also serve as bridges, connecting many other SG components into the SG interaction network. Caprin1 bridges NTF2L and small ribosomal proteins, NUFIP2 bridges NTF2L and …
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Identification of host proteins targeted by the flax rust effector protein AvrL567
… as potential fungal cofactors. Eight putative interactors (iA1 to iA8) were isolated for AvrL567, none could be identified for AvrM. The candidates identified in the Y2H screen were truncated proteins. Two of them showed low sequence homology to fungal proteins, three putative interactors had …
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Identification of host proteins targeted by the flax rust effector protein AvrL567
… as potential fungal cofactors. Eight putative interactors (iA1 to iA8) were isolated for AvrL567, none could be identified for AvrM. The candidates identified in the Y2H screen were truncated proteins. Two of them showed low sequence homology to fungal proteins, three putative interactors had …
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Chromatin Regulators of MYC Oncoprotein Activity in Cancer
… are still needed. We hypothesize that chromatin interactors are critical for MYC to achieve transcriptional control and biological outcomes. Our proteomic study of the MYC interactome yielded chromatin complexes and epigenetic regulators. In this thesis, we investigated two MYC-interacting …
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Identification of surface protein complexes of Streptococcus pyogenes through protein microarray technology
… interactions, i. e. binding of the same two interactors irrespective of which of the two partners is in solid-phase or in solution, were taken as bona fide protein-protein interactions. Using this approach, we have identified 20 interactors of one of the potent toxins secreted by GAS and …
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Analysis of Human Interferon Signaling and its Regulation
… proximity labeling to identify putative interactors of all seven canonical type I IFN signaling members, IFNAR1, IFNAR2, JAK1, TYK2, STAT1, STAT2, and IRF9, at various times post type I IFN stimulation. Using highly stringent selection criteria and label-free quantification (LFQ) this led …
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Interaction Mapping of the Atypical Protein Kinase WNK3
… has been to build a collection of putative WNK3 interactors to serve as a source of information and project leads for the ongoing research program of the Cobb laboratory. The yeast two-hybrid screens described here have yielded hundreds of putative interactors. While this written work deals only …
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Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
… This permitted identification of transient NTD interactors, previously unresolved using classical affinity-purifications. Furthermore, this technique provides a comprehensive list of diverse synaptic cleft proteins, which may influence AMPAR function through direct or indirect mechanisms. …
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An Examination of Information Processing in Initial Interaction Through Linking Input, Structure and Outcome: Effects of Preinteraction Expectancies on Interpersonal Attraction and Interaction Structure
… solely on the beliefs and perceptions which interactors make about an other's behavior, then controlling interaction would ultimately depend on controlling attribution.
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Structural principles governing kinase specificity towards RNA polymerase II C-terminal domain and their impact on transcription
… specificity of kinases, we use them to identify interactors by generating phosphorylated substrates in vitro and identifying differential interactors as explained in Chapter 4.
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