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Showing 1 to 20 of 145 for “"Interactome"”.

  1. An Hsp90 physical interactome

    Kolhe, Janhavi AtitUniversity of Illinois at Urbana-Champaign2022

    Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms

    uiuc Repository record

  2. The TAZ Protein Interactome in Striated Muscle

    Kelebeev, Jonathan2023

    … study aimed at identifying the TAZ interactome in striated muscle cells. Using a novel GFP-Nanotrap based affinity purification approach coupled with LC-MS/MS protein identification, we document a comprehensive list of known and novel TAZ interactome components in myogenic cells. TAZ …

    york Repository record

  3. Mapping the cell cycle-dependent centrosomal interactome

    Renzhi, YaoThe University of Edinburgh2025

    … 2, PCNT and Cep192 to detect the centrosome interactome. The cell cycle-dependent interactome of the centrosome was mapped by combining proximity biotinylation and a reversible drug-mediated cell cycle synchronisation method based on the CDK4/6 inhibitor palbociclib. Differential analysis of …

    edinburgh Repository record

  4. The Drosophila Interactions Database: Integrating The Interactome And Transcriptome

    Murali, Thilakam2013

    … in DroID and I anticipate that studies on interactome networks using this filter will further our understanding of biology.</p>

    wayne-thes Repository record

  5. Cell Type-specific Analysis of Human Interactome and Transcriptome

    Mohammadi, Shahin

    Cells are the fundamental building block of complex tissues in higher-order organisms. These cells take different forms and shapes to perform a broad range of functions. What makes a cell uniquely eligible to perform a task, however, is not well-understood; neither is the defining characteristic …

    purdue-thes Repository record

  6. Bioinformatic methods for analyses of epigenome and RNA interactome

    Yu, PengfeiUniversity of Illinois at Urbana-Champaign2015

    The sequenced genetic codes for multiple species have provided great sources for understanding how a single genome can give rise to a complex organism. However, only a small percent of mammalian genome could be identified as protein-coding genes. Our understanding of the genome is far from …

    uiuc Repository record

  7. Investigating the TrkB Interactome during Development and in Neurodegeneration

    Zbiegly, JuliaUniversity of Cambridge2023

    … This suggests a remodelling of the TrkB interactome during development and that BDNF modulates the nascent proteome in adult brain via different mechanisms. To elucidate possible new roles and regulatory mechanisms of TrkB in the mature brain, we screened for novel protein interactions in …

    cambridge Repository record

  8. The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation

    Doreth, ChristianUniversity of Cambridge2021

    … I set out to identify the PLK1 and NLRP3 interactome during NLRP3 inflammasome activation, which could indicate the underlying mechanism of how PLK1 regulates NLRP3. Using proximity-dependent biotin identification (BioID), a method based on fusion of a promiscuous biotin ligase to a …

    cambridge Repository record

  9. Investigating the polyphosphate interactome with lysine- and histidine-rich proteins

    Lehotsky, Kirsten2024

    … unclear, we suggest that the polyP-protein interactome is involved in widespread regulatory mechanisms of protein homeostasis and human health.

    queens Repository record

  10. DISSECTING THE FUNCTION AND INTERACTOME OF PLEKHS1 IN PROSTATE TUMORIGENESIS

    Jung, Piotr KrzysztofUniversity of Cambridge2021

    Phosphatidylinositol(3,4,5)trisphosphate (PI(3,4,5)P3 or PIP3) is the lipid product and key signalling output of Class I phosphoinositide 3-kinases (PI3Ks) and acts as a coordinator of a huge network that controls cellular processes such as metabolism, cell growth and movement. Mutations that …

    cambridge Repository record

  11. Proteomic characterisation of Estrogen Receptor (ERα) interactome in breast cancer

    Papachristou, EvangeliaUniversity of Cambridge2020

    … observations and the dynamics of protein interactomes have until recently been largely unexplored. Here, we describe the development and application of a quantitative multiplexed method, termed qPLEX-RIME, which integrates RIME with isobaric labelling for the study of protein interactome …

