Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 97 for “"Interaction network"”.
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Protein-Protein Interaction Network Alignment
… forming protein complexes. A protein -protein interaction network is a graph that consists of proteins as vertices and their interactions as edges. Protein-protein interaction network alignment is very important in identifying protein complexes and predicting protein functions. Many algorithms …
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Characterization of the p23 interaction network
… Through their broad binding capacity, transient interactions, and high cellular abundance, the Hsp70 and Hsp90 chaperone families promote folding of a diverse clientele in numerous cellular compartments and organelles. An often-underappreciated aspect of this activity is the ability to modulate …
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Building the Human Argonaute 2 Interaction Network
… the nuclear target. However, the protein-protein interactions and mechanisms involved remain unclear. Identification and understanding of the interactions of AGO proteins in the nucleus is essential for comprehension of the mechanisms by which these proteins act. I have studied AGO2 interactions …
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Statistical analysis of protein interaction network topology
Complex networks arise in diverse areas of natural and social sciences and network topology is a key determinant of such systems. In this work we investigate the protein-protein interaction network of the KSHV herpesvirus, which is the first viral system available, and compare it to a prototypical …
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Towards a comprehensive human protein-protein interaction network
Obtaining a reliable interaction data set describing the human interactome is a milestone yet to be reached. The past few years has seen tremendous progress in elucidating the yeast interactome. Experimental approaches for obtaining large-scale protein interaction data coupled with powerful …
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The Arf GTPase exchange factor Sec7p interaction network:
… main crossroad of the intracellular trafficking network in all eukaryotic cells and plays a crucial role in the distribution of cellular material. To ensure the proper sorting and delivery of cargo proteins to their destination while maintaining Golgi homeostasis the coordination of all transport …
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Artificial Language Evolution on a Dynamical Interaction Network
… dissertation studies the impact of a dynamical interaction network on the distributed learning of a common language. We derive a new algorithm for generating realistic complex networks, called Noisy Preferential Attachment (NPA). This is a modification of preferential attachment that unifies it …
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A genetic interaction network of constitutive heterochromatin in Caenorhabditis elegans
… not well understood. In this work, I defined a network of functional components of constitutive heterochromatin in *Caenorhabditis elegans* through conducting a set of genetic interaction screens. I began by designing a high throughput screening approach using RNAi to find genetic enhancers and …
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Predicting drug - target interaction network using deep learning models for drug repurposing through genetic information
… drug repurposing through predicting drug-target interaction networks using biological and chemical properties of drugs and targets. However, due to the high-dimensional nature of the data sets extracted from drugs and targets, which have hundreds of thousands of features and relatively small …
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The Chlamydia Trachomatis Protein Interaction Network: Insights into the Unique Composition of the Type Three Secretion System
… two-hybrid analysis. We discovered several novel interactions between and determined that the C. trachomatis T3S apparatus displayed a similar architecture to that of other T3S systems. Furthermore with these approaches we identified networks of proteins that interacted with the secretion …
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Using Persistent Homology for Topological Analysis of Protein Interaction Network of Candida Antarctica Lipase B Molecular Dynamic Simulation Model
… activity. Next, we build the protein interaction network of amino acids for CalB to study pairwise interactions between amino acids (nodes) and probe the protein in terms of statistical features of links’ distribution. Finally, we employ an algebraic topology-based method to study the …
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Development of a computer-aided design supporting system for transformative product design
… <p>To expedite the TPD paradigm, <em>Interaction Network</em> is introduced to represent a product design by following a representative product design representation method in the teleological perspective. However, generating an interaction network of a product is very cumbersome and …
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Identifying Evolutionarily Conserved Protein Interaction Networks
Our goal is to investigate protein networks conserved between different organisms. Given the protein interaction networks for two species and a list of homologous pairs of protein in the two species, we propose a model for measuring whether two subnetworks, one in each protein interaction network, …
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The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules
… within cells. Biomolecules condense through interactions. When the sum and duration of collective interactions reach the percolation threshold, a system-spanning inter- action network is achieved, resulting in phase separation to create a low-viscosity liquid, i.e., biomolecular condensate. …
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Genome data analysis, protein function and structure prediction by machine learning techniques
… described. First of all, we generate gene-gene interaction network from human genome conformation data by Hi-C technique, and the relationship of gene function and gene-gene interaction has been discovered. Second, we introduce a novel framework SMISS, which uses new source of information from …
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Investigation of HIV-TB co-infection through analysis of the potential impact of host genetic variation on host-pathogen protein interactions
… genome. We generated a host-pathogen functional interaction network made up of inter- and intraspecies protein interactions, gene expression during co-infection, drug-target interactions, and human genetic variation. Differential expression and network centrality properties were used to …
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Systems Biology in an Imperfect World: Modeling Biological Systems with Incomplete Information
… biology is to understand the complex underlying network of biochemical interactions which allow an organism to respond to environmental stimuli. Models of these biological interactions serve as a tool to both codify current understanding of these interactions as well as a starting point for …
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Insights into the Substrate Binding Specificity of Quorum-Quenching Acylase PVDQ
… molecular dynamics (MD) simulations, residue interaction network analysis, and binding free energy calculations. The main findings are: firstly, results from pKa predictions support the observation that the pKa of the N-terminus of Serβ1 was depressed due to the surrounding residues. Multiple …
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Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue
… to unwanted side effects. Protein-protein interactions regulate Nav channel function and represent a promising target for developing new drugs. Understanding the protein-protein interaction network of Nav channels will provide new therapeutic targets to tackle the lack of Nav isoform …
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Insights into microbial community structure from pairwise interaction networks
… approach to investigate the role of interspecies interactions in determining the structure of multispecies communities. First, we investigate the network of pairwise competitive interactions in a model community consisting of 20 strains of naturally co-occurring soil bacteria. The resulting …
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