Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Interactomics"”.
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INTERACTOMICS FOR RICE FLOWERING: A PROXIMITY LABELLING APPROACH
Il controllo della fioritura nel riso (Oryza sativa) si snoda su un complesso meccanismo di induzione che integra gli stimoli ambientali nelle foglie e trasmette un segnale al meristema apicale della pianta per indurne la transizione riproduttiva. Il fattore di trascrizione Hd1, omologo di CONSTANS …
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Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs
Ubiquitination is a prominent reversible post-translational modification, which plays crucial roles in regulating numerous cellular events. Conversely, deubiquitination is the removal of ubiquitin/polyubiquitin chains from ubiquitinated proteins. Deubiquitination is carried out by the class of …
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Type I collagen proteostasis
… I use a quantitative mass spectrometry-based interactomics approach and a novel human cell-based model system to map the components of the wild-type collagen-I proteostasis network. This approach resulted in the discovery of > 25 new putative proteostasis mechanisms that engage collagen-I, as …
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Structural and functional characterisation of pUL21, an α-herpesvirus phosphatase adaptor protein
… remained unknown. Using a high throughput interactomics screen, previous members of the group identified potential cellular binding partners of pUL21: protein phosphatase 1 (PP1) and ceramide transfer protein (CERT). This thesis presents biophysical characterization of the direct …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… biomarkers. Previously generated *in vivo* interactomics data identified the RTK/IRS network as the primary driver of homeostatic PI3K activation in healthy mouse prostate, and PLEKHS1 as the primary driver of oncogenic PI3K activation in cancerous, PTEN-null mouse prostate. PTEN phosphatase …
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Changes in the Rpb3 Interactome Caused by the Deletion of RPB9 in Saccharomyces cerevisiae
RNA Polymerase II (Pol II) is the primary actor in the transcription of mRNA from genes. Pol II is a complex composed of twelve protein subunits. This study focused on the changes in the interactome of Rbp3 in S. cerevisiae when the Pol II subunit Rpb9 is removed. Rpb3 is one of the core subunits …
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Commonalities between SMA and ALS: investigation of ribosome heterogeneity and translational defects
… common molecular trait connecting SMN and MATR3. Interactomics analysis of SMN-primed ribosomes revealed that MATR3 protein is also a top interactor. In addition, MATR3 has recently been shown to associate with the translational machinery and control the translation efficiency of a specific subset …
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Elucidating the molecular mechanisms of p110δ activation in T cell antigen receptor signalling
Phosphoinositide 3-kinases (PI3Ks) are activated in immune cells downstream of the antigen recognition receptors, the signals from which are crucial for the development, differentiation and activation of lymphocytes. Engagement of the T cell antigen receptor (TCR) initiates a signalling cascade …
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Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes
The mammalian target of rapamycin (mTOR) is an intracellular protein kinase that plays a key role in the control of cell growth, differentiation, cell survival, and cell proliferation. In humans, mTOR deregulation is implicated in parasitic, fungal, bacterial and viral infections, immune disorders, …
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Protein interaction studies on the titin A150 domain using proximity-dependent biotinylation
Titin is an enormous protein that spans over 1 µm in the sarcomere, making it the largest protein in the human body. A single missense variant within the titin A150 domain, also called FN3 119, is sufficient to cause a dominant myopathy known as Hereditary Myopathy with Early Respiratory Failure …
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Large Scale Cross-Linking Mass Spectrometry as the Missing Link in the Systems Biology Toolbox
The function of a protein is mediated by its ability to form precise three-dimensional structures or specific protein-protein interaction (PPI) interfaces. However, it has been challenging to study these aspects of the proteome at scale, in sufficient detail, and in a generalisable way. …