    cambridge Repository record

  12. Net-PPI : mapping the human interactome with machine learned models

    Schreiber, KfirMassachusetts Institute of Technology2018

    The miracle of life is only possible thanks to a wide range of biochemical interactions between assortments of molecular agents. Amidst these agents, which enable all cellular activities, proteins are undoubtedly among the most important groups. Proteins facilitate countless intra- and …

    mit Repository record

  13. Identification of the Pokeweed Antiviral Protein Interactome by Co-Immunoprecipitation-Mass Spectrometry

    Chivers, Jennifer Anne2022

    … the role of PAP by mapping out the PAP-protein interactome; this will elucidate PAP’s function by implicating the processes in which it is involved. Co-immunoprecipitation coupled with mass spectrometry was used to identify PAP protein interactors in pokeweed. Results identified protein …

    york Repository record

  14. Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway

    Hsu, Wei-Chun JThe University of Texas Medical Branch at Galveston2021

    … downstream studies to comprise a focused GSK-3 interactome regulating the Nav complex. By combining biochemical assays, high-content confocal imaging, mass spectrometry, and patch-clamp electrophysiology, we show that alteration of this focused GSK-3 interactome, comprised of Akt, Wee1, and CK2, …

    utmb Repository record

  15. THE HCMV INTERACTOME: A QUANTITATIVE ANALYSIS OF HUMAN CYTOMEGALOVIRUS-HOST PROTEIN INTERACTIONS

    Veiga Nobre, LuisUniversity of Cambridge2020

    … its importance in viral replication. The interactome data will be important for future studies of herpesvirus infection.

    cambridge Repository record

  16. Study of the DNA Damage Complexes Within the HTLV-1 Tax Oncoprotein Interactome

    Belgnaoui, Sidi Mehdi2019

    <p>Human T-cell leukemia virus type 1 (HTLV-1) is a transforming retrovirus that can give rise to adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Tax is a virally encoded oncoprotein that is involved in HTLV-1 mediated cellular transformation. It …

    odu Repository record

  17. Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins

    Ahmed, Suaad M.National University of Ireland Maynooth2012

    Toll-like receptors (TLRs) are germline-encoded pattern-recognition receptors that initiate innate immune responses by recognising molecular structures shared by a wide range of pathogens, known as pathogen-associated molecular patterns (PAMPs). TIR domain-containing adaptor inducing IFN-β (TRIF) …

    maynooth Repository record

  18. Evaluating Chemical Crosslinking as a Tool for Enhancing DNA Damage Repair Interactome Analysis

    Shariat-Panahi, AliCumming School of Medicine2022

    … workflow can improve the coverage of DSB repair interactome in S. cerevisiae. To this end, I first evaluated and optimized the RIME protocol for isolating affinity-tagged putative EBC members after DSB-induction. Further, I tested various strategies for incorporating chemical crosslinking into …

    calgary Repository record

  19. Interactome Analysis Identifies Novel Targets of Phosphoinositide 3-kinase (PI3K) that Mediate Astrocyte Neuroprotection

    Alqawlaq, Samih Ahmad2019

    In a homeostatic state, astrocytes can support neuronal survival and function through a range of secreted signals that protect against neurotoxicity, oxidative stress, and apoptotic cascades. Thus, the analysis of astrocyte conditioned media (ACM) may provide valuable insight into the nature of …

    toronto-retro Repository record

  20. Mapping the metabolic protein interactome that supports energy conservation at the limits of life

    Williams, Seré Anne, author, Santangelo, Thomas, advisor, Hansen, Jeffrey C., committee member, Pilon, Marinus, committee member, Anderson, G. Brooke, committee member, Snow, Christopher, committee memberColorado State University. Libraries2024

    … kodakarensis) by mapping the metabolic protein interactome using affinity purification mass spectrometry (AP-MS) and generating engineered strains where fusion proteins selectively redirect electron flux in vivo. Twenty-five proteins involved in distinct metabolic functions were tagged to reveal …

    colostate Repository record

